Cognitive Dysfunctions in Intellectual Disabilities: The Contributions of the Ras-MAPK and PI3K-AKT-mTOR Pathways von Borrie, Sarah C, Brems, Hilde, Legius, Eric, Bagni, Claudia

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Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1 von Brems, Hilde, MSc, Beert, Eline, MSc, de Ravel, Thomy, MD, Legius, Eric, Dr, Prof

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Comprehensive targeted next‐generation sequencing approach in the molecular diagnosis of gastrointestinal stromal tumor von Vanden Bempt, Isabelle, Vander Borght, Sara, Sciot, Raf, Spans, Lien, Claerhout, Sofie, Brems, Hilde, Lehnert, Stefan, Dehaspe, Luc, Fransis, Sabine, Neuville, Bart, Topal, Baki, Schöffski, Patrick, Legius, Eric, Debiec‐Rychter, Maria

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The characteristics of 76 atypical neurofibromas as precursors to neurofibromatosis 1 associated malignant peripheral nerve sheath tumors von Higham, Christine S, Dombi, Eva, Rogiers, Aljosja, Bhaumik, Sucharita, Pans, Steven, Connor, Steve E J, Miettinen, Markku, Sciot, Raf, Tirabosco, Roberto, Brems, Hilde, Baldwin, Andrea, Legius, Eric, Widemann, Brigitte C, Ferner, Rosalie E

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The NF1 Tumor Suppressor Critically Regulates TSC2 and mTOR von Johannessen, Cory M., Reczek, Elizabeth E., James, Marianne F., Brems, Hilde, Legius, Eric, Cichowski, Karen, Cantley, Lewis C.

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Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors von Beert, Eline, Brems, Hilde, Daniëls, Bruno, De Wever, Ivo, Van Calenbergh, Frank, Schoenaers, Joseph, Debiec-Rychter, Maria, Gevaert, Olivier, De Raedt, Thomas, Van Den Bruel, Annick, de Ravel, Thomy, Cichowski, Karen, Kluwe, Lan, Mautner, Victor, Sciot, Raf, Legius, Eric

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Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype von Somers, Riet, De Schepper, Sofie, Denayer, Ellen, Cools, Jan, Legius, Eric, Thomas, Gilles, Brems, Hilde, Sahbatou, Mourad, Taniguchi, Koji, Kato, Reiko, Messiaen, Ludwine, Fryns, Jean-Pierre, Yoshimura, Akihiko, Marynen, Peter, Chmara, Magdalena

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Interaction between a Domain of the Negative Regulator of the Ras-ERK Pathway, SPRED1 Protein, and the GTPase-activating Protein-related Domain of Neurofibromin Is Implicated in Le... von Hirata, Yasuko, Brems, Hilde, Suzuki, Mayu, Kanamori, Mitsuhiro, Okada, Masahiro, Morita, Rimpei, Llano-Rivas, Isabel, Ose, Toyoyuki, Messiaen, Ludwine, Legius, Eric, Yoshimura, Akihiko

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Identification of Codon 146 KRAS Variants in Isolated Epidermal Nevus and Multiple Lesions in Oculoectodermal Syndrome: Confirmation of the Phenotypic Continuum of Mosaic RASopathi... von Beyens, Aude, Dequeker, Laure, Brems, Hilde, Janssens, Sandra, Syryn, Hannes, D'Hooghe, Anne, De Paepe, Pascale, Vanwalleghem, Lieve, Stockman, Annelies, Vankwikelberge, Elena, De Schepper, Sofie, Goeteyn, Marleen, Delbeke, Patricia, Callewaert, Bert

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Prevalence of neurofibromatosis type 1 in congenital pseudarthrosis of the tibia von Kjell, Van Royen, Hilde, Brems, Eric, Legius, Johan, Lammens, Armand, Laumen

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Examination of the genetic factors underlying the cognitive variability associated with neurofibromatosis type 1 von Ottenhoff, Myrthe J., Rietman, André B., Mous, Sabine E., Plasschaert, Ellen, Gawehns, Daniela, Brems, Hilde, Oostenbrink, Rianne, van Minkelen, Rick, Nellist, Mark, Schorry, Elizabeth, Legius, Eric, Moll, Henriette A., Elgersma, Ype

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Legius syndrome, an Update. Molecular pathology of mutations in SPRED1 von Brems, Hilde, Legius, Eric

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Molecular Dissection of Isolated Disease Features in Mosaic Neurofibromatosis Type 1 von Maertens, Ophélia, De Schepper, Sofie, Vandesompele, Jo, Brems, Hilde, Heyns, Ine, Janssens, Sandra, Speleman, Frank, Legius, Eric, Messiaen, Ludwine

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MEK inhibition ameliorates social behavior phenotypes in a Spred1 knockout mouse model for RASopathy disorders von Borrie, Sarah C, Plasschaert, Ellen, Callaerts-Vegh, Zsuzsanna, Yoshimura, Akihiko, D'Hooge, Rudi, Elgersma, Ype, Kushner, Steven A, Legius, Eric, Brems, Hilde

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Glomus Tumors in Neurofibromatosis Type 1: Genetic, Functional, and Clinical Evidence of a Novel Association von BREMS, Hilde, PARK, Caroline, SLOAN, Jennifer L, YAO, Lawrence, LEE, Chyi-Chia Richard, SCIOT, Raf, DE SMET, Luc, LEGIUS, Eric, STEWART, Douglas R, MAERTENS, Ophélia, PEMOV, Alexander, MESSIA, Ludwine, UPADHYAYA, Meena, CLAES, Kathleen, BEERT, Eline, PEETERS, Kristel, MAUTNER, Victor

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Multitumor Case Series of Germline BRCA1 , BRCA2 and CHEK2 -Mutated Patients Responding Favorably on Immune Checkpoint Inhibitors von Kinget, Lisa, Bechter, Oliver, Punie, Kevin, Debruyne, Philip R, Brems, Hilde, Clement, Paul, Roussel, Eduard, Van Herck, Yannick, Albersen, Maarten, Baldewijns, Marcella, Schöffski, Patrick, Beuselinck, Benoit

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Genetic basis of neurofibromatosis type 1 and related conditions, including mosaicism von Legius, Eric, Brems, Hilde

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Constitutional mismatch repair deficiency mimicking Lynch syndrome is associated with hypomorphic mismatch repair gene variants von Gallon, Richard, Brekelmans, Carlijn, Martin, Marie, Bours, Vincent, Schamschula, Esther, Amberger, Albert, Muleris, Martine, Colas, Chrystelle, Dekervel, Jeroen, De Hertogh, Gert, Coupier, Jérôme, Colleye, Orphal, Sepulchre, Edith, Burn, John, Brems, Hilde, Legius, Eric, Wimmer, Katharina

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Pigment epithelium derived factor drives melanocyte proliferation and migration in neurofibromatosis café au lait macules von Lovatt, Charlotte, Williams, Megan, Gibbs, Alex, Mukhtar, Abdullahi, Morgan, Huw J., Lanfredini, Simone, Olivero, Carlotta, Spurlock, Gill, Davies, Sally, Philpott, Charlotte, Tovell, Hannah, Turnpenny, Peter, Baban, Dilair, Knight, Sam, Brems, Hilde, Sampson, Julian R., Legius, Eric, Upadhyaya, Meena, Patel, Girish K.

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Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/β-catenin pathway in a Drosophila model for intellectual disability von Vandewalle, Joke, Langen, Marion, Zschätzsch, Marlen, Zschaetzsch, Marlen, Nijhof, Bonnie, Kramer, Jamie M, Brems, Hilde, Bauters, Marijke, Lauwers, Elsa, Srahna, Mohammed, Marynen, Peter, Verstreken, Patrik, Schenck, Annette, Hassan, Bassem A, Froyen, Guy

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