A Metabolic Vulnerability of Vision von Tyynismaa, Henna

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Metabolic determination of cell fate through selective inheritance of mitochondria von Döhla, Julia, Kuuluvainen, Emilia, Gebert, Nadja, Amaral, Ana, Englund, Johanna I., Gopalakrishnan, Swetha, Konovalova, Svetlana, Nieminen, Anni I., Salminen, Ella S., Torregrosa Muñumer, Rubén, Ahlqvist, Kati, Yang, Yang, Bui, Hien, Otonkoski, Timo, Käkelä, Reijo, Hietakangas, Ville, Tyynismaa, Henna, Ori, Alessandro, Katajisto, Pekka

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Parents may prefer prognostic uncertainty about their child's genetic neurodevelopmental condition von Tyynismaa, Henna

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Overexpression of TFAM or twinkle increases mtDNA copy number and facilitates cardioprotection associated with limited mitochondrial oxidative stress von Ikeda, Masataka, Ide, Tomomi, Fujino, Takeo, Arai, Shinobu, Saku, Keita, Kakino, Takamori, Tyynismaa, Henna, Yamasaki, Toshihide, Yamada, Ken-Ichi, Kang, Dongchon, Suomalainen, Anu, Sunagawa, Kenji

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Comparison of solution-based exome capture methods for next generation sequencing von Sulonen, Anna-Maija, Ellonen, Pekka, Almusa, Henrikki, Lepistö, Maija, Eldfors, Samuli, Hannula, Sari, Miettinen, Timo, Tyynismaa, Henna, Salo, Perttu, Heckman, Caroline, Joensuu, Heikki, Raivio, Taneli, Suomalainen, Anu, Saarela, Janna

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High mitochondrial DNA copy number has detrimental effects in mice von Ylikallio, Emil, Tyynismaa, Henna, Tsutsui, Hiroyuki, Ide, Tomomi, Suomalainen, Anu

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Splicing Defect in Mitochondrial Seryl-tRNA Synthetase Gene Causes Progressive Spastic Paresis Instead of HUPRA Syndrome von Linnankivi, Tarja, Neupane, Nirajan, Richter, Uwe, Isohanni, Pirjo, Tyynismaa, Henna

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Disease models of mitochondrial aminoacyl-tRNA synthetase defects von Tyynismaa, Henna

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ATPase-deficient mitochondrial inner membrane protein ATAD3A disturbs mitochondrial dynamics in dominant hereditary spastic paraplegia von Cooper, Helen M, Yang, Yang, Ylikallio, Emil, Khairullin, Rafil, Woldegebriel, Rosa, Lin, Kai-Lan, Euro, Liliya, Palin, Eino, Wolf, Alexander, Trokovic, Ras, Isohanni, Pirjo, Kaakkola, Seppo, Auranen, Mari, Lönnqvist, Tuula, Wanrooij, Sjoerd, Tyynismaa, Henna

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Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice von Ahlqvist, Kati J., Hämäläinen, Riikka H., Yatsuga, Shuichi, Uutela, Marko, Terzioglu, Mügen, Götz, Alexandra, Forsström, Saara, Salven, Petri, Angers-Loustau, Alexandre, Kopra, Outi H., Tyynismaa, Henna, Larsson, Nils-Göran, Wartiovaara, Kirmo, Prolla, Tomas, Trifunovic, Aleksandra, Suomalainen, Anu

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Loss of MICOS complex integrity and mitochondrial damage, but not TDP-43 mitochondrial localisation, are likely associated with severity of CHCHD10-related diseases von Genin, Emmanuelle C., Bannwarth, Sylvie, Lespinasse, Françoise, Ortega-Vila, Bernardo, Fragaki, Konstantina, Itoh, Kie, Villa, Elodie, Lacas-Gervais, Sandra, Jokela, Manu, Auranen, Mari, Ylikallio, Emil, Mauri-Crouzet, Alessandra, Tyynismaa, Henna, Vihola, Anna, Augé, Gaelle, Cochaud, Charlotte, Sesaki, Hiromi, Ricci, Jean-Ehrland, Udd, Bjarne, Vives-Bauza, Cristofol, Paquis-Flucklinger, Véronique

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ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons von Harjuhaahto, Sandra, Rasila, Tiina S., Molchanova, Svetlana M., Woldegebriel, Rosa, Kvist, Jouni, Konovalova, Svetlana, Sainio, Markus T., Pennonen, Jana, Torregrosa-Muñumer, Rubén, Ibrahim, Hazem, Otonkoski, Timo, Taira, Tomi, Ylikallio, Emil, Tyynismaa, Henna

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Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria von Hilander, Taru, Zhou, Xiao-Long, Konovalova, Svetlana, Zhang, Fu-Ping, Euro, Liliya, Chilov, Dmitri, Poutanen, Matti, Chihade, Joseph, Wang, En-Duo, Tyynismaa, Henna

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TRIM2, a novel member of the antiviral family, limits New World arenavirus entry von Sarute, Nicolas, Ibrahim, Nouhou, Medegan Fagla, Bani, Lavanya, Madakasira, Cuevas, Christian, Stavrou, Spyridon, Otkiran-Clare, Guliz, Tyynismaa, Henna, Henao-Mejia, Jorge, Ross, Susan R

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Ketogenic diet slows down mitochondrial myopathy progression in mice von Ahola-Erkkilä, Sofia, Carroll, Christopher J., Peltola-Mjösund, Katja, Tulkki, Valtteri, Mattila, Ismo, Seppänen-Laakso, Tuulikki, Orešič, Matej, Tyynismaa, Henna, Suomalainen, Anu

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Dominant transmission of de novo KIF1A motor domain variant underlying pure spastic paraplegia von Ylikallio, Emil, Kim, Doyoun, Isohanni, Pirjo, Auranen, Mari, Kim, Eunjoon, Lönnqvist, Tuula, Tyynismaa, Henna

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Mutant Mitochondrial Helicase Twinkle Causes Multiple mtDNA Deletions and a Late-Onset Mitochondrial Disease in Mice von Henna Tyynismaa, Katja Peltola Mjosund, Sjoerd Wanrooij, Ilse Lappalainen, Emil Ylikallio, Anu Jalanko, Johannes N. Spelbrink, Anders Paetau, Suomalainen, Anu

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The Finnish genetic heritage in 2022 – from diagnosis to translational research von Uusimaa, Johanna, Kettunen, Johannes, Varilo, Teppo, Järvelä, Irma, Kallijärvi, Jukka, Kääriäinen, Helena, Laine, Minna, Lapatto, Risto, Myllynen, Päivi, Niinikoski, Harri, Rahikkala, Elisa, Suomalainen, Anu, Tikkanen, Ritva, Tyynismaa, Henna, Vieira, Päivi, Zarybnicky, Tomas, Sipilä, Petra, Kuure, Satu, Hinttala, Reetta

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Comparative whole-genome transcriptome analysis in renal cell populations reveals high tissue specificity of MAPK/ERK targets in embryonic kidney von Kurtzeborn, Kristen, Kwon, Hyuk Nam, Iaroshenko, Vladislav, Faisal, Imrul, Ambrož, Martin, Jin, Xing, Qureshi, Talha, Kupari, Jussi, Ihermann-Hella, Anneliis, Väänänen, Juho, Tyynismaa, Henna, Boušová, Iva, Park, Sunghyouk, Kuure, Satu

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Advances and challenges in modeling inherited peripheral neuropathies using iPSCs von Van Lent, Jonas, Prior, Robert, Pérez Siles, Gonzalo, Cutrupi, Anthony N., Kennerson, Marina L., Vangansewinkel, Tim, Wolfs, Esther, Mukherjee-Clavin, Bipasha, Nevin, Zachary, Judge, Luke, Conklin, Bruce, Tyynismaa, Henna, Clark, Alex J., Bennett, David L., Van Den Bosch, Ludo, Saporta, Mario, Timmerman, Vincent

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