Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity von Sebhat, Iyassu K, Franklin, Christopher, Lo, Michael M.-C, Chen, David, Jewell, James P, Miller, Randy, Pang, Jianmei, Palyha, Oksana, Kan, Yanqing, Kelly, Theresa M, Guan, Xiao-Ming, Marsh, Donald J, Kosinski, Jennifer A, Metzger, Joseph M, Lyons, Kathryn, Dragovic, Jasminka, Guzzo, Peter R, Henderson, Alan J, Reitman, Marc L, Nargund, Ravi P, Wyvratt, Matthew J, Lin, Linus S

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Targeting 5-HT receptors for the treatment of obesity von Sargent, Bruce J, Henderson, Alan J

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2,3-Diaminopyrazines as rho kinase inhibitors von Henderson, Alan J., Hadden, Mark, Guo, Cheng, Douglas, Neema, Decornez, Helene, Hellberg, Mark R., Rusinko, Andrew, McLaughlin, Marsha, Sharif, Naj, Drace, Colene, Patil, Raj

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Epiminocyclohepta[b]indole analogs as 5-HT6 antagonists von Henderson, Alan J., Guzzo, Peter R., Ghosh, Animesh, Kaur, Jagjit, Koo, Jia-Man, Nacro, Kassoum, Panduga, Shailaja, Pathak, Rashmi, Shimpukade, Bharat, Tan, Valentina, Xiang, Kai, Wierschke, Jonathan D., Isherwood, Matthew L.

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Synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1 H)ones as MCH-1 antagonists for the treatment of obesity von Hadden, Mark, Deering, Dustin M., Henderson, Alan J., Surman, Matthew D., Luche, Michele, Khmelnitsky, Yuri, Vickers, Steven, Viggers, Jean, Cheetham, Sharon, Guzzo, Peter R.

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5-(Pyridinon-1-yl)indazoles and 5-(furopyridinon-5-yl)indazoles as MCH-1 antagonists von Surman, Matthew D., Freeman, Emily E., Grabowski, James F., Hadden, Mark, Henderson, Alan J., Jiang, Guowei, Jiang, Xiaowu (May), Luche, Michele, Khmelnitsky, Yuri, Vickers, Steven, Viggers, Jean, Cheetham, Sharon, Guzzo, Peter R.

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Tetrahydrocarboline analogs as MCH-1 antagonists von Henderson, Alan J., Deering, Dustin, Grabowski, James F., Hadden, Mark, Jiang, Xiaowu, Khmelnitsky, Yuri, Luche, Michele, Surman, Matthew D., Cheetham, Sharon, Vickers, Steven, Viggers, Jean, Guzzo, Peter R.

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Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity von Liu, Jian, He, Shuwen, Jian, Tianying, Dobbelaar, Peter H., Sebhat, Iyassu K., Lin, Linus S., Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Hadden, Mark, Henderson, Alan J., Pattamana, Kevin, Ruenz, Megan, Sargent, Bruce J, Swenson, Brian, Yet, Larry, Tamvakopoulos, Constantin, Peng, Qianping, Pan, Jie, Kan, Yanqing, Palyha, Oksana, Kelly, Theresa M., Guan, Xiao-Ming, Howard, Andrew D., Marsh, Donald J., Metzger, Joseph M., Reitman, Marc L., Wyvratt, Matthew J., Nargund, Ravi P.

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Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity von Hadden, Mark, Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Henderson, Alan J., Pattamana, Kevin, Ruenz, Megan, Sargent, Bruce J., Swenson, Brian, Yet, Larry, Liu, Jian, He, Shuwen, Sebhat, Iyassu K., Lin, Linus S., Tamvakopoulos, Constantin, Peng, Qianping, Kan, Yanqing, Palyha, Oksana, Kelly, Theresa M., Guan, Xiao-Ming, Metzger, Joseph M., Reitman, Marc L., Nargund, Ravi P.

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Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists von He, Shuwen, Dobbelaar, Peter H., Liu, Jian, Jian, Tianying, Sebhat, Iyassu K., Lin, Linus S., Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Hadden, Mark, Henderson, Alan J., Ruenz, Megan, Sargent, Bruce J., Yet, Larry, Kelly, Theresa M., Palyha, Oksana, Kan, Yanqing, Pan, Jie, Chen, Howard, Marsh, Donald J., Shearman, Lauren P., Strack, Alison M., Metzger, Joseph M., Feighner, Scott D., Tan, Carina, Howard, Andrew D., Tamvakopoulos, Constantin, Peng, Qianping, Guan, Xiao-Ming, Reitman, Marc L., Patchett, Arthur A., Wyvratt, Matthew J., Nargund, Ravi P.

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An efficient synthesis of (7S,10R)-2-bromo-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole: application in the preparation and structural confirmation of a potent 5-HT6 anta... von Isherwood, Matthew L., Guzzo, Peter R., Henderson, Alan J., Hsia, Ming Min, Kaur, Jagjit, Nacro, Kassoum, Narreddula, Venkateswara R., Panduga, Shailaja, Pathak, Rashmi, Shimpukade, Bharat, Tan, Valentina, Xiang, Kai, Qiang, Zhu, Ghosh, Animesh

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The synthesis and SAR of novel diarylsulfone 11b-HSD1 inhibitors von Hadden, Mark, Deering, Dustin M, Henderson, Alan J, Surman, Matthew D, Luche, Michele, Khmelnitsky, Yuri, Vickers, Steven, Viggers, Jean, Cheetham, Sharon, Guzzo, Peter R

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Valve access conduit assembly and method of installing the assembly von Roell Joseph, Henderson Alan J

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Valve access conduit assembly and method of installing the assembly von Roell Joseph, Henderson Alan J

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Valve access conduit assembly and method of installing the assembly von Roell Joseph, Henderson Alan J

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Valve access conduit assembly and method of installing the assembly von Roell Joseph, Henderson Alan J

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VALVE ACCESS CONDUIT ASSEMBLY AND METHOD OF INSTALLING THE ASSEMBLY von Roell Joseph, Henderson Alan J

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PYRIDO-/AZEPINO-BENZOFURAN AND PYRIDO-/AZEPINO-BENZOTHIOPHENE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF von GUZZO PETER R, SURMAN MATTHEW D, FREEMAN EMILY E, HADDEN MARK, HENDERSON ALAN J

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Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia von GUZZO PETER R, ISHERWOOD MATTHEW, LEE CHONG YEW, GHOSH ANIMESH, ZHAO HE, HENDERSON ALAN J

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Unprecedented ring expansion of [60]fullerene: incorporation of nitrogen at an open 6,6-ring juncture by regiospecific reduction of oxycarbonylaziridino-[2′,3′:1,2][60]fullerenes.... von Banks, Malcolm R., Cadogan, J. I. G., Gosney, Ian, Henderson, Alan J., Hodgson, Philip K. G., Kerr, Wesley G., Kerth, Andreas, Langridge-Smith, Patrick R. R., Millar, John R. A., Mount, Andrew R., Parkinson, John A., Taylor, Alan T., Thornburn, Paul

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