P-195 A cohort of patients (pt) with HER2-positive (HER2+) advanced gastroesophageal cancer (aGEC) treated at our institution after a decade of tailored targeted therapy von Pous Badia, A., Ferrando Díez, A., Hierro Carbó, C., España Fernández, S., Plaja Salarich, A., Notario Rincon, L., Layos Romero, L., Manzano Mozo, J., Font Pous, A., Linares, J., Álvaro Pardo, M., Calsina Berna, A., Sendrós Madroño, M., Hernandez Marfil, A., Riquelme Olivares, M., López Martos, R., Colan Hernández, J., Garsot Savall, E., Caro Gallarín, M., Barluenga Torres, E., Munné, M., Bugés Sánchez, C.

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1188TiP NICE-NEC, a phase II study of platinum-doublet chemotherapy in combination with nivolumab as first-line treatment in subjects with unresectable, locally advanced or metasta... von Martínez, M.C. Riesco, Capdevila, J., Alonso, V., Teule, A., Grande, E., Jimenez-Fonseca, P., Benavent, M., Gordoa, T. Alonso, Custodio, A., Carbó, C. Hierro, López, C., García, I. Sevilla, García-Carbonero, R.

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P-313 Management of frail patients with metastatic pancreatic ductal adenocarcinoma: A single-institution experience von Salarich, A. Plaja, Díez, A. Ferrando, Badia, A. Pous, Rincon, L. Notario, Fernández, S. España, Martín, F. Pérez, Carbó, C. Hierro, Sánchez, C. Bugés, Mozo, J. Manzano, Romero, L. Layos

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P-317 Survival outcomes among patients with locally advanced esophageal cancer treated within a multidisciplinary gastro-esophageal cancer functional unit von Salarich, A. Plaja, Díez, A. Ferrando, Sánchez, C. Bugés, Carbó, C. Hierro, Gallarín, M. Caro, Martín, M. Viciano, Fernández, S. España, Calduch, O. García, Torres, E. Barluenga, Hernández, J. Colan, Martos, R. López, Gonzalez, M. Sendra, Pardo, M. Álvaro, Ortiz, C. Joaquin, Olivares, M. Riquelme, Marfil, A. Hernandez, Ruiz, N. Calderon, Cuellar, M. López, Osuna, M. José, Romero, L. Layos, Mozo, J. Manzano, Pous, A. Font

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P-318 Survival outcomes among patients with locally advanced gastric cancer treated within a multidisciplinary gastro-esophageal cancer functional unit von Díez, A. Ferrando, Salarich, A. Plaja, Carbó, C. Hierro, Savall, E. Garsot, Gallarín, M. Caro, Font, A. Clavell, Romero, L. Layos, Fernández, S. España, Calduch, O. García, Iniesta, R. Rodríguez, Hernández, J. Colan, Martos, R. López, Berna, A. Calsina, Madroño, M. Sendrós, Gonzalez, M. Sendra, Olivares, M. Riquelme, Marfil, A. Hernandez, Cuellar, M. López, Osuna, M. José, Pous, A. Font, Mozo, J. Manzano, Sánchez, C. Bugés

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469P 16-year outcomes of radically treated localized gastric cancer (GC) patients (pt): Real-world data (RWD) of a Spanish institution von Macias Declara, I., Soriano, S., Ribera Fernandez, P., Querol Ninerola, R., Navarro, S., Rivera Herrero, F., Hierro Carbo, C., Luna, A.L., Perez Romero, N., Sauri Nadal, T., Segui Palmer, M.A., Pericay Pijaume, C.

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465P Timing of first-line palliative systemic therapy in metastatic Esophagogastric cancer (mEGC): A European Delphi study von Kamp, D., May, A.M., Adenis, A., Capela Marques, A., Derks, S., Defelice, F., Fokter Dovnik, N., Carbo, C. Hierro, Ilhan-Mutlu, A., Lordick, F., Obermannova, R., Petrillo, A., Puccini, A., Raimundo, A.C., Roviello, G., Siebenhüner, A.R., Slingerland, M., Smyth, E., van Laarhoven, H.W.M., Haj Mohammad, N.

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Early changes in plasma cell-free DNA (cfDNA) as a predictive biomarker of immune checkpoint inhibitors (ICIs) efficacy von Garcia, I. Matos, Moreno, A., Arenillas, C., Carbo, C. Hierro, Munoz-Cosuelo, E., Martin-Liberal, J., Braña, I., Villar, M. Vieito, Azaro, A., Gadea, O. Saavedra Santa, Gonzalez, I. Gardeazabal, Javier, R., Roger, B., Elez, E., Felip, E., Dienstmann, R., Gros, A., Tabernero, J., Toledo, R.D.A., Garralda, E.

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51P Toxicity profile in early clinical trials with fibroblast growth factor receptor (FGFR) inhibitors (FGFRi): 10-years experience of a drug development unit von Rojas Laimito, K.I., Vieito Villar, M., Fullana Grimalt, B., Berché, R., Hierro Carbo, C., Saavedra Santa Gadea, O., Braña, I., Alonso Casal, G., Galvao de Aguiar, V., Lostes Bardaji, M.J., Oliveira, M., Verdaguer, H., Morales Barrera, R., Garcia Duran, C., Zamora, E., Carles Galceran, J., Macarulla, T., Tabernero, J., Garralda Cabanas, E.

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