Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern von Pfeffer, Inga, Brewitz, Lennart, Krojer, Tobias, Jensen, Sacha A., Kochan, Grazyna T., Kershaw, Nadia J., Hewitson, Kirsty S., McNeill, Luke A., Kramer, Holger, Münzel, Martin, Hopkinson, Richard J., Oppermann, Udo, Handford, Penny A., McDonough, Michael A., Schofield, Christopher J.

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Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay von Ehrismann, Dominic, Flashman, Emily, Genn, David N, Mathioudakis, Nicolas, Hewitson, Kirsty S, Ratcliffe, Peter J, Schofield, Christopher J

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Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases von Chowdhury, Rasheduzzaman, McDonough, Michael A., Mecinović, Jasmin, Loenarz, Christoph, Flashman, Emily, Hewitson, Kirsty S., Domene, Carmen, Schofield, Christopher J.

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Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) von McDonough, Michael A., Li, Vivian, Flashman, Emily, Chowdhury, Rasheduzzaman, Mohr, Christopher, Liénard, Benoît M. R., Zondlo, James, Oldham, Neil J., Clifton, Ian J., Lewis, Jeffrey, McNeill, Luke A., Kurzeja, Robert J. M., Hewitson, Kirsty S., Yang, Evelyn, Jordan, Steven, Syed, Rashid S., Schofield, Christopher J.

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Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor von Coleman, Mathew L., McDonough, Michael A., Hewitson, Kirsty S., Coles, Charlotte, Mecinovicí, Jasmin, Edelmann, Mariola, Cook, Kristina M., Cockman, Matthew E., Lancaster, David E., Kessler, Benedikt M., Oldham, Neil J., Ratcliffe, Peter J., Schofield, Christopher J.

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Structural and Mechanistic Studies on the Inhibition of the Hypoxia-inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates von Hewitson, Kirsty S., Liénard, Benoit M.R., McDonough, Michael A., Clifton, Ian J., Butler, Danica, Soares, Alexie S., Oldham, Neil J., McNeill, Luke A., Schofield, Christopher J.

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Posttranslational Hydroxylation of Ankyrin Repeats in IκB Proteins by the Hypoxia-Inducible Factor (HIF) Asparaginyl Hydroxylase, Factor Inhibiting HIF (FIH) von Cockman, Matthew E., Lancaster, David E., Stolze, Ineke P., Hewitson, Kirsty S., McDonough, Michael A., Coleman, Mathew L., Coles, Charlotte H., Yu, Xiaohong, Hay, Ronald T., Ley, Steven C., Pugh, Christopher W., Oldham, Neil J., Masson, Norma, Schofield, Christopher J., Ratcliffe, Peter J.

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Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family von Hewitson, Kirsty S., McNeill, Luke A., Riordan, Madeline V., Tian, Ya-Min, Bullock, Alex N., Welford, Richard W., Elkins, Jonathan M., Oldham, Neil J., Bhattacharya, Shoumo, Gleadle, Jonathan M., Ratcliffe, Peter J., Pugh, Christopher W., Schofield, Christopher J.

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Kinetic Rationale for Selectivity toward N- and C-terminal Oxygen-dependent Degradation Domain Substrates Mediated by a Loop Region of Hypoxia-Inducible Factor Prolyl Hydroxylases von Flashman, Emily, Bagg, Eleanor A.L., Chowdhury, Rasheduzzaman, Mecinović, Jasmin, Loenarz, Christoph, McDonough, Michael A., Hewitson, Kirsty S., Schofield, Christopher J.

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Selective Inhibition of Factor Inhibiting Hypoxia-Inducible Factor von McDonough, Michael A, McNeill, Luke A, Tilliet, Melanie, Papamicaël, Cyril A, Chen, Qiu-Yun, Banerji, Biswadip, Hewitson, Kirsty S, Schofield, Christopher J

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Hypoxia‐Inducible Factor Prolyl‐Hydroxylase: Purification and Assays of PHD2 von Hewitson, Kirsty S., Schofield, Christopher J., Ratcliffe, Peter J.

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Evidence That Two Enzyme-derived Histidine Ligands Are Sufficient for Iron Binding and Catalysis by Factor Inhibiting HIF (FIH) von Hewitson, Kirsty S., Holmes, Samantha L., Ehrismann, Dominic, Hardy, Adam P., Chowdhury, Rasheduzzaman, Schofield, Christopher J., McDonough, Michael A.

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Determination and comparison of specific activity of the HIF-prolyl hydroxylases von Tuckerman, Jason R., Zhao, Yuguang, Hewitson, Kirsty S., Tian, Ya-Min, Pugh, Christopher W., Ratcliffe, Peter J., Mole, David R.

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Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity von Lancaster, David E, McNeill, Luke A, McDonough, Michael A, Aplin, Robin T, Hewitson, Kirsty S, Pugh, Christopher W, Ratcliffe, Peter J, Schofield, Christopher J

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The Selectivity and Inhibition of AlkB von Welford, Richard W D, Schlemminger, Imre, McNeill, Luke A, Hewitson, Kirsty S, Schofield, Christopher J

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Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate von McNeill, Luke A, Flashman, Emily, Buck, Matthew R G, Hewitson, Kirsty S, Clifton, Ian J, Jeschke, Gunnar, Claridge, Timothy D W, Ehrismann, Dominic, Oldham, Neil J, Schofield, Christopher J

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Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase von Gerken, Thomas, Girard, Christophe A, Tung, Yi-Chun Loraine, Webby, Celia J, Saudek, Vladimir, Hewitson, Kirsty S, Yeo, Giles S.H, McDonough, Michael A, Cunliffe, Sharon, McNeill, Luke A, Galvanovskis, Juris, Rorsman, Patrik, Robins, Peter, Prieur, Xavier, Coll, Anthony P, Ma, Marcella, Jovanovic, Zorica, Farooqi, I. Sadaf, Sedgwick, Barbara, Barroso, Inês, Lindahl, Tomas, Ponting, Chris P, Ashcroft, Frances M, O'Rahilly, Stephen, Schofield, Christopher J

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Molecular Cloning, Characterization, and Inhibition Studies of a β-Carbonic Anhydrase from Malassezia globosa, a Potential Antidandruff Target von Hewitson, Kirsty S, Vullo, Daniela, Scozzafava, Andrea, Mastrolorenzo, Antonio, Supuran, Claudiu T

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Direct Analysis of Enzyme-Catalyzed DNA Demethylation von Karkhanina, Anna A, Mecinović, Jasmin, Musheev, Michael U, Krylova, Svetlana M, Petrov, Alexander P, Hewitson, Kirsty S, Flashman, Emily, Schofield, Christopher J, Krylov, Sergey N

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ORF17 from the Clavulanic Acid Biosynthesis Gene Cluster Catalyzes the ATP-dependent Formation of N-Glycyl-clavaminic Acid von Arulanantham, Haren, Kershaw, Nadia J., Hewitson, Kirsty S., Hughes, Claire E., Thirkettle, Jan E., Schofield, Christopher J.

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