CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population von Mirghani, Rajaa A, Sayi, Jane, Aklillu, Eleni, Allqvist, Annika, Jande, Mary, Wennerholm, Agneta, Eriksen, Jaran, Herben, Virginie M.M, Jones, Barry C, Gustafsson, Lars L, Bertilsson, Leif

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Clinical pharmacokinetics of topotecan von HERBEN, V. M. M, TEN BOKKEL HUININK, W. W, BEIJNEN, J. H

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Oral topotecan: bioavailability and effect of food co-administration von Herben, V M M, Rosing, H, Huinink, W W ten Bokkel, Zomeren, D M van, Batchelor, D, Doyle, E, Beusenberg, F D, Beijnen, J H, Schellens, J H M

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Phase I and Pharmacokinetic Study of Irinotecan Administered as a Low-Dose, Continuous Intravenous Infusion Over 14 Days in Patients With Malignant Solid Tumors von HERBEN, V. M. M, SCHELLENS, J. H. M, SWART, M, GRUIA, G, VERNILLET, L, BEIJNEN, J. H, TEN BOKKEL HUININK, W. W

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Urinary and fecal excretion of topotecan in patients with malignant solid tumours von HERBEN, Virginie M. M, SCHOEMAKER, Nadja E, ROSING, Hilde, VAN ZOMEREN, Desiree M, TEN BOKKEL HUININK, Wim W, DUBBELMAN, Ria, HEARN, Solange, SCHELLENS, Jan H. M, BEIJNEN, Jos H

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Phase I and pharmacokinetic study of the combination of topotecan and ifosfamide administered intravenously every 3 weeks von Kerbusch, T, Groenewegen, G, Mathôt, R A A, Herben, V M M, ten Bokkel Huinink, W W, Swart, M, Ambaum, B, Rosing, H, Jansen, S, Voest, E E, Beijnen, J H, Schellens, J H M

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Phase I and Pharmacologic Study of the Combination of Paclitaxel, Cisplatin, and Topotecan Administered Intravenously Every 21 Days as First-Line Therapy in Patients With Advanced... von HERBEN, V. M. M, NANNAN PANDAY, V. R, TEN BOKKEL HUININK, W. W, RICHEL, D. J, SCHELLENS, J. H. M, VAN DER VANGE, N, ROSING, H, BEUSENBERG, F. D, HEARN, S, DOYLE, E, BEIJNEN, J. H

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Phase I and pharmacological study of sequential intravenous topotecan and oral etoposide von Herben, VMM, ten Bokkel Huinink, WW, Dubbelman, AC, Mandjes, IAM, Groot, Y, van Gortel-van Zomeren, DM, Beijnen, JH

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Isolation and structural confirmation of N-desmethyl topotecan, a metabolite of topotecan von ROSING, H, HERBEN, V. M. M, VAN GORTEL-VAN ZOMEREN, D. M, HOP, E, KETTENES-VAN DEN BOSCH, J. J, TEN BOKKEL HUININK, W. W, BEIJNEN, J. H

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Topoisomerase I levels in white blood cells of patients with ovarian cancer treated with paclitaxel–cisplatin–topotecan in a phase I study von Schoemaker, Nadja E, Herben, Virginie MM, de Jong, Laurina A, van Waardenburg, Robert CAM, Pluim, Dick, ten Bokkel Huinink, Wim W, Beijnen, Jos H, Schellens, Jan HM

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Phase I and Pharmacokinetic Study of a Daily Times 5 Short Intravenous Infusion Schedule of 9-Aminocamptothecin in a Colloidal Dispersion Formulation in Patients With Advanced Soli... von HERBEN, V. M. M, VAN GIJN, R, SCHELLENS, J. H. M, SCHOT, M, LIEVERST, J, HILLEBRAND, M. J. X, SCHOEMAKER, N. E, PORRO, M. G, BEIJNEN, J. H, TEN BOKKEL HUININK, W. W

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Continuous infusion of low-dose topotecan: pharmacokinetics and pharmacodynamics during a phase II study in patients with small cell lung cancer von Herbert, Virginie MM, Bokkel Huinink, Wim W ten, Schot, Margaret E, Hudson, Ian, Beijnen, Jos H

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Distribution of ifosfamide and metabolites between plasma and erythrocytes von Kerbusch, T., Herben, V.M.M., Jeuken, M-J.J., Ouwerkerk, J., Keizer, H.J., Beijnen, J.H.

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High-performance liquid chromatographic analysis of the investigational anticancer drug 9-aminocamptothecin, as the lactone form and as the total of the lactone and the hydroxycarb... von van Gijn, R., Herben, V.M.M., Hillebrand, M.J.X., ten Bokkel Huinink, W.W., Bult, A., Beijnen, J.H.

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Sensitive Determination of the Carboxylate and Lactone Forms of the Novel Antitumor Drug Irinotecan and Its Active Metabolite in Plasma by HPLC von Herben, V. M. M., Mazee, D., van Gortel-van Zomeren, D. M., Zeedijk, S., Rosing, H., Schellens, J. H. M., ten Bokkel Huinink, W. W., Beijnen, J. H.

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Oral Bioavailability of Low Dose (20mg) ‘Home-Made’ Etoposide Capsules von Jonkman-de Vries, J.D., Herben, V.M.M., van Tellingen, O., Dubbelman, A.C., ten Bokkel Huinink, W.W., Rodenhuis, S., Bult, A., Beijnen, J.H.

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