DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery von Ye, Chaoyang, Ho, Daniel J., Neri, Marilisa, Yang, Chian, Kulkarni, Tripti, Randhawa, Ranjit, Henault, Martin, Mostacci, Nadezda, Farmer, Pierre, Renner, Steffen, Ihry, Robert, Mansur, Leandra, Keller, Caroline Gubser, McAllister, Gregory, Hild, Marc, Jenkins, Jeremy, Kaykas, Ajamete

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An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion von Keller, Caroline Gubser, Shin, Youngah, Monteys, Alex Mas, Renaud, Nicole, Beibel, Martin, Teider, Natalia, Peters, Thomas, Faller, Thomas, St-Cyr, Sophie, Knehr, Judith, Roma, Guglielmo, Reyes, Alejandro, Hild, Marc, Lukashev, Dmitriy, Theil, Diethilde, Dales, Natalie, Cha, Jang-Ho, Borowsky, Beth, Dolmetsch, Ricardo, Davidson, Beverly L., Sivasankaran, Rajeev

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Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy von Nicklin, Paul, Bergman, Philip, Zhang, Bailin, Triantafellow, Ellen, Wang, Henry, Nyfeler, Beat, Yang, Haidi, Hild, Marc, Kung, Charles, Wilson, Christopher, Myer, Vic E., MacKeigan, Jeffrey P., Porter, Jeffrey A., Wang, Y. Karen, Cantley, Lewis C., Finan, Peter M., Murphy, Leon O.

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Notch2 Is Required for Inflammatory Cytokine-Driven Goblet Cell Metaplasia in the Lung von Danahay, Henry, Pessotti, Angelica D., Coote, Julie, Montgomery, Brooke E., Xia, Donghui, Wilson, Aaron, Yang, Haidi, Wang, Zhao, Bevan, Luke, Thomas, Chris, Petit, Stephanie, London, Anne, LeMotte, Peter, Doelemeyer, Arno, Vélez-Reyes, Germán L., Bernasconi, Paula, Fryer, Christy J., Edwards, Matt, Capodieci, Paola, Chen, Amy, Hild, Marc, Jaffe, Aron B.

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Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length von Liu, Shixuan, Ginzberg, Miriam Bracha, Patel, Nish, Hild, Marc, Leung, Bosco, Li, Zhengda, Chen, Yen-Chi, Chang, Nancy, Wang, Yuan, Tan, Ceryl, Diena, Shulamit, Trimble, William, Wasserman, Larry, Jenkins, Jeremy L, Kirschner, Marc W, Kafri, Ran

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R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5 von Ruffner, Heinz, Sprunger, Joëlle, Charlat, Olga, Leighton-Davies, Juliet, Grosshans, Bianka, Salathe, Adrian, Zietzling, Svenja, Beck, Valérie, Therier, Maxime, Isken, Andrea, Xie, Yang, Zhang, Yue, Hao, Huaixiang, Shi, Xiaoying, Liu, Dong, Song, Qinhui, Clay, Ieuan, Hintzen, Gabriele, Tchorz, Jan, Bouchez, Laure C, Michaud, Gregory, Finan, Peter, Myer, Vic E, Bouwmeester, Tewis, Porter, Jeff, Hild, Marc, Bassilana, Fred, Parker, Christian N, Cong, Feng

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Engineering digitizer circuits for chemical and genetic screens in human cells von Wong, Nicole M., Frias, Elizabeth, Sigoillot, Frederic D., Letendre, Justin H., Hild, Marc, Wong, Wilson W.

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Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila von Bell, O, Wirbelauer, C, Hild, M, Scharf, A.N.D, Schwaiger, M, MacAlpine, D.M, Zilbermann, F, Leeuwen, F. van, Bell, S.P, Imhof, A

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Indolyl-Pyridinyl-Propenone-Induced Methuosis through the Inhibition of PIKFYVE von Cho, Hyelim, Geno, Erin, Patoor, Maude, Reid, Adam, McDonald, Rick, Hild, Marc, Jenkins, Jeremy L

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Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins von Beisel, Christian, Buness, Andreas, Roustan-Espinosa, Ian M, Koch, Britta, Schmitt, Sabine, Haas, Stefan A, Hild, Marc, Katsuyama, Tomonori, Paro, Renato

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Essential role of Bmp7 (snailhouse) and its prodomain in dorsoventral patterning of the zebrafish embryo von Dick, A, Hild, M, Bauer, H, Imai, Y, Maifeld, H, Schier, A F, Talbot, W S, Bouwmeester, T, Hammerschmidt, M

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The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo von Hild, M, Dick, A, Rauch, G J, Meier, A, Bouwmeester, T, Haffter, P, Hammerschmidt, M

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Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide von Fischer, Eric S., Böhm, Kerstin, Lydeard, John R., Yang, Haidi, Stadler, Michael B., Cavadini, Simone, Nagel, Jane, Serluca, Fabrizio, Acker, Vincent, Lingaraju, Gondichatnahalli M., Tichkule, Ritesh B., Schebesta, Michael, Forrester, William C., Schirle, Markus, Hassiepen, Ulrich, Ottl, Johannes, Hild, Marc, Beckwith, Rohan E. J., Harper, J. Wade, Jenkins, Jeremy L., Thomä, Nicolas H.

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Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron‑2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA) von Cheung, Atwood K, Hurley, Brian, Kerrigan, Ryan, Shu, Lei, Chin, Donovan N, Shen, Yiping, O’Brien, Gary, Sung, Moo Je, Hou, Ying, Axford, Jake, Cody, Emma, Sun, Robert, Fazal, Aleem, Tomlinson, Ronald C, Jain, Monish, Deng, Lin, Hoffmaster, Keith, Song, Cheng, Van Hoosear, Mailin, Shin, Youngah, Servais, Rebecca, Towler, Christopher, Hild, Marc, Curtis, Daniel, Dietrich, William F, Hamann, Lawrence G, Briner, Karin, Chen, Karen S, Kobayashi, Dione, Sivasankaran, Rajeev, Dales, Natalie A

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling von Huang, Shih-Min A., Mishina, Yuji M., Liu, Shanming, Cheung, Atwood, Stegmeier, Frank, Michaud, Gregory A., Charlat, Olga, Wiellette, Elizabeth, Zhang, Yue, Wiessner, Stephanie, Hild, Marc, Shi, Xiaoying, Wilson, Christopher J., Mickanin, Craig, Myer, Vic, Fazal, Aleem, Tomlinson, Ronald, Serluca, Fabrizio, Shao, Wenlin, Cheng, Hong, Shultz, Michael, Rau, Christina, Schirle, Markus, Schlegl, Judith, Ghidelli, Sonja, Fawell, Stephen, Lu, Chris, Curtis, Daniel, Kirschner, Marc W., Lengauer, Christoph, Finan, Peter M., Tallarico, John A., Bouwmeester, Tewis, Porter, Jeffery A., Bauer, Andreas, Cong, Feng

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SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice von Palacino, James, Swalley, Susanne E, Song, Cheng, Cheung, Atwood K, Shu, Lei, Zhang, Xiaolu, Van Hoosear, Mailin, Shin, Youngah, Chin, Donovan N, Keller, Caroline Gubser, Beibel, Martin, Renaud, Nicole A, Smith, Thomas M, Salcius, Michael, Shi, Xiaoying, Hild, Marc, Servais, Rebecca, Jain, Monish, Deng, Lin, Bullock, Caroline, McLellan, Michael, Schuierer, Sven, Murphy, Leo, Blommers, Marcel J J, Blaustein, Cecile, Berenshteyn, Frada, Lacoste, Arnaud, Thomas, Jason R, Roma, Guglielmo, Michaud, Gregory A, Tseng, Brian S, Porter, Jeffery A, Myer, Vic E, Tallarico, John A, Hamann, Lawrence G, Curtis, Daniel, Fishman, Mark C, Dietrich, William F, Dales, Natalie A, Sivasankaran, Rajeev

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RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling von Zhang, Yue, Liu, Shanming, Mickanin, Craig, Feng, Yan, Charlat, Olga, Michaud, Gregory A., Schirle, Markus, Shi, Xiaoying, Hild, Marc, Bauer, Andreas, Myer, Vic E., Finan, Peter M., Porter, Jeffery A., Huang, Shih-Min A., Cong, Feng

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Identification of NUB1 as a suppressor of mutant Huntingtin toxicity via enhanced protein clearance von Lu, Boxun, Al-Ramahi, Ismael, Valencia, Antonio, Wang, Qiong, Berenshteyn, Frada, Yang, Haidi, Gallego-Flores, Tatiana, Ichcho, Salah, Lacoste, Arnaud, Hild, Marc, DiFiglia, Marian, Botas, Juan, Palacino, James

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Follistatin and Noggin Are Excluded from the Zebrafish Organizer von Bauer, Hermann, Meier, Andrea, Hild, Marc, Stachel, Scott, Economides, Aris, Hazelett, Dennis, Harland, Richard M, Hammerschmidt, Matthias

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HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS von Pandey, Udai Bhan, Nie, Zhiping, Batlevi, Yakup, McCray, Brett A., Ritson, Gillian P., Nedelsky, Natalia B., Schwartz, Stephanie L., DiProspero, Nicholas A., Knight, Melanie A., Schuldiner, Oren, Padmanabhan, Ranjani, Hild, Marc, Berry, Deborah L., Garza, Dan, Hubbert, Charlotte C., Yao, Tso-Pang, Baehrecke, Eric H., Taylor, J. Paul

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