3431 Vorinostat in locally advanced and metastastic soft tissue sarcomas - results of a multi-center phase II trial (SAHA-1) of the German Sarcoma and GIST Working Group (AIO) von Schmitt, T, Mayer-Steinacker, R, Mayer, F, Grünwald, V, schütte, J, Hartmann, J.T, Kasper, B, Hüsing, J, Hajda, J, Ottawa, G, Heilig, C.E, Ho, A.D, Egerer, G

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56P Multi-omic profiling in cholangiocarcinoma to enable scientific advancement within the DKFZ/NCT/DKTK MASTER study von Nichetti, F., Korell, F., Schwab, M., Hoffmeister, P.K.M., Hüllein, J., Uhrig, S., Teleanu, M-V., Kreutzfeldt, S., Horak, P., Glimm, H., Heining, C., Rieke, D.T., Kindler, T., Hübschmann, D., Springfeld, C., Jenzer, M., Heilig, C.E., Fröhling, S., Köhler, B.C.

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2318P Value of broad molecular profiling for cancer diagnosis von Werstein, L.V.A., Heilig, C.E., Teleanu, M-V., Hüllein, J., Singh, M., Bauer, S., Kindler, T., Klauschen, F., Brandts, C.H., Rieke, D.T., Illert, L., Börries, M., Kreutzfeldt, S., Horak, P., Hübschmann, D., Lipka, D.B., Glimm, H., Hartmann, W., Fröhling, S.

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131O A composite biomarker for evaluation of homologous recombination repair deficiency in a pan-cancer cohort von Rübsam, M., Rheinnecker, M., Hutter, B., Fröhlich, M., Heilig, C.E., Paramasivam, N., Oleś, M., Ball, C., Glimm, H., Hlevnjak, M., Zapatka, M., Lichter, P., Fröhling, S., Schlenk, R.F., Hübschmann, D.

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1936P Targeted therapy of desmoplastic small round cell tumor guided by multilayered molecular profiling von Renner, M., Oleś, M., Paramasivam, N., Schneider, A., Heilig, C.E., Modugno, C., Herremans, C., Mock, A., Lipka, D., Bauer, S., Kindler, T., Brandts, C.H., Keilholz, U., Boerries, M., Kuster, B., Hübschmann, D., Schlesner, M., Glimm, H., Schlenk, R.F., Fröhling, S.

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Comprehensive cancer predisposition testing within the prospective MASTER trial identifies hereditary cancer patients and supports treatment decisions for rare cancers von Jahn, A., Rump, A., Widmann, T.J., Heining, C., Horak, P., Hutter, B., Paramasivam, N., Uhrig, S., Gieldon, L., Drukewitz, S., Kübler, A., Bermudez, M., Hackmann, K., Porrmann, J., Wagner, J., Arlt, M., Franke, M., Fischer, J., Kowalzyk, Z., William, D., Weth, V., Oster, S., Fröhlich, M., Hüllein, J., Valle González, C., Kreutzfeldt, S., Mock, A., Heilig, C.E., Lipka, D.B., Möhrmann, L., Hanf, D., Oleś, M., Teleanu, V., Allgäuer, M., Ruhnke, L., Kutz, O., Knurr, A., Laßmann, A., Endris, V., Neumann, O., Penzel, R., Beck, K., Richter, D., Winter, U., Wolf, S., Pfütze, K., Geörg, C., Meißburger, B., Buchhalter, I., Augustin, M., Aulitzky, W.E., Hohenberger, P., Kroiss, M., Schirmacher, P., Schlenk, R.F., Keilholz, U., Klauschen, F., Folprecht, G., Bauer, S., Siveke, J.T., Brandts, C.H., Kindler, T., Boerries, M., Illert, A.L., von Bubnoff, N., Jost, P.J., Metzeler, K.H., Bitzer, M., Schulze-Osthoff, K., von Kalle, C., Brors, B., Stenzinger, A., Weichert, W., Hübschmann, D., Fröhling, S., Glimm, H., Schröck, E., Klink, B.

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1772P Phosphoproteomic biomarker for afatinib response stratification in advanced chordoma von Stange, C., Schneider, A., Jensen, C.B., Sakhteman, A., Teleanu, M-V., Horak, P., Kreutzfeldt, S., Oles, M., Heilig, C.E., Punturi, N., Dolat, L., Resch, M., Hamood, F., Herold-Mende, C., Hübschmann, D., Wilhelm, S., Freed, D.M., The, M., Fröhling, S., Kuster, B.

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1784TiP Pasireotide as maintenance treatment in SSTR2/3/5-expressing synovial sarcoma and desmoplastic small round cell tumor: The PAMSARC study von Schlenk, R.F., Heining, C., Gnutzmann, E., Roldan, S.S.L., Heiligenthal, L., Sparber Sauer, M., Hahn, D.A., Dirksen, U., Hamacher, R.W., Floercken, A., Thorwarth, A., Deinzer, C., Gaidzik, V., van Tilburg, C.M., Hübschmann, D., Arndt, K., Pfister, S.M., Glimm, H., Fröhling, S., Heilig, C.E.

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198P Inavolisib in cancers with activating PIK3CA mutations: Results from the CRAFT trial von Heilig, C.E., Teleanu, M-V., Desuki, A., Kindler, T., Deschler, B., Kunzmann, V., von Bubnoff, N., Illert, L., Rieke, D.T., Süsse, H., Heiligenthal, L., Kreutzfeldt, S., Horak, P., Steindorf, K., Benner, A., Hübschmann, D., Schweigert, N., Glimm, H., Fröhling, S., Schlenk, R.F.

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196P Randomized phase II study of trabectedin/olaparib compared to physician’s choice in subjects with previously treated advanced or recurrent solid tumors harboring DNA repair de... von Schlenk, R.F., Rübsam, M., Teleanu, M-V., Richter, S., Siveke, J.T., Wagner, S., Kopp, H-G., Kindler, T., Illert, L., Golf, A.H-E., Dorman, K., Schreck, N., Benner, A., Süsse, H., Freitag, A., von Kalle, C., Glimm, H., Hübschmann, D., Fröhling, S., Heilig, C.E.

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487P Randomized phase II study of trabectedin/olaparib compared to physician’s choice in subjects with previously treated advanced or recurrent solid tumors harboring DNA repair de... von Heilig, C.E., Teleanu, M-V., Bhatti, I.A., Richter, S., Siveke, J.T., Wagner, S., Kopp, H-G., Kindler, T., Illert, L., Golf, A., Dormann, K., Benner, A., Süsse, H., Freitag, A., Von Kalle, C., Glimm, H., Hübschmann, D., Fröhling, S., Schlenk, R.F.

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1490MO CDK4/6 inhibition in locally advanced/metastatic chordoma (NCT PMO-1601) von Teleanu, M-V., Heilig, C.E., Hamacher, R.W., Bauer, S., Mayer-Steinacker, R., Gaidzik, V.I., Horak, P., Lanz, L-M., Muskatewitz, T., Süsse, H., Freitag, A., von Hornung, M., Wacker, L., Von Kalle, C., Barth, T., Fröhling, S., Schlenk, R.F.

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187P Ipatasertib and atezolizumab in cancers with increased PI3K-AKT pathway activity: First results from the CRAFT trial von Heilig, C.E., Singh, M., Teleanu, M-V., Desuki, A., Kindler, T., Bitzer, M., Baier, B.D., Kunzmann, V., von Bubnoff, N., Süsse, H., Heiligenthal, L., Steindorf, K., Benner, A., Kreutzfeldt, S., Heining, C., Horak, P., Hübschmann, D., Glimm, H., Fröhling, S., Schlenk, R.F.

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1940P Deep molecular profiling of advanced synovial sarcoma as a basis for interventional clinical trials von Schlenk, R.F., Oleś, M., Bauer, S., Kindler, T., Klauschen, F., Brandts, C.H., Rieke, D.T., Illert, L., Börries, M., Heining, C., Horak, P., Bitzer, M., Dirksen, U., Sparber-Sauer, M., Teleanu, M-V., Kreutzfeldt, S., Glimm, H., Hübschmann, D., Heilig, C.E., Fröhling, S.

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1533P Gene expression-based prediction of pazopanib benefit in sarcomas von Lassmann, A., Heilig, C.E., Mughal, S.S., Pirmann, S., Mock, A., Andresen, C., Aybey, B., Bauer, S., Brandts, C., Horak, P., Lipka, D., Kreutzfeldt, S., Teleanu, M.V., Heining, C., Brors, B., Glimm, H., Hübschmann, D., Fröhling, S.

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Community-driven development of a modified progression-free survival ratio for precision oncology trials von Mock, A., Heilig, C.E., Kreutzfeldt, S., Hübschmann, D., Heining, C., Schröck, E., Brors, B., Stenzinger, A., Jäger, D., Schlenk, R.F., Glimm, H., Fröhling, S., Horak, P.

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Pretreatment d-2-hydroxyglutarate serum levels negatively impact on outcome in IDH1-mutated acute myeloid leukemia von Balss, J, Thiede, C, Bochtler, T, Okun, J G, Saadati, M, Benner, A, Pusch, S, Ehninger, G, Schaich, M, Ho, A D, von Deimling, A, Krämer, A, Heilig, C E

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Comprehensive genomic and transcriptomic profiling in advanced-stage cancers and rare malignancies: Clinical results from the MASTER trial of the German Cancer Consortium von Horak, P., Kreutzfeldt, S., Mock, A., Heining, C., Heilig, C.E., Möhrmann, L., Uhrig, S., Hübschmann, D., Beck, K., Richter, D., Schlenk, R.F., Klink, B., Hutter, B., Weichert, W., Stenzinger, A., Schröck, E., Brors, B., Glimm, H., Fröhling, S.

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Clinical outcome of personalised treatment guided by genome and transcriptome sequencing in patients with neuroendocrine neoplasms: Updated results from the German NCT/DKTK MASTER... von Kreutzfeldt, S., Apostolidis, L., Oles, M., Horak, P., Heilig, C.E., Heining, C., Hutter, B., Klink, B., Lamping, M., Uhrig, S., Stenzinger, A., Winkler, E.C., Wiedenmann, B., Jäger, D., Brors, B., Schröck, E., Keilholz, U., Pavel, M.E., Glimm, H., Fröhling, S.

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Randomized phase II study of trabectedin/olaparib compared to physician’s choice in subjects with previously treated advanced or recurrent solid tumors harboring dna repair deficie... von Heilig, C.E., Hübschmann, D., Kopp, H.-G., Metzeler, K.H., Richter, S., Hermes, B., von Bubnoff, N., Kindler, T., Siveke, J., Wagner, S., Ochsenreither, S., Süße, H., Brors, B., Benner, A., Jäger, D., Von Kalle, C., Glimm, H., Gröschel, S., Fröhling, S., Schlenk, R.F.

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