Ecological diversity indices as measurements of tumor heterogeneity correlates with clinical outcomes in late stage small cell lung cancer (SCLC) von Yaung, S., Xi, L., Woestmann, C., McNamara, S., Hinzmann, B., Froehler, S., Tikoo, N., Ju, C., Balasubramanyam, A., Adams, H.-P., Thomas, M., Lasitschka, F., Meister, M., Schneider, M., Herth, F.J.F., Muley, T., Wehnl, B., Palma, J., Ma, X.M.

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FRI0269 Diffuse Cutaneous Systemic Sclerosis (dcSSc) Referral and Diagnosis: Results of A Survey of Healthcare Providers von Khanna, D., Allanore, Y., Denton, C., Matucci-Cerinic, M., Pope, J., Hinzmann, B., Briody, S., de Oliveira Pena, J., Distler, O.

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FRI0270 Patient Perception of Disease Burden in Diffuse Cutaneous Systemic Sclerosis (DcSSc) von Khanna, D., Allanore, Y., Denton, C., Matucci-Cerinic, M., Pope, J., Hinzmann, B., Briody, S., de Oliveira Pena, J., Distler, O.

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Exhaustive mining of EST libraries for genes differentially expressed in normal and tumour tissues von Schmitt, Armin O., Specht, Thomas, Beckmann, Georg, Dahl, Edgar, Pilarsky, Christian P., Hinzmann, Bernd, Rosenthal, André

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1800P Concordance between treatment-naive tissue and circulating tumour DNA (ctDNA) in late stage non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) von Woestmann, C., Jiang, J., Palma, J.F., Ju, C., Heussel, C.P., Kriegsmann, M., Yaung, S., Thomas, M., Meister, M., Schneider, M., Herth, F., Muley, T., Wehnl, B., Hinzmann, B.

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1356P Disease monitoring and TKI resistance mutations of EGFR mutation-positive NSCLC patients via circulating tumour DNA von Ju, C., Jiang, J., Woestmann, C., Hinzmann, B., Yaung, S., Thomas, M., Heussel, C.P., Kriegsmann, M., Meister, M., Schneider, M., Herth, F., Muley, T., Wehnl, B., Palma, J.F.

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Mutational profiling of tumour tissue and sequential plasma illustrates emergent clones during treatment in late stage small cell lung cancer (SCLC) von Yaung, S., Woestmann, C., Xi, L., Ju, C., Hinzmann, B., Thomas, M., Lasitschka, F., Meister, M., Schneider, M., Herth, F.J.F., Muley, T., Wehnl, B., Palma, J., Ma, X.M.

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1744P - Mutational profiling of tumour tissue and sequential plasma illustrates emergent clones during treatment in late stage small cell lung cancer (SCLC) von Yaung, S., Woestmann, C., Xi, L., Ju, C., Hinzmann, B., Thomas, M., Lasitschka, F., Meister, M., Schneider, M., Herth, F.J.F., Muley, T., Wehnl, B., Palma, J., Ma, X.M.

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P2.03-25 Assessing the Impact of Clonal Hematopoiesis in Disease Monitoring Using Targeted Cell-Free DNA (cfDNA) Sequencing Technology von Yaung, S., Xi, L., Woestmann, C., Ju, C., Klass, D., Casey, F., Hinzmann, B., Heussel, C., Thomas, M., Herth, F., Muley, T., Wehnl, B., Palma, J., Ma, X.

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1744PMutational profiling of tumour tissue and sequential plasma illustrates emergent clones during treatment in late stage small cell lung cancer (SCLC) von Yaung, S, Woestmann, C, Xi, L, Ju, C, Hinzmann, B, Thomas, M, Lasitschka, F, Meister, M, Schneider, M, Herth, F J F, Muley, T, Wehnl, B, Palma, J, Ma, X M

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P1.01-34 Early Assessment of Therapy Response in Non-Small Cell Lung Cancer (NSCLC) via Longitudinal ctDNA Analysis von Yaung, S., Ma, X., Ju, C., Woestmann, C., Xi, L., Hinzmann, B., Thomas, M., Heussel, C., Lasitschka, F., Meister, M., Schneider, M., Herth, F., Muley, T., Wehnl, B., Palma, J.

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Expression profiling of microdissected matched prostate cancer samples reveals CD166/MEMD and CD24 as new prognostic markers for patient survival von Kristiansen, Glen, Pilarsky, Christian, Wissmann, Christoph, Kaiser, Simone, Bruemmendorf, Thomas, Roepcke, Stefan, Dahl, Edgar, Hinzmann, Bernd, Specht, Thomas, Pervan, Janja, Stephan, Carsten, Loening, Stefan, Dietel, Manfred, Rosenthal, André

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624 Establishment of a large panel of “early” colon carcinoma xenografts as a preclinical tool for identification of predictive biomarkers von Becker, M, Hinzmann, B, Klaman, I, Adams, H.P, Rosenthal, A, Hoffmann, J, Fichtner, I

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P1.15-011 Longitudinal Mutation Monitoring in Plasma Without Matching Tumor Tissue by Deep Sequencing in Small Cell Lung Cancer (SCLC) von Rosenthal, A., Lange, M., Beckert, S., Hinzmann, B., Woestmann, C., Wehnl, B., Schneider, M., Meister, M., Thomas, M., Muley, T., Warth, A., Froehler, S., Palma, J., Herth, F.J.

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Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire von Staub, Eike, Fiziev, Petko, Rosenthal, André, Hinzmann, Bernd

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170PEcological diversity indices as measurements of tumor heterogeneity correlates with clinical outcomes in late stage small cell lung cancer (SCLC) von Yaung, S, Xi, L, Woestmann, C, McNamara, S, Hinzmann, B, Froehler, S, Tikoo, N, Ju, C, Balasubramanyam, A, Adams, H-P, Thomas, M, Lasitschka, F, Meister, M, Schneider, M, Herth, F J F, Muley, T, Wehnl, B, Palma, J, Ma, X M

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SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer von ZELLER, Constanze, HINZMANN, Bernd, SEITZ, Susanne, PROKOPH, Helmuth, BURKHARD-GOETTGES, Elke, FISCHER, Jörg, JANDRIG, Burkhard, SCHWARZ, Lope-Estevez, ROSENTHAL, André, SCHERNECK, Siegfried

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Independent validation of a prognostic classifier (Predictor-C) in a set of 292 patients with colorectal cancer of UICC stage II von Adams, H., Mayr, T., Hinzmann, B., Rosenthal, A.

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ST18 is a breast cancer tumor suppressor gene at human chromosome 8q11.2 von JANDRIG, Burkhard, SEITZ, Susanne, SCHERNECK, Siegfried, ROSENTHAL, André, HINZMANN, Bernd, ARNOLD, Wolfgang, MICHEEL, Burkhard, KOELBLE, Konrad, SIEBERT, Reiner, SCHWARTZ, Arnfried, RUECKER, Karin, SCHLAG, Peter M

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Comparative genome sequence analysis of the Bpa/Str region in mouse and Man von Mallon, A M, Platzer, M, Bate, R, Gloeckner, G, Botcherby, M R, Nordsiek, G, Strivens, M A, Kioschis, P, Dangel, A, Cunningham, D, Straw, R N, Weston, P, Gilbert, M, Fernando, S, Goodall, K, Hunter, G, Greystrong, J S, Clarke, D, Kimberley, C, Goerdes, M, Blechschmidt, K, Rump, A, Hinzmann, B, Mundy, C R, Miller, W, Poustka, A, Herman, G E, Rhodes, M, Denny, P, Rosenthal, A, Brown, S D

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