Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731 von Huang, Qi, Cai, Dawei, Yan, Ran, Li, Lichun, Zong, Yuhua, Guo, Lida, Mercier, Alexandre, Zhou, Yi, Tang, Ariel, Henne, Kirk, Colonno, Richard

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Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme von Arguello, Annie, Mahon, Cathal S, Calvert, Meredith E K, Chan, Darren, Dugas, Jason C, Pizzo, Michelle E, Thomsen, Elliot R, Chau, Roni, Damo, Lorna A, Duque, Joseph, Fang, Meng, Giese, Tina, Kim, Do Jin, Liang, Nicholas, Nguyen, Hoang N, Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Ullman, Julie C, Wang, Junhua, Dennis, Mark S, Diaz, Dolores, Gunasekaran, Kannan, Henne, Kirk R, Lewcock, Joseph W, Sanchez, Pascal E, Troyer, Matthew D, Harris, Jeffrey M, Scearce-Levie, Kimberly, Shan, Lu, Watts, Ryan J, Thorne, Robert G, Henry, Anastasia G, Kariolis, Mihalis S

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High-Throughput Liquid Chromatography-Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II von Wang, Junhua, Bhalla, Akhil, Ullman, Julie C., Fang, Meng, Ravi, Ritesh, Arguello, Annie, Thomsen, Elliot, Tsogtbaatar, Buyankhishig, Guo, Jing L., Skuja, Lukas L., Dugas, Jason C., Davis, Sonnet S., Poda, Suresh B., Gunasekaran, Kannan, Costanzo, Simona, Sweeney, Zachary K., Henry, Anastasia G., Harris, Jeffrey M., Henne, Kirk R., Astarita, Giuseppe

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Discovery and in Vivo Evaluation of (S)‑N‑(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)‑9H‑purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune D... von Cushing, Timothy D., Hao, Xiaolin, Shin, Youngsook, Andrews, Kristin, Brown, Matthew, Cardozo, Mario, Chen, Yi, Duquette, Jason, Fisher, Ben, Gonzalez-Lopez de Turiso, Felix, He, Xiao, Henne, Kirk R., Hu, Yi-Ling, Hungate, Randall, Johnson, Michael G., Kelly, Ron C., Lucas, Brian, McCarter, John D., McGee, Lawrence R., Medina, Julio C., San Miguel, Tisha, Mohn, Deanna, Pattaropong, Vatee, Pettus, Liping H., Reichelt, Andreas, Rzasa, Robert M., Seganish, Jennifer, Tasker, Andrew S., Wahl, Robert C., Wannberg, Sharon, Whittington, Douglas A., Whoriskey, John, Yu, Gang, Zalameda, Leeanne, Zhang, Dawei, Metz, Daniela P.

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Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to... von Henne, Kirk R, Ason, Brandon, Howard, Monique, Wang, Wei, Sun, Jeonghoon, Higbee, Jared, Tang, Jie, Matsuda, Katherine C, Xu, Ren, Zhou, Lei, Chan, Joyce C Y, King, Chadwick, Piper, Derek E, Ketchem, Randal R, Michaels, Mark Leo, Jackson, Simon M, Retter, Marc W

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Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome von Arguello, Annie, Meisner, Rene, Thomsen, Elliot R., Nguyen, Hoang N., Ravi, Ritesh, Simms, Jeffrey, Lo, Iris, Speckart, Jessica, Holtzman, Julia, Gill, Thomas M., Chan, Darren, Cheng, Yuhsiang, Chiu, Chi-Lu, Dugas, Jason C., Fang, Meng, Lopez, Isabel A., Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Zhu, Yuda, Bhalla, Akhil, Henne, Kirk R., Henry, Anastasia G., Delucchi, Anthony, Costanzo, Simona, Harris, Jeffrey M., Diaz, Dolores, Scearce-Levie, Kimberly, Sanchez, Pascal E.

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Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhib... von Henne, Kirk R, Tran, Thuy B, VandenBrink, Brooke M, Rock, Dan A, Aidasani, Divesh K, Subramanian, Raju, Mason, Andrew K, Stresser, David M, Teffera, Yohannes, Wong, Simon G, Johnson, Michael G, Chen, Xiaoqi, Tonn, George R, Wong, Bradley K

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Bioactivation of 4-Ipomeanol by CYP4B1:  Adduct Characterization and Evidence for an Enedial Intermediate von Baer, Brian R, Rettie, Allan E, Henne, Kirk R

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Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4 von Kalgutkar, Amit S., Henne, Kirk R., Lame, Mary E., Vaz, Alfin D.N., Collin, Claire, Soglia, John R., Zhao, Sabrina X., Hop, Cornelis E.C.A.

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Bioactivation of a Novel 2-Methylindole-Containing Dual Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type-2 Cells/D-Prostanoid Receptor Antagonist Leads to Me... von WONG, Simon G, FAN, Peter W, SUBRAMANIAN, Raju, TONN, George R, HENNE, Kirk R, JOHNSON, Michael G, TADANO LOHR, Michelle, WONG, Bradley K

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Covalent Linkage of Prosthetic Heme to CYP4 Family P450 Enzymes von Henne, Kirk R, Kunze, Kent L, Zheng, Yi-Min, Christmas, Peter, Soberman, Roy J, Rettie, Allan E

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Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome von Arguello, Annie, Meisner, René, Thomsen, Elliot R., Nguyen, Hoang N., Ravi, Ritesh, Simms, Jeffrey, Lo, Iris, Speckart, Jessica, Holtzman, Julia, Gill, Thomas M., Chan, Darren, Cheng, Yuhsiang, Chiu, Chi-Lu, Dugas, Jason C., Fang, Meng, Lopez, Isabel A., Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Zhu, Yuda, Bhalla, Akhil, Henne, Kirk R., Henry, Anastasia G., Delucchi, Anthony, Costanzo, Simona, Harris, Jeffrey M., Diaz, Dolores, Scearce-Levie, Kimberly, Sanchez, Pascal E.

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A comparison of substrate dynamics in human CYP2E1 and CYP2A6 von Harrelson, John P., Henne, Kirk R., Alonso, Darwin O.V., Nelson, Sidney D.

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Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation von Liao, Fan, Li, Aimin, Xiong, Monica, Bien-Ly, Nga, Jiang, Hong, Zhang, Yin, Finn, Mary Beth, Hoyle, Rosa, Keyser, Jennifer, Lefton, Katheryn B, Robinson, Grace O, Serrano, Javier Remolina, Silverman, Adam P, Guo, Jing L, Getz, Jennifer, Henne, Kirk, Leyns, Cheryl Eg, Gallardo, Gilbert, Ulrich, Jason D, Sullivan, Patrick M, Lerner, Eli Paul, Hudry, Eloise, Sweeney, Zachary K, Dennis, Mark S, Hyman, Bradley T, Watts, Ryan J, Holtzman, David M

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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic von Logan, Todd, Simon, Matthew J., Rana, Anil, Cherf, Gerald M., Srivastava, Ankita, Davis, Sonnet S., Low, Ray Lieh Yoon, Chiu, Chi-Lu, Fang, Meng, Huang, Fen, Bhalla, Akhil, Llapashtica, Ceyda, Prorok, Rachel, Pizzo, Michelle E., Calvert, Meredith E.K., Sun, Elizabeth W., Hsiao-Nakamoto, Jennifer, Rajendra, Yashas, Lexa, Katrina W., Srivastava, Devendra B., van Lengerich, Bettina, Wang, Junhua, Robles-Colmenares, Yaneth, Kim, Do Jin, Duque, Joseph, Lenser, Melina, Earr, Timothy K., Nguyen, Hoang, Chau, Roni, Tsogtbaatar, Buyankhishig, Ravi, Ritesh, Skuja, Lukas L., Solanoy, Hilda, Rosen, Howard J., Boeve, Bradley F., Boxer, Adam L., Heuer, Hilary W., Dennis, Mark S., Kariolis, Mihalis S., Monroe, Kathryn M., Przybyla, Laralynne, Sanchez, Pascal E., Meisner, Rene, Diaz, Dolores, Henne, Kirk R., Watts, Ryan J., Henry, Anastasia G., Gunasekaran, Kannan, Astarita, Giuseppe, Suh, Jung H., Lewcock, Joseph W., DeVos, Sarah L., Di Paolo, Gilbert

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Enzymatic Determinants of the Substrate Specificity of CYP2C9:  Role of B‘−C Loop Residues in Providing the π-Stacking Anchor Site for Warfarin Binding von Haining, Robert L, Jones, Jeffrey P, Henne, Kirk R, Fisher, Michael B, Koop, Dennis R, Trager, William F, Rettie, Allan E

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Covalent Heme Binding to CYP4B1 via Glu310 and a Carbocation Porphyrin Intermediate von Zheng, Yi-Min, Baer, Brian R, Kneller, M. Byron, Henne, Kirk R, Kunze, Kent L, Rettie, Allan E

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ETV:SGSH, a brain-penetrant enzyme transport vehicle for SGSH, corrects heparan sulfate accumulation, lysosomal lipid storage and inflammation in MPS IIIA mouse brain von Masoud, Shababa T., Jafarnejad, Mohammad, Nguyen, Hoang, Tsogtbaatar, Buyankhishig, Rajendra, Yashas, Seay, Alexander, Thomsen, Elliot R., Yamanokuchi, Kensuke, Arguello, Annie, Fang, Meng, Mahon, Cathal S., Sanchez, Pascal, Diaz, Dolo, Bakardjiev, Anna, Henne, Kirk

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ETV:SGSH, a brain-penetrant enzyme transport vehicle for SGSH, improves lysosomal and microglial morphology, degeneration and cognitive behavior in MPS IIIA mice von Masoud, Shababa T., Nguyen, Hoang, Discenza, Claire, Joy, David, Simms, Jeffrey, Lo, Iris, Chun, You Young, Holtzman, Julia, Tsogtbaatar, Khishig, Leung, Amy Wing-Sze, Becerra, Isabel, Thomsen, Elliot, Gill, Audrey, Rajendra, Yashas, Seay, Alexander, Jafarnejad, Mohammad, Bakardjiev, Anna, Calvert, Meredith E.K., Mahon, Cathal S., Thorne, Robert, Chessler, Steven, Henne, Kirk, Sanchez, Pascal, Arguello, Annie

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proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates von Chan, Joyce C.Y, Piper, Derek E, Cao, Qiong, Liu, Dongming, King, Chadwick, Wang, Wei, Tang, Jie, Liu, Qiang, Higbee, Jared, Xia, Zhen, Di, Yongmei, Shetterly, Susan, Arimura, Ziva, Salomonis, Heather, Romanow, William G, Thibault, Stephen T, Zhang, Richard, Cao, Ping, Yang, Xiao-Ping, Yu, Timothy, Lu, Mei, Retter, Marc W, Kwon, Gayle, Henne, Kirk, Pan, Oscar, Tsai, Mei-Mei, Fuchslocher, Bryna, Yang, Evelyn, Zhou, Lei, Lee, Ki Jeong, Daris, Mark, Sheng, Jackie, Wang, Yan, Shen, Wenyan D, Yeh, Wen-Chen, Emery, Maurice, Walker, Nigel P.C, Shan, Bei, Schwarz, Margrit, Jackson, Simon M

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