Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington’s Disease von Liu, Longbin, Malagu, Karine, Haughan, Alan F., Khetarpal, Vinod, Stott, Andrew J., Esmieu, William, Vater, Huw D., Webster, Stephen J., Van de Poël, Amanda J., Clissold, Cole, Cosgrove, Brett, Sutton, Benjamin, Spencer, Jonathan A., Breccia, Perla, Gancia, Emanuela, Bonomo, Silvia, Ladduwahetty, Tammy, Lazari, Ovadia, Patel, Hiral, Atton, Helen C., Clifton, Steve, Mota, Daniel M., Magnani, Dario, O’Neill, Amy, Stebbeds, Marta, Macabuag, Natsuko, Todd, Daniel, Herva, Maria E., Mitchell, Philip, Visser, Mijke, Compte Sancerni, Sara, Grand Moursel, Laure, da Silva, Marta, Kritikou, Eva, Heikkinen, Taneli T., Bolkvadze, Tamuna, Fodale, Valentina, Spadafora, Debora, Daldin, Manuel, Bresciani, Alberto, Mangette, John E., Doherty, Elizabeth M., Lee, Matthew R., Herbst, Todd, Monteagudo, Edith, Macdonald, Douglas, Plotnikov, Nikolay V., Chambers, Mark, McAllister, George, Muňoz-Sanjuan, Ignacio, Dominguez, Celia

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Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease von Heikkinen, Taneli, Lehtimäki, Kimmo, Vartiainen, Nina, Puoliväli, Jukka, Hendricks, Susan J, Glaser, Jack R, Bradaia, Amyaouch, Wadel, Kristian, Touller, Chrystelle, Kontkanen, Outi, Yrjänheikki, Juha M, Buisson, Bruno, Howland, David, Beaumont, Vahri, Munoz-Sanjuan, Ignacio, Park, Larry C

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Rapid and robust patterns of spontaneous locomotor deficits in mouse models of Huntington's disease von Heikkinen, Taneli, Bragge, Timo, Bhattarai, Niina, Parkkari, Teija, Puolivali, Jukka, Kontkanen, Outi, Sweeney, Patrick, Park, Larry C., Munoz-Sanjuan, Ignacio

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Global Rhes knockout in the Q175 Huntington's disease mouse model von Heikkinen, Taneli, Bragge, Timo, Kuosmanen, Juha, Parkkari, Teija, Gustafsson, Sanna, Kwan, Mei, Beltran, Jose, Ghavami, Afshin, Subramaniam, Srinivasa, Shahani, Neelam, Ramirez-Jarquin, Uri Nimrod, Park, Larry, Munoz-Sanjuan, Ignacio, Marchionini, Deanna M.

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The expanded CAG repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the HD mouse brain von Datson, Nicole A, González-Barriga, Anchel, Kourkouta, Eleni, Weij, Rudie, van de Giessen, Jeroen, Mulders, Susan, Kontkanen, Outi, Heikkinen, Taneli, Lehtimäki, Kimmo, van Deutekom, Judith C T

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Physiological and behavioural implications of the portosystemic shunt in C57Bl/6J mice von Lehtimäki, Kimmo K., Rytkönen, Jussi, Pussinen, Raimo, Shatillo, Artem, Bragge, Timo, Heikkinen, Taneli, Fischer, David F., Kopanitsa, Maksym V., Sweeney, Patrick, Nurmi, Antti, Puoliväli, Jukka

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Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease von Zeitler, Bryan, Froelich, Steven, Marlen, Kimberly, Shivak, David A, Yu, Qi, Li, Davis, Pearl, Jocelynn R, Miller, Jeffrey C, Zhang, Lei, Paschon, David E, Hinkley, Sarah J, Ankoudinova, Irina, Lam, Stephen, Guschin, Dmitry, Kopan, Lexi, Cherone, Jennifer M, Nguyen, Hoang-Oanh B, Qiao, Guijuan, Ataei, Yasaman, Mendel, Matthew C, Amora, Rainier, Surosky, Richard, Laganiere, Josee, Vu, B Joseph, Narayanan, Anand, Sedaghat, Yalda, Tillack, Karsten, Thiede, Christina, Gärtner, Annette, Kwak, Seung, Bard, Jonathan, Mrzljak, Ladislav, Park, Larry, Heikkinen, Taneli, Lehtimäki, Kimmo K, Svedberg, Marie M, Häggkvist, Jenny, Tari, Lenke, Tóth, Miklós, Varrone, Andrea, Halldin, Christer, Kudwa, Andrea E, Ramboz, Sylvie, Day, Michelle, Kondapalli, Jyothisri, Surmeier, D James, Urnov, Fyodor D, Gregory, Philip D, Rebar, Edward J, Muñoz-Sanjuán, Ignacio, Zhang, H Steve

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Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington’s Disease Models von Beaumont, Vahri, Zhong, Sheng, Lin, Hai, Xu, WenJin, Bradaia, Amyaouch, Steidl, Esther, Gleyzes, Melanie, Wadel, Kristian, Buisson, Bruno, Padovan-Neto, Fernando E., Chakroborty, Shreaya, Ward, Karen M., Harms, John F., Beltran, Jose, Kwan, Mei, Ghavami, Afshin, Häggkvist, Jenny, Tóth, Miklós, Halldin, Christer, Varrone, Andrea, Schaab, Christoph, Dybowski, J. Nikolaj, Elschenbroich, Sarah, Lehtimäki, Kimmo, Heikkinen, Taneli, Park, Larry, Rosinski, James, Mrzljak, Ladislav, Lavery, Daniel, West, Anthony R., Schmidt, Christopher J., Zaleska, Margaret M., Munoz-Sanjuan, Ignacio

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Vertigoheel promotes rodent cognitive performance in multiple memory tests von Ott, Kerstin, Heikkinen, Taneli, Lehtimäki, Kimmo K, Paldanius, Kaisa, Puoliväli, Jukka, Pussinen, Raimo, Andriambeloson, Emile, Huyard, Bertrand, Wagner, Stéphanie, Schnack, Cathrin, Wahler, Anke, von Einem, Bjoern, von Arnim, Christine A F, Burmeister, Yvonne, Weyer, Kathrin, Seilheimer, Bernd

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Characterization of behavioral changes, MRI brain volumetry and brain metabolic profile of 5xFAD mouse model of Alzheimer’s disease von Heikkinen, Taneli, Karhunen, Petri, Stenius, Taina‐Kaisa, Kosunen, Henni, Lehtimäki, Kimmo, Shatillo, Artem, Oksman, Juho, Dudek, Mateusz, Miszczuk, Diana

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Improving the properties of wood–plastic composite through addition of hardwood pyrolysis liquid von Väisänen, Taneli, Heikkinen, Jorma, Tomppo, Laura, Lappalainen, Reijo

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The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease von Beaumont, Vahri, Mrzljak, Ladislav, Dijkman, Ulrike, Freije, Robert, Heins, Mariette, Rassoulpour, Arash, Tombaugh, Geoffrey, Gelman, Simon, Bradaia, Amyaouch, Steidl, Esther, Gleyzes, Melanie, Heikkinen, Taneli, Lehtimäki, Kimmo, Puoliväli, Jukka, Kontkanen, Outi, Javier, Robyn M., Neagoe, Ioana, Deisemann, Heike, Winkler, Dirk, Ebneth, Andreas, Khetarpal, Vinod, Toledo-Sherman, Leticia, Dominguez, Celia, Park, Larry C., Munoz-Sanjuan, Ignacio

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Evidences for Mutant Huntingtin Inducing Musculoskeletal and Brain Growth Impairments via Disturbing Testosterone Biosynthesis in Male Huntington Disease Animals von Yu-Taeger, Libo, Novati, Arianna, Weber, Jonasz Jeremiasz, Singer-Mikosch, Elisabeth, Pabst, Ann-Sophie, Cheng, Fubo, Saft, Carsten, Koenig, Jennifer, Ellrichmann, Gisa, Heikkinen, Taneli, Pouladi, Mahmoud A, Riess, Olaf, Nguyen, Huu Phuc

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Impaired Performance of the Q175 Mouse Model of Huntington's Disease in the Touch Screen Paired Associates Learning Task von Piiponniemi, Tuukka O, Parkkari, Teija, Heikkinen, Taneli, Puoliväli, Jukka, Park, Larry C, Cachope, Roger, Kopanitsa, Maksym V

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High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases von Youssef, Omar, Plenge, Robert, Ehm, Margaret G., Auro, Kirsi, Longerich, Simonne, Chatelain, Clement, Kaprio, Jaakko, Virolainen, Petri, Raivio, Taneli, Tikkanen, Jani, Kosma, Veli-Matti, Laukkanen, Jari, Ding, Zhihao, Hu, Xinli, Hedman, Åsa, Renaud, Nicole, Obeidat, Maen, Ripatti, Samuli, Arvas, Mikko, Hinttala, Reetta, Kettunen, Johannes, Mäkelä, Johanna, Hiltunen, Mikko, Peltola, Jukka, Raivio, Minna, Partanen, Juulia, Abbasi, Ali, Eaton, Susan, Xu, Fanli, Addis, Laura, Eicher, John, Pikkarainen, Sampsa, Jussila, Airi, Voutilainen, Markku, Miller, Jason, Miller, Melissa, Eklund, Kari, Lertratanakul, Apinya, Pelkonen, Margit, Mouded, Majd, Ngo, Debby, Niiranen, Teemu, Aittokallio, Jenni, Hernesniemi, Jussi, Hiltunen, Timo, Reeve, Mary Pat, Mattson, Johanna, Auranen, Annika, Auvinen, Päivi, Fabre, Margarete, Kulkarni, Diptee, Loboda, Andrey, Ollila, Terhi, Loomis, Stephanie, Hannula-Jouppi, Katariina, Salmi, Teea, Pussinen, Pirkko, Salo, Tuula, Siponen, Maria, Mäntylä, Päivi, Anttonen, Vuokko, Kotaniemi-Talonen, Laura, Välimäki, Niko, Laakkonen, Eija, Laisk, Triin, Hovatta, Iiris, Isometsä, Erkki, Ollila, Hanna, Mäkitie, Antti, Aarnisalo, Antti, Aittomäki, Kristiina, Havulinna, Aki, Della Briotta Parolo, Pietro, Liu, Aoxing, Ganna, Andrea, Heyne, Henrike, Rodosthenous, Rodos, Palotie, Tuula, Palin, Kimmo, Garcia-Tabuenca, Javier, Siirtola, Harri, Kristiansson, Kati, Ritari, Jarmo, Pylkäs, Katri, Karjalainen, Minna, Mantere, Tuomo, Siltanen, Sanna, Kuopio, Teijo, Kajanne, Risto, Aavikko, Mervi, Cooper, Helen, Palin, Henna, Dada, Oluwaseun Alexander, Donner, Kati, Kaiharju, Essi, Lähteenmäki, Sini, Toivola, Auli, Paajanen, Teemu, Niemi, Marianna, Donner, Kati

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L2 The expanded cag repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the R6/2 and Q175 HD mouse brain von González-Barriga, Anchel, Kourkouta, Eleni, Kontkanen, Outi, Heikkinen, Taneli, Lehtimäki, Kimmo, Deutekom, Judith CT van, Datson, Nicole A

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Inaugural Charles River World Congress on Animal Models in Drug Discovery and Development von Berzofsky, Jay A, Koch, Lauren Gerard, Britton, Steven L, Chen, Shaochen, Zhu, Wei, Ma, Xuanyi, Comuzzie, Anthony G, Devy-Dimanche, Laetitia, Feaver, Ryan, Grimm, Jan, Hock, Christoph, Nitsch, Roger M, Hoying, James B, Lusis, Aldons J, Marincola, Francesco, Samayoa, Josue, Turan, Tolga, Pearce, David A, Nurmi, Antti, Huhtala, Tuulia, Shatillo, Artem, Puoliväli, Jukka, Heikkinen, Taneli, Bragge, Timo, Lehtimäki, Kimmo, Sanyal, Arun J, Strange, Kevin, Taylor, D. Lansing, Miedel, Mark, Jia, Shanhang, Soto-Guterriez, Alex, Stern, Andrew, Gough, Albert

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Effects of Ovariectomy and Estrogen Treatment on Learning and Hippocampal Neurotransmitters in Mice von Heikkinen, Taneli, Puoliväli, Jukka, Liu, Li, Rissanen, Anna, Tanila, Heikki

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B25 Mitochondrial fission and fusion in skeletal muscle from HD patients and zQ175 mice von Kojer, Kerstin, Hering, Tanja, Birth, Nathalie, Lenk, Thomas, Hallitsch, Jaqueline, Parker, Jennifer, Haider, Salman, Heikkinen, Taneli, Kontkanen, Outi, Tabrizi, Sarah J, Taanman, Jan-Willem, Orth, Michael

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mNos2 Deletion and Human NOS2 Replacement in Alzheimer Disease Models von Colton, Carol A, Wilson, Joan G, Everhart, Angela, Wilcock, Donna M, Puoliväli, Jukka, Heikkinen, Taneli, Oksman, Juho, Jääskeläinen, Olli, Lehtimäki, Kimmo, Laitinen, Teemu, Vartiainen, Nina, Vitek, Michael P

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