Characterization of the Anti-PD-1 Antibody REGN2810 and Its Antitumor Activity in Human PD-1 Knock-In Mice von Burova, Elena, Hermann, Aynur, Waite, Janelle, Potocky, Terra, Lai, Venus, Hong, Seongwon, Liu, Matt, Allbritton, Omaira, Woodruff, Amy, Wu, Qi, D'Orvilliers, Amanda, Garnova, Elena, Rafique, Ashique, Poueymirou, William, Martin, Joel, Huang, Tammy, Skokos, Dimitris, Kantrowitz, Joel, Popke, Jon, Mohrs, Markus, MacDonald, Douglas, Ioffe, Ella, Olson, William, Lowy, Israel, Murphy, Andrew, Thurston, Gavin

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Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning von Haber, Lauric, Olson, Kara, Kelly, Marcus P., Crawford, Alison, DiLillo, David J., Tavaré, Richard, Ullman, Erica, Mao, Shu, Canova, Lauren, Sineshchekova, Olga, Finney, Jennifer, Pawashe, Arpita, Patel, Supriya, McKay, Ryan, Rizvi, Sahar, Damko, Ermelinda, Chiu, Danica, Vazzana, Kristin, Ram, Priyanka, Mohrs, Katja, D’Orvilliers, Amanda, Xiao, Jenny, Makonnen, Sosina, Hickey, Carlos, Arnold, Cody, Giurleo, Jason, Chen, Ya Ping, Thwaites, Courtney, Dudgeon, Drew, Bray, Kevin, Rafique, Ashique, Huang, Tammy, Delfino, Frank, Hermann, Aynur, Kirshner, Jessica R., Retter, Marc W., Babb, Robert, MacDonald, Douglas, Chen, Gang, Olson, William C., Thurston, Gavin, Davis, Samuel, Lin, John C., Smith, Eric

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Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal von Park, Jason S., Rhau, Benjamin, Hermann, Aynur, McNally, Krista A., Zhou, Carmen, Gong, Delquin, Weiner, Orion D., Conklin, Bruce R., Onuffer, James, Lim, Wendell A.

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Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail von Hansen, Johanna, Baum, Alina, Pascal, Kristen E, Russo, Vincenzo, Giordano, Stephanie, Wloga, Elzbieta, Fulton, Benjamin O, Yan, Ying, Koon, Katrina, Patel, Krunal, Chung, Kyung Min, Hermann, Aynur, Ullman, Erica, Cruz, Jonathan, Rafique, Ashique, Huang, Tammy, Fairhurst, Jeanette, Libertiny, Christen, Malbec, Marine, Lee, Wen-Yi, Welsh, Richard, Farr, Glen, Pennington, Seth, Deshpande, Dipali, Cheng, Jemmie, Watty, Anke, Bouffard, Pascal, Babb, Robert, Levenkova, Natasha, Chen, Calvin, Zhang, Bojie, Romero Hernandez, Annabel, Saotome, Kei, Zhou, Yi, Franklin, Matthew, Sivapalasingam, Sumathi, Lye, David Chien, Weston, Stuart, Logue, James, Haupt, Robert, Frieman, Matthew, Chen, Gang, Olson, William, Murphy, Andrew J, Stahl, Neil, Yancopoulos, George D, Kyratsous, Christos A

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Preclinical Development of the Anti-LAG-3 Antibody REGN3767: Characterization and Activity in Combination with the Anti-PD-1 Antibody Cemiplimab in Human PD-1xLAG-3 -Knockin Mice von Burova, Elena, Hermann, Aynur, Dai, Jie, Ullman, Erica, Halasz, Gabor, Potocky, Terra, Hong, Seongwon, Liu, Matt, Allbritton, Omaira, Woodruff, Amy, Pei, Jerry, Rafique, Ashique, Poueymirou, William, Martin, Joel, MacDonald, Douglas, Olson, William C, Murphy, Andrew, Ioffe, Ella, Thurston, Gavin, Mohrs, Markus

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Interference in a Neutralizing Antibody Assay for Odronextamab, a CD20xCD3 Bispecific mAb, from Prior Rituximab Therapy and Possible Mitigation Strategy von Irvin, Susan C., D’Orvilliers, Amanda, Bloch, Nicolin, Boccio, Kayla, Pennucci, Jason, Brouwer-Visser, Jurriaan, Ullman, Erica, Rajadhyaksha, Manoj, Hassanein, Mohamed, Potocky, Terra, Torri, Albert, Hermann, Aynur, Partridge, Michael A.

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VSIG4 interaction with heparan sulfates inhibits VSIG4–complement binding von Ebstein, Sarah Y, Rafique, Ashique, Zhou, Yi, Krasco, Amanda, Montalvo-Ortiz, Welby, Yu, Lola, Custodio, Luisaidy, Adam, Rene C, Bloch, Nicolin, Lee, Ken, Adewale, Funmilola, Vergata, Dominic, Luz, Antonio, Coquery, Sebastien, Daniel, Benjamin, Ullman, Erica, Franklin, Matthew C, Hermann, Aynur, Huang, Tammy, Olson, William, Davis, Samuel, Murphy, Andrew J, Sleeman, Matthew A, Wei, Joyce, Skokos, Dimitris

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Abstract 526: Alternative format bispecific antibodies targeting multiple oncogenic FGFR3 mutations in bladder cancer through different mechanisms von Yang, Yan, Wibowo, Arif, Avvaru, Suhasini, Jiang, Zaoli, Luz, Antonio, Rafique, Ashique, Sarangapani, Prasad, McKay, Ryan, Amatulli, Michael, Vootlakrishna, Meghana, Edwards, Rachel, Potocky, Terra, Hermann, Aynur, Daly, Christopher, Thurston, Gavin, Lin, John Chia-Yang, Shen, Yang

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Abstract 4555: Selection of CD3 affinity allows generation of T-cell redirecting bispecific antibodies with unique pharmacokinetic and biodistribution properties von Haber, Lauric, Olson, Kara, Babb, Robert, Kelly, Marcus, Crawford, Alison, Retter, Marc, DiLillo, David, Ullman, Erica, Finney, Jennifer, Canova, Lauren, Pawashe, Arpita, Chiu, Danica, Vazzana, Kristin, Ram, Priyanka, Mohrs, Katja, Dorvilliers, Amanda, Xiao, Jenny, Makonnen, Sosina, Hickey, Carlos, Arnold, Cody, Giurleo, Jason, Patel, Supriya, Tavare, Richard, Chen, Ya Ping, Chen, Gang, Olson, William, Thurston, Gavin, Lin, John Chia-Yang, Hermann, Aynur, Kirshner, Jessica, Smith, Eric J.

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Immuno-PET Monitoring of Lymphocytes Using the CD8-Specific Antibody REGN5054 von Tavaré, Richard, Danton, Makenzie, Giurleo, Jason T, Makonnen, Sosina, Hickey, Carlos, Arnold, Tomas C, Kelly, Marcus P, Fredriksson, Fanny, Bruestle, Karina, Hermann, Aynur, Ullman, Erica, Edelmann, Kurt H, Potocky, Terra, Dudgeon, Drew, Bhatt, Nikunj B, Doubrovin, Mikhail, Barry, Thomas, Kyratsous, Christos A, Gurer, Cagan, Tu, Naxin, Gartner, Hans, Murphy, Andrew, Macdonald, Lynn E, Popke, Jon, Mintz, Akiva, Griesemer, Adam, Olson, William C, Thurston, Gavin, Ma, Dangshe, Kirshner, Jessica R

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Abstract IA012: REGN10597: A PD-1-targeted, receptor-masked wild type IL-2 with improved therapeutic window for cancer immunotherapy von Wu, Jiaxi, Bloch, Nicolin, Chang, Aaron, Bhavsar, Ramandeep, Wang, Qingqing, Patel, Supriya, Garg, Vidur, Shakil, Hassan, Amatulli, Michael, Dudgeon, Drew, Yan, Yuetian, Wang, Shunhai, Ramos, Willy, Krueger, Pamela, Vazzana, Kristin, Crawford, Alison, Idun, Jacqueline, Decker, Corinne, DiLillo, David, Chandwani, Samira, Huang, Tammy, Kirshner, Jessica, Guo, Chungguang, Macdonald, Lynn, Ullman, Erica, Hermann, Aynur, Olson, William, Davis, Samuel, Lin, John, Smith, Eric, Zhang, Tong

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A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies von Wu, Jiaxi, Bloch, Nicolin, Chang, Aaron Y., Bhavsar, Ramandeep, Wang, Qingqing, Crawford, Alison, DiLillo, David J., Vazzana, Kristin, Mohrs, Katja, Dudgeon, Drew, Patel, Supriya, Ahmed, Hassan, Garg, Vidur, Amatulli, Michael, Antao, Olivia Q., Yan, Yuetian, Wang, Shunhai, Ramos, Willy, Krueger, Pamela, Adler, Christina, Ni, Min, Wei, Yi, Guo, Chunguang, Macdonald, Lynn, Huang, Tammy, Ullman, Erica, Hermann, Aynur, Yancopoulos, George D., Murphy, Andrew J., Davis, Samuel, Olson, William C., Lin, John C., Smith, Eric, Zhang, Tong

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Abstract 4434: A PD-1-targeted, receptor-masked IL-2 immunocytokine with maintained potential to engage endogenous IL-2Ra drives selective stimulation of PD-1+ T cells and robust a... von Wu, Jiaxi, Bloch, Nicolin, Chang, Aaron, Bhavsar, Ramandeep, Patel, Supriya, Wang, Qingqing, Ahmed, Hassan Shakil, Garg, Vidur, Amatulli, Michael, Yan, Yuetian, Wang, Shunhai, Dudgeon, Drew, Ramos, Willy, Krueger, Pamela, Rafique, Ashique, Huang, Tammy, Ullman, Erica, Hermann, Aynur, Olson, William, Lin, John, Smith, Eric, Zhang, Tong

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Anti-lag3 antibodies and uses thereof von Hermann, Aynur, Thurston, Gavin, Burova, Elena, Ullman, Erica, Ioffe, Ella

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BIOCHEMICAL ASSAYS FOR THERAPEUTIC PROTEINS von HERMANN, Aynur, RAJADHYAKSHA, Manoj, PARTRIDGE, Michael, IRVIN, Susan

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INDUCED NK CELLS RESPONSIVE TO CD3/TAA BISPECIFIC ANTIBODIES von HERMANN, Aynur, ULLMAN, Erica, OLSON, William, BLOCH, Nicolin, YANCOPOULOS, George

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INDUCED NK CELLS RESPONSIVE TO CD3/TAA BISPECIFIC ANTIBODIES von HERMANN, Aynur, ULLMAN, Erica, OLSON, William, BLOCH, Nicolin, YANCOPOULOS, George

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Anti-CTLA-4 antibodies and uses thereof von HERMANN, Aynur, OLSON, William, BUROVA, Elena, THURSTON, Gavin, IOFFE, Ella

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Anti-CTLA-4 antibodies and uses thereof von Olson, William, Hermann, Aynur, Thurston, Gavin, Burova, Elena, Ioffe, Ella

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ANTI-LAG3 ANTIBODIES AND USES THEREOF von HERMANN, Aynur, ULLMAN, Erica, BUROVA, Elena, THURSTON, Gavin, IOFFE, Ella

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