Stromal Senescence By Prolonged CDK4/6 Inhibition Potentiates Tumor Growth von Guan, Xiangnan, LaPak, Kyle M, Hennessey, Rebecca C, Yu, Christina Y, Shakya, Reena, Zhang, Jianying, Burd, Christin E

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Cancer regulatory variation von Hennessey, Rebecca C, Brown, Kevin M

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A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR von Xu, Mai, Mehl, Lindsey, Zhang, Tongwu, Thakur, Rohit, Sowards, Hayley, Myers, Timothy, Jessop, Lea, Chesi, Alessandra, Johnson, Matthew E., Wells, Andrew D., Michael, Helen T., Bunda, Patricia, Jones, Kristine, Higson, Herbert, Hennessey, Rebecca C., Jermusyk, Ashley, Kovacs, Michael A., Landi, Maria Teresa, Iles, Mark M., Goldstein, Alisa M., Choi, Jiyeon, Chanock, Stephen J., Grant, Struan F.A., Chari, Raj, Merlino, Glenn, Law, Matthew H., Brown, Kevin M.

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Cell‐intrinsic melanin fails to protect melanocytes from ultraviolet‐mutagenesis in the absence of epidermal melanin von Weiss, Tirzah J., Crawford, Emma R., Posada, Valentina, Rahman, Hafeez, Liu, Tong, Murphy, Brandon M., Arnold, Tiffany E., Gray, Shannon, Hu, Zhexuan, Hennessey, Rebecca C., Yu, Lianbo, D'Orazio, John A., Burd, Craig J., Zippin, Jonathan H., Grossman, Douglas, Burd, Christin E.

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Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma von Choi, Jiyeon, Zhang, Tongwu, Vu, Andrew, Ablain, Julien, Makowski, Matthew M., Colli, Leandro M., Xu, Mai, Hennessey, Rebecca C., Yin, Jinhu, Rothschild, Harriet, Gräwe, Cathrin, Kovacs, Michael A., Funderburk, Karen M., Brossard, Myriam, Taylor, John, Pasaniuc, Bogdan, Chari, Raj, Chanock, Stephen J., Hoggart, Clive J., Demenais, Florence, Barrett, Jennifer H., Law, Matthew H., Iles, Mark M., Yu, Kai, Vermeulen, Michiel, Zon, Leonard I., Brown, Kevin M.

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The Exportin-1 Inhibitor Selinexor Exerts Superior Antitumor Activity when Combined with T-Cell Checkpoint Inhibitors von Farren, Matthew R, Hennessey, Rebecca C, Shakya, Reena, Elnaggar, Omar, Young, Gregory, Kendra, Kari, Landesman, Yosef, Elloul, Sivan, Crochiere, Marsha, Klebanov, Boris, Kashyap, Trinayan, Burd, Christin E, Lesinski, Gregory B

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Ultraviolet radiation accelerates NRas‐mutant melanomagenesis: A cooperative effect blocked by sunscreen von Hennessey, Rebecca C., Holderbaum, Andrea M., Bonilla, Anamaria, Delaney, Conor, Gillahan, James E., Tober, Kathleen L., Oberyszyn, Tatiana M., Zippin, Jonathan H., Burd, Christin E.

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Abstract 2685: Ultraviolet light cooperates with NrasQ61R mutations to drive malignant melanoma von Hennessey, Rebecca C., Holderbaum, Andrea M., Gillahan, James E., Delaney, Conor, Tang, Xing, Kladney, Raleigh, Burd, Christin E.

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UVB mutagenesis differs in Nras - and Braf -mutant mouse models of melanoma von Bowman, Robert L, Hennessey, Rebecca C, Weiss, Tirzah J, Tallman, David A, Crawford, Emma R, Murphy, Brandon M, Webb, Amy, Zhang, Souhui, La Perle, Krista Md, Burd, Craig J, Levine, Ross L, Shain, A Hunter, Burd, Christin E

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Abstract 2827: PD0332991-induced stromal senescence promotes melanoma growth in vivo von Guan, Xiangnan, Lapak, Kyle, Hennessey, Rebecca, Burd, Christin

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Abstract 900: In vivo modeling of NRAS -mutant melanoma reveals differential preventative efficacy amongst SPF30 sunscreens von Holderbaum, Andrea M., Hennessey, Rebecca C., Gillahan, James E., Bonilla, Anamaria, Delaney, Conor, Kladney, Raleigh D., Tober, Kathleen L., Oberyszyn, Tatiana M., Burd, Christin E.

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Abstract 2319: Selinexor, a selective inhibitor of nuclear export (SINE), enhances the in vivo efficacy of checkpoint blockade with antibodies targeting CTLA4 or PD-1/PD-L1 in mela... von Farren, Matthew R., Shakya, Reena, Hennessey, Rebecca, Mace, Thomas, Yang, Jennifer, Elnaggar, Omar, Young, Gregory, Landesman, Yosef, Carlson, Robert, Elloul, Sivan, Crochiere, Marsha, Burd, Christin, Lesinski, Gregory B.

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Ultraviolet radiation accelerates NR as‐mutant melanomagenesis: A cooperative effect blocked by sunscreen von Hennessey, Rebecca C., Holderbaum, Andrea M., Bonilla, Anamaria, Delaney, Conor, Gillahan, James E., Tober, Kathleen L., Oberyszyn, Tatiana M., Zippin, Jonathan H., Burd, Christin E.

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The exportin-1 inhibitor selinexor exerts superior anti-tumor activity when combined with T cell checkpoint inhibitors von Farren, Matthew R., Hennessey, Rebecca C., Shakya, Reena, Elnaggar, Omar, Young, Gregory, Kendra, Kari, Landesman, Yosef, Elloul, Sivan, Crochiere, Marsha, Klebanov, Boris, Kashyap, Trinayan, Burd, Christin E., Lesinski, Gregory B.

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Abstract 5239: Integrative analysis of 3D chromatin organization at GWAS loci identifies RAPGEF1 as a melanoma susceptibility gene von Thakur, Rohit, Xu, Mai, Thornock, Alexandra, Sowards, Hayley, Long, Epring, Rheling, Thomas, Funderburk, Karen, Yin, Jinhu, Hennessey, Rebecca, Chari, Raj, Zhang, Tongwu, Jessop, Lea, Myers, Timothy, Johnson, Matthew E., Wells, Andrew D., Chesi, Alessandra, Grant, Struan F., Iles, Mark I., Landi, Maria T., Law, Matthew, Consortium, Melanoma Meta-Analysis, Machiela, Mitchell, Choi, Jiyeon, Zon, Leonard I., Brown, Kevin M.

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Selinexor, a selective inhibitor of nuclear export von Crochiere, Marsha, Young, Gregory, Carlson, Robert, Elnaggar, Omar, Yang, Jennifer, Elloul, Sivan, Mace, Thomas, Lesinski, Gregory, Hennessey, Rebecca, Burd, Christin, Landesman, Yosef, Shakya, Reena, Farren, Matthew R

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Selinexor, a selective inhibitor of nuclear export (SINE), shows enhanced activity in combination with PD-1/PD-L1 blockade in syngeneic murine models of colon cancer and melanoma von Farren, Matthew R, Shakya, Reena, Hennessey, Rebecca, Mace, Thomas, Yang, Jennifer, Elnaggar, Omar, Young, Gregory, Landesman, Yosef, Carlson, Robert, Elloul, Sivan, Crochiere, Marsha, Burd, Christin, Lesinski, Gregory

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The Parental Comparison Level Index: A Measure for Assessing Parental Rewards and Costs Relative to Expectations von Waldron-Hennessey, Rebecca, Sabatelli, Ronald M.

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Why Parents Matter: Parental Investment and Child Outcomes von Barber, Nigel, Waldron-Hennessey, Rebecca

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Tu1005 EVOLUTION AT THE US FOOD AND DRUG ADMINISTRATION: SCOPING REVIEW TO ASSESS RISK TOLERANCE OF FDA FOR NEW MEDICAL DEVICES AND TECHNOLOGY IN GASTROENTEROLOGY von Xue, Shan, Hennessey, Megan M., Strigenz, Rebecca Z., Shah, Eric D.

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