NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells von Masters, Seth L., Gerlic, Motti, Metcalf, Donald, Preston, Simon, Pellegrini, Marc, O’Donnell, Joanne A., McArthur, Kate, Baldwin, Tracey M., Chevrier, Stephane, Nowell, Cameron J., Cengia, Louise H., Henley, Katya J., Collinge, Janelle E., Kastner, Daniel L., Feigenbaum, Lionel, Hilton, Douglas J., Alexander, Warren S., Kile, Benjamin T., Croker, Ben A.

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Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function von Schoenwaelder, Simone M., Yuan, Yuping, Josefsson, Emma C., White, Michael J., Yao, Yu, Mason, Kylie D., O'Reilly, Lorraine A., Henley, Katya J., Ono, Akiko, Hsiao, Sarah, Willcox, Abbey, Roberts, Andrew W., Huang, David C.S., Salem, Hatem H., Kile, Benjamin T., Jackson, Shaun P.

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The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells von Kile, Benjamin T, Loughran, Stephen J, Kruse, Elizabeth A, Hacking, Douglas F, de Graaf, Carolyn A, Hyland, Craig D, Willson, Tracy A, Henley, Katya J, Ellis, Sarah, Voss, Anne K, Metcalf, Donald, Hilton, Douglas J, Alexander, Warren S

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Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways von Josefsson, Emma C., Burnett, Deborah L., Lebois, Marion, Debrincat, Marlyse A., White, Michael J., Henley, Katya J., Lane, Rachael M., Moujalled, Diane, Preston, Simon P., O’Reilly, Lorraine A., Pellegrini, Marc, Metcalf, Donald, Strasser, Andreas, Kile, Benjamin T.

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ABCA12 Regulates ABCA1-Dependent Cholesterol Efflux from Macrophages and the Development of Atherosclerosis von Fu, Ying, Mukhamedova, Nigora, Ip, Sally, D’Souza, Wilissa, Henley, Katya J., DiTommaso, Tia, Kesani, Rajitha, Ditiatkovski, Michael, Jones, Lynelle, Lane, Rachael M., Jennings, Garry, Smyth, Ian M., Kile, Benjamin T., Sviridov, Dmitri

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Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia von Carmichael, Catherine L, Metcalf, Donald, Henley, Katya J, Kruse, Elizabeth A, Di Rago, Ladina, Mifsud, Sandra, Alexander, Warren S, Kile, Benjamin T

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Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease von Mason, Kylie D., Lin, Ann, Robb, Lorraine, Josefsson, Emma C., Henley, Katya J., Gray, Daniel H. D., Kile, Benjamin T., Roberts, Andrew W., Strasser, Andreas, Huang, David C. S., Waring, Paul, O'Reilly, Lorraine A.

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Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis von Cottle, Denny L, Ursino, Gloria M A, Ip, Sally Chi Ieng, Jones, Lynelle K, Ditommaso, Tia, Hacking, Douglas F, Mangan, Niamh E, Mellett, Natalie A, Henley, Katya J, Sviridov, Dmitri, Nold-Petry, Claudia A, Nold, Marcel F, Meikle, Peter J, Kile, Benjamin T, Smyth, Ian M

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Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia von Kile, Benjamin T., Panopoulos, Athanasia D., Stirzaker, Roslynn A., Hacking, Douglas F., Tahtamouni, Lubna H., Willson, Tracy A., Mielke, Lisa A., Henley, Katya J., Zhang, Jian-Guo, Wicks, Ian P., Stevenson, William S., Nurden, Paquita, Watowich, Stephanie S., Justice, Monica J.

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MyD88 is a critical regulator of hematopoietic cell-mediated neuroprotection seen after stroke von Downes, Catherine E, Wong, Connie H Y, Henley, Katya J, Guio-Aguilar, Pedro L, Zhang, Moses, Ates, Robert, Mansell, Ashley, Kile, Benjamin T, Crack, Peter J

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A model for studying the hemostatic consumption or destruction of platelets von Dowling, Mark R, Josefsson, Emma C, Henley, Katya J, Kile, Benjamin T, Hodgkin, Philip D

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Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor–induced thrombocytopenia von Bishton, Mark J., Harrison, Simon J., Martin, Benjamin P., McLaughlin, Nicole, James, Chloé, Josefsson, Emma C., Henley, Katya J., Kile, Benjamin T., Prince, H. Miles, Johnstone, Ricky W.

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Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets von Josefsson, Emma C, James, Chloé, Henley, Katya J, Debrincat, Marlyse A, Rogers, Kelly L, Dowling, Mark R, White, Michael J, Kruse, Elizabeth A, Lane, Rachael M, Ellis, Sarah, Nurden, Paquita, Mason, Kylie D, O'Reilly, Lorraine A, Roberts, Andrew W, Metcalf, Donald, Huang, David C S, Kile, Benjamin T

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Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion von Pleines, Irina, Lebois, Marion, Gangatirkar, Pradnya, Au, Amanda E., Lane, Rachael M., Henley, Katya J., Kauppi, Maria, Corbin, Jason, Cannon, Ping, Bernardini, Jonathan, Alwis, Imala, Jarman, Kate E., Ellis, Sarah, Metcalf, Donald, Jackson, Shaun P., Schoenwaelder, Simone M., Kile, Benjamin T., Josefsson, Emma C.

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Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function von White, Michael J., Schoenwaelder, Simone M., Josefsson, Emma C., Jarman, Kate E., Henley, Katya J., James, Chloé, Debrincat, Marlyse A., Jackson, Shaun P., Huang, David C.S., Kile, Benjamin T.

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Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival von Debrincat, Marlyse A., Josefsson, Emma C., James, Chloé, Henley, Katya J., Ellis, Sarah, Lebois, Marion, Betterman, Kelly L., Lane, Rachael M., Rogers, Kelly L., White, Michael J., Roberts, Andrew W., Harvey, Natasha L., Metcalf, Donald, Kile, Benjamin T.

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Platelet senescence is regulated by an internal timer, not damage inflicted by hits von Dowling, Mark R., Josefsson, Emma C., Henley, Katya J., Hodgkin, Philip D., Kile, Benjamin T.

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Extended Platelet In Vivo Survival Results in Exhausted Platelets von Pleines, Irina, Lebois, Marion, Au, Amanda E.-L., Lane, Rachael M., Henley, Katya J., Corbin, Jason, Cannon, Ping, Jarman, Kate E, Ellis, Sarah, Jackson, Shaun P, Schoenwaelder, Simone M., Kile, Benjamin T., Josefsson, Emma C.

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Hematopoietic Overexpression of the ETS Family Transcription Factor Erg, or the Oncogenic Fusion Protein TLS-ERG, Induces Erythro-Megakaryocytic Leukemia von Carmichael, Catherine L, Metcalf, Donald, Henley, Katya J., Kruse, Elizabeth A, Di Rago, Ladina, Mifsud, Sandra, Tang, Jian Zhong, Alexander, Warren S., Kile, Benjamin T.

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Platelet Production Occurs Independently of Both the Intrinsic and Extrinsic Apoptosis Pathways von Josefsson, Emma C., Burnett, Deborah L., Debrincat, Marlyse A., Henley, Katya J., Lane, Rachael M., Lebois, Marion, O'Reilly, Lorraine A., Pellegrini, Marc, Preston, Simon P., Croker, Ben A., Metcalf, Donald, Strasser, Andreas, Kile, Benjamin T.

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