Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy? von Yamanaka, Kinrin, Chatterjee, Nimrat, Hemann, Michael T, Walker, Graham C

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A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses von Bent, Eric H, Gilbert, Luke A, Hemann, Michael T

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A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress von Bruno, Peter M, Liu, Yunpeng, Park, Ga Young, Murai, Junko, Koch, Catherine E, Eisen, Timothy J, Pritchard, Justin R, Pommier, Yves, Lippard, Stephen J, Hemann, Michael T

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The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning von Bruno, Peter M., Lu, Mengrou, Dennis, Kady A., Inam, Haider, Moore, Connor J., Sheehe, John, Elledge, Stephen J., Hemann, Michael T., Pritchard, Justin R.

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Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy von Bent, Eric H., Millán-Barea, Luis R., Zhuang, Iris, Goulet, Daniel R., Fröse, Julia, Hemann, Michael T.

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Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma von Braun, Christian J., Stanciu, Monica, Boutz, Paul L., Patterson, Jesse C., Calligaris, David, Higuchi, Fumi, Neupane, Rachit, Fenoglio, Silvia, Cahill, Daniel P., Wakimoto, Hiroaki, Agar, Nathalie Y.R., Yaffe, Michael B., Sharp, Phillip A., Hemann, Michael T., Lees, Jacqueline A.

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Intratumor heterogeneity alters most effective drugs in designed combinations von Zhao, Boyang, Hemann, Michael T., Lauffenburger, Douglas A.

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Sensitizing Protective Tumor Microenvironments to Antibody-Mediated Therapy von Pallasch, Christian P., Leskov, Ilya, Braun, Christian J., Vorholt, Daniela, Drake, Adam, Soto-Feliciano, Yadira M., Bent, Eric H., Schwamb, Janine, Iliopoulou, Bettina, Kutsch, Nadine, van Rooijen, Nico, Frenzel, Lukas P., Wendtner, Clemens M., Heukamp, Lukas, Kreuzer, Karl Anton, Hallek, Michael, Chen, Jianzhu, Hemann, Michael T.

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Rev7 loss alters cisplatin response and increases drug efficacy in chemotherapy-resistant lung cancer von Vassel, Faye-Marie, Bian, Ke, Walker, Graham C., Hemann, Michael T.

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Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution von Zhao, Boyang, Sedlak, Joseph C., Srinivas, Raja, Creixell, Pau, Pritchard, Justin R., Tidor, Bruce, Lauffenburger, Douglas A., Hemann, Michael T.

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Error-prone translesion synthesis mediates acquired chemoresistance von Xie, Kun, Doles, Jason, Hemann, Michael T., Walker, Graham C., Lehmann, Alan R.

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Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation von Braun, Christian J., Bruno, Peter M., Horlbeck, Max A., Gilbert, Luke A., Weissman, Jonathan S., Hemann, Michael T.

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Defining principles of combination drug mechanisms of action von Pritchard, Justin R, Bruno, Peter M, Gilbert, Luke A, Capron, Kelsey L, Lauffenburger, Douglas A, Hemann, Michael T

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Stage-specific sensitivity to p53 restoration during lung cancer progression von Jacks, Tyler, Feldser, David M, Kostova, Kamena K, Winslow, Monte M, Taylor, Sarah E, Cashman, Chris, Whittaker, Charles A, Sanchez-Rivera, Francisco J, Resnick, Rebecca, Bronson, Roderick, Hemann, Michael T

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Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer von Qi, Ruogu, Wang, Yongheng, Bruno, Peter M., Xiao, Haihua, Yu, Yingjie, Li, Ting, Lauffer, Sam, Wei, Wei, Chen, Qixian, Kang, Xiang, Song, Haiqin, Yang, Xi, Huang, Xing, Detappe, Alexandre, Matulonis, Ursula, Pepin, David, Hemann, Michael T., Birrer, Michael J., Ghoroghchian, P. Peter

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Integrated regulatory models for inference of subtype‐specific susceptibilities in glioblastoma von Liu, Yunpeng, Shi, Ning, Regev, Aviv, He, Shan, Hemann, Michael T

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The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia von Fenouille, Nina, Bassil, Christopher F, Ben-Sahra, Issam, Benajiba, Lina, Alexe, Gabriela, Ramos, Azucena, Pikman, Yana, Conway, Amy S, Burgess, Michael R, Li, Qing, Luciano, Frédéric, Auberger, Patrick, Galinsky, Ilene, DeAngelo, Daniel J, Stone, Richard M, Zhang, Yi, Perkins, Archibald S, Shannon, Kevin, Hemann, Michael T, Puissant, Alexandre, Stegmaier, Kimberly

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REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks von Chatterjee, Nimrat, Whitman, Matthew A., Harris, Cynthia A., Min, Sophia M., Jonas, Oliver, Lien, Evan C., Luengo, Alba, Vander Heiden, Matthew G., Hong, Jiyong, Zhou, Pei, Hemann, Michael T., Walker, Graham C.

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A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy von Cannell, Ian G., Merrick, Karl A., Morandell, Sandra, Zhu, Chang-Qi, Braun, Christian J., Grant, Robert A., Cameron, Eleanor R., Tsao, Ming-Sound, Hemann, Michael T., Yaffe, Michael B.

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Simultaneous screening of overexpressed genes in breast cancer for oncogenic drivers and tumor dependencies von Mofunanya, Adaobi, Cameron, Eleanor R., Braun, Christian J., Celeste, Frank, Zhao, Xiaoyu, Hemann, Michael T., Scott, Kenneth L., Li, Jinyu, Powers, Scott

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