The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML von Vetrie, David, Helgason, G. Vignir, Copland, Mhairi

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Mitochondrial metabolism as a potential therapeutic target in myeloid leukaemia von de Beauchamp, Lucie, Himonas, Ekaterini, Helgason, G. Vignir

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Folate metabolism: a re-emerging therapeutic target in haematological cancers von Zarou, Martha M., Vazquez, Alexei, Vignir Helgason, G.

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Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells von Kuntz, Elodie M, Baquero, Pablo, Michie, Alison M, Dunn, Karen, Tardito, Saverio, Holyoake, Tessa L, Helgason, G Vignir, Gottlieb, Eyal

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Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival von Hamilton, Ashley, Helgason, G. Vignir, Schemionek, Mirle, Zhang, Bin, Myssina, Svetlana, Allan, Elaine K., Nicolini, Franck E., Müller-Tidow, Carsten, Bhatia, Ravi, Brunton, Valerie G., Koschmieder, Steffen, Holyoake, Tessa L.

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Kill one bird with two stones: potential efficacy of BCR-ABL and autophagy inhibition in CML von Helgason, G. Vignir, Karvela, Maria, Holyoake, Tessa L.

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Do we need more drugs for chronic myeloid leukemia? von Holyoake, Tessa L., Helgason, G. Vignir

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Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells von Rattigan, Kevin M., Brabcova, Zuzana, Sarnello, Daniele, Zarou, Martha M., Roy, Kiron, Kwan, Ryan, de Beauchamp, Lucie, Dawson, Amy, Ianniciello, Angela, Khalaf, Ahmed, Kalkman, Eric R., Scott, Mary T., Dunn, Karen, Sumpton, David, Michie, Alison M., Copland, Mhairi, Tardito, Saverio, Gottlieb, Eyal, Vignir Helgason, G.

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Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells von Bellodi, Cristian, Lidonnici, Maria Rosa, Hamilton, Ashley, Helgason, G Vignir, Soliera, Angela Rachele, Ronchetti, Mattia, Galavotti, Sara, Young, Kenneth W, Selmi, Tommaso, Yacobi, Rinat, Van Etten, Richard A, Donato, Nick, Hunter, Ann, Dinsdale, David, Tirrò, Elena, Vigneri, Paolo, Nicotera, Pierluigi, Dyer, Martin J, Holyoake, Tessa, Salomoni, Paolo, Calabretta, Bruno

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hsa-mir183/EGR1–mediated regulation of E2F1 is required for CML stem/progenitor cell survival von Pellicano, Francesca, Park, Laura, Hopcroft, Lisa E.M., Shah, Mansi M., Jackson, Lorna, Scott, Mary T., Clarke, Cassie J., Sinclair, Amy, Abraham, Sheela A., Hair, Alan, Helgason, G. Vignir, Aspinall-O'Dea, Mark, Bhatia, Ravi, Leone, Gustavo, Kranc, Kamil R., Whetton, Anthony D., Holyoake, Tessa L.

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Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing von Zarou, Martha M., Rattigan, Kevin M., Sarnello, Daniele, Shokry, Engy, Dawson, Amy, Ianniciello, Angela, Dunn, Karen, Copland, Mhairi, Sumpton, David, Vazquez, Alexei, Helgason, G. Vignir

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The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors von Pellicano, Francesca, Scott, Mary T., Helgason, G. Vignir, Hopcroft, Lisa E. M., Allan, Elaine K., Aspinall‐O'Dea, Mark, Copland, Mhairi, Pierce, Andrew, Huntly, Brian J. P., Whetton, Anthony D., Holyoake, Tessa L.

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Autophagy in blood cancers: biological role and therapeutic implications von Nencioni, Alessio, Cea, Michele, Montecucco, Fabrizio, Longo, Valter D, Patrone, Franco, Carella, Angelo M, Holyoake, Tessa L, Helgason, G Vignir

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Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche von Dawson, Amy, Zarou, Martha M., Prasad, Bodhayan, Bittencourt-Silvestre, Joana, Zerbst, Désirée, Himonas, Ekaterini, Hsieh, Ya-Ching, van Loon, Isabel, Blanco, Giovanny Rodriguez, Ianniciello, Angela, Kerekes, Zsombor, Krishnan, Vaidehi, Agarwal, Puneet, Almasoudi, Hassan, McCluskey, Laura, Hopcroft, Lisa E. M., Scott, Mary T., Baquero, Pablo, Dunn, Karen, Vetrie, David, Copland, Mhairi, Bhatia, Ravi, Coffelt, Seth B., Tiong, Ong Sin, Wheadon, Helen, Zanivan, Sara, Kirschner, Kristina, Helgason, G. Vignir

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Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death von Woodley, Keith, Dillingh, Laura S., Giotopoulos, George, Madrigal, Pedro, Rattigan, Kevin M., Philippe, Céline, Dembitz, Vilma, Magee, Aoife M. S., Asby, Ryan, van de Lagemaat, Louie N., Mapperley, Christopher, James, Sophie C., Prehn, Jochen H. M., Tzelepis, Konstantinos, Rouault-Pierre, Kevin, Vassiliou, George S., Kranc, Kamil R., Helgason, G. Vignir, Huntly, Brian J. P., Gallipoli, Paolo

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Axl Blockade by BGB324 Inhibits BCR-ABL Tyrosine Kinase Inhibitor-Sensitive and -Resistant Chronic Myeloid Leukemia von Ben-Batalla, Isabel, Erdmann, Robert, Jørgensen, Heather, Mitchell, Rebecca, Ernst, Thomas, von Amsberg, Gunhild, Schafhausen, Philippe, Velthaus, Janna L, Rankin, Stephen, Clark, Richard E, Koschmieder, Steffen, Schultze, Alexander, Mitra, Subir, Vandenberghe, Peter, Brümmendorf, Tim H, Carmeliet, Peter, Hochhaus, Andreas, Pantel, Klaus, Bokemeyer, Carsten, Helgason, G Vignir, Holyoake, Tessa L, Loges, Sonja

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Unraveling Heterogeneity in the Aging Hematopoietic Stem Cell Compartment: An Insight From Single‐cell Approaches von Yang, Fei, Nourse, Craig, Helgason, G. Vignir, Kirschner, Kristina

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BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia von Smith, Lindsay D., Minton, Annabel R., Blunt, Matthew D., Karydis, Laura I., Dutton, David A., Rogers-Broadway, Karly-Rai, Dobson, Rachel, Liu, Rena, Norster, Faith, Hogg, Elizabeth, Ashton-Key, Margaret, Strefford, Jonathan C., Jia, Li, Efremov, Dimitar G., Helgason, G. Vignir, Johnson, Peter W. M., Stevenson, Freda K., Forconi, Francesco, Cragg, Mark S., Tumbarello, David A., Packham, Graham, Steele, Andrew J.

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Targeting ULK1 in cancer stem cells: insight from chronic myeloid leukemia von Ianniciello, Angela, Helgason, G. Vignir

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BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia von Parry, Narissa, Busch, Caroline, Aßmann, Victoria, Cassels, Jennifer, Hair, Alan, Helgason, G. Vignir, Wheadon, Helen, Copland, Mhairi

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