Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease von Heikkinen, Taneli, Lehtimäki, Kimmo, Vartiainen, Nina, Puoliväli, Jukka, Hendricks, Susan J, Glaser, Jack R, Bradaia, Amyaouch, Wadel, Kristian, Touller, Chrystelle, Kontkanen, Outi, Yrjänheikki, Juha M, Buisson, Bruno, Howland, David, Beaumont, Vahri, Munoz-Sanjuan, Ignacio, Park, Larry C

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Rapid and robust patterns of spontaneous locomotor deficits in mouse models of Huntington's disease von Heikkinen, Taneli, Bragge, Timo, Bhattarai, Niina, Parkkari, Teija, Puolivali, Jukka, Kontkanen, Outi, Sweeney, Patrick, Park, Larry C., Munoz-Sanjuan, Ignacio

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Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington’s Disease von Liu, Longbin, Malagu, Karine, Haughan, Alan F., Khetarpal, Vinod, Stott, Andrew J., Esmieu, William, Vater, Huw D., Webster, Stephen J., Van de Poël, Amanda J., Clissold, Cole, Cosgrove, Brett, Sutton, Benjamin, Spencer, Jonathan A., Breccia, Perla, Gancia, Emanuela, Bonomo, Silvia, Ladduwahetty, Tammy, Lazari, Ovadia, Patel, Hiral, Atton, Helen C., Clifton, Steve, Mota, Daniel M., Magnani, Dario, O’Neill, Amy, Stebbeds, Marta, Macabuag, Natsuko, Todd, Daniel, Herva, Maria E., Mitchell, Philip, Visser, Mijke, Compte Sancerni, Sara, Grand Moursel, Laure, da Silva, Marta, Kritikou, Eva, Heikkinen, Taneli T., Bolkvadze, Tamuna, Fodale, Valentina, Spadafora, Debora, Daldin, Manuel, Bresciani, Alberto, Mangette, John E., Doherty, Elizabeth M., Lee, Matthew R., Herbst, Todd, Monteagudo, Edith, Macdonald, Douglas, Plotnikov, Nikolay V., Chambers, Mark, McAllister, George, Muňoz-Sanjuan, Ignacio, Dominguez, Celia

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Global Rhes knockout in the Q175 Huntington's disease mouse model von Heikkinen, Taneli, Bragge, Timo, Kuosmanen, Juha, Parkkari, Teija, Gustafsson, Sanna, Kwan, Mei, Beltran, Jose, Ghavami, Afshin, Subramaniam, Srinivasa, Shahani, Neelam, Ramirez-Jarquin, Uri Nimrod, Park, Larry, Munoz-Sanjuan, Ignacio, Marchionini, Deanna M.

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The expanded CAG repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the HD mouse brain von Datson, Nicole A, González-Barriga, Anchel, Kourkouta, Eleni, Weij, Rudie, van de Giessen, Jeroen, Mulders, Susan, Kontkanen, Outi, Heikkinen, Taneli, Lehtimäki, Kimmo, van Deutekom, Judith C T

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Vertigoheel promotes rodent cognitive performance in multiple memory tests von Ott, Kerstin, Heikkinen, Taneli, Lehtimäki, Kimmo K, Paldanius, Kaisa, Puoliväli, Jukka, Pussinen, Raimo, Andriambeloson, Emile, Huyard, Bertrand, Wagner, Stéphanie, Schnack, Cathrin, Wahler, Anke, von Einem, Bjoern, von Arnim, Christine A F, Burmeister, Yvonne, Weyer, Kathrin, Seilheimer, Bernd

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Evidences for Mutant Huntingtin Inducing Musculoskeletal and Brain Growth Impairments via Disturbing Testosterone Biosynthesis in Male Huntington Disease Animals von Yu-Taeger, Libo, Novati, Arianna, Weber, Jonasz Jeremiasz, Singer-Mikosch, Elisabeth, Pabst, Ann-Sophie, Cheng, Fubo, Saft, Carsten, Koenig, Jennifer, Ellrichmann, Gisa, Heikkinen, Taneli, Pouladi, Mahmoud A, Riess, Olaf, Nguyen, Huu Phuc

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Impaired Performance of the Q175 Mouse Model of Huntington's Disease in the Touch Screen Paired Associates Learning Task von Piiponniemi, Tuukka O, Parkkari, Teija, Heikkinen, Taneli, Puoliväli, Jukka, Park, Larry C, Cachope, Roger, Kopanitsa, Maksym V

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Inaugural Charles River World Congress on Animal Models in Drug Discovery and Development von Berzofsky, Jay A, Koch, Lauren Gerard, Britton, Steven L, Chen, Shaochen, Zhu, Wei, Ma, Xuanyi, Comuzzie, Anthony G, Devy-Dimanche, Laetitia, Feaver, Ryan, Grimm, Jan, Hock, Christoph, Nitsch, Roger M, Hoying, James B, Lusis, Aldons J, Marincola, Francesco, Samayoa, Josue, Turan, Tolga, Pearce, David A, Nurmi, Antti, Huhtala, Tuulia, Shatillo, Artem, Puoliväli, Jukka, Heikkinen, Taneli, Bragge, Timo, Lehtimäki, Kimmo, Sanyal, Arun J, Strange, Kevin, Taylor, D. Lansing, Miedel, Mark, Jia, Shanhang, Soto-Guterriez, Alex, Stern, Andrew, Gough, Albert

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Hippocampal Aβ42 Levels Correlate with Spatial Memory Deficit in APP and PS1 Double Transgenic Mice von Puoliväli, Jukka, Wang, Jun, Heikkinen, Taneli, Heikkilä, Matti, Tapiola, Tero, van Groen, Thomas, Tanila, Heikki

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Effects of Ovariectomy and Estrogen Treatment on Learning and Hippocampal Neurotransmitters in Mice von Heikkinen, Taneli, Puoliväli, Jukka, Liu, Li, Rissanen, Anna, Tanila, Heikki

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Physiological and behavioural implications of the portosystemic shunt in C57Bl/6J mice von Lehtimäki, Kimmo K., Rytkönen, Jussi, Pussinen, Raimo, Shatillo, Artem, Bragge, Timo, Heikkinen, Taneli, Fischer, David F., Kopanitsa, Maksym V., Sweeney, Patrick, Nurmi, Antti, Puoliväli, Jukka

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Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease von Zeitler, Bryan, Froelich, Steven, Marlen, Kimberly, Shivak, David A, Yu, Qi, Li, Davis, Pearl, Jocelynn R, Miller, Jeffrey C, Zhang, Lei, Paschon, David E, Hinkley, Sarah J, Ankoudinova, Irina, Lam, Stephen, Guschin, Dmitry, Kopan, Lexi, Cherone, Jennifer M, Nguyen, Hoang-Oanh B, Qiao, Guijuan, Ataei, Yasaman, Mendel, Matthew C, Amora, Rainier, Surosky, Richard, Laganiere, Josee, Vu, B Joseph, Narayanan, Anand, Sedaghat, Yalda, Tillack, Karsten, Thiede, Christina, Gärtner, Annette, Kwak, Seung, Bard, Jonathan, Mrzljak, Ladislav, Park, Larry, Heikkinen, Taneli, Lehtimäki, Kimmo K, Svedberg, Marie M, Häggkvist, Jenny, Tari, Lenke, Tóth, Miklós, Varrone, Andrea, Halldin, Christer, Kudwa, Andrea E, Ramboz, Sylvie, Day, Michelle, Kondapalli, Jyothisri, Surmeier, D James, Urnov, Fyodor D, Gregory, Philip D, Rebar, Edward J, Muñoz-Sanjuán, Ignacio, Zhang, H Steve

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Characterization of behavioral changes, MRI brain volumetry and brain metabolic profile of 5xFAD mouse model of Alzheimer’s disease von Heikkinen, Taneli, Karhunen, Petri, Stenius, Taina‐Kaisa, Kosunen, Henni, Lehtimäki, Kimmo, Shatillo, Artem, Oksman, Juho, Dudek, Mateusz, Miszczuk, Diana

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Effects of fimbria-fornix lesion and amyloid pathology on spatial learning and memory in transgenic APP+PS1 mice von Liu, Li, Ikonen, Sami, Heikkinen, Taneli, Heikkilä, Matti, Puoliväli, Jukka, van Groen, Thomas, Tanila, Heikki

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Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington’s Disease Models von Beaumont, Vahri, Zhong, Sheng, Lin, Hai, Xu, WenJin, Bradaia, Amyaouch, Steidl, Esther, Gleyzes, Melanie, Wadel, Kristian, Buisson, Bruno, Padovan-Neto, Fernando E., Chakroborty, Shreaya, Ward, Karen M., Harms, John F., Beltran, Jose, Kwan, Mei, Ghavami, Afshin, Häggkvist, Jenny, Tóth, Miklós, Halldin, Christer, Varrone, Andrea, Schaab, Christoph, Dybowski, J. Nikolaj, Elschenbroich, Sarah, Lehtimäki, Kimmo, Heikkinen, Taneli, Park, Larry, Rosinski, James, Mrzljak, Ladislav, Lavery, Daniel, West, Anthony R., Schmidt, Christopher J., Zaleska, Margaret M., Munoz-Sanjuan, Ignacio

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The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease von Beaumont, Vahri, Mrzljak, Ladislav, Dijkman, Ulrike, Freije, Robert, Heins, Mariette, Rassoulpour, Arash, Tombaugh, Geoffrey, Gelman, Simon, Bradaia, Amyaouch, Steidl, Esther, Gleyzes, Melanie, Heikkinen, Taneli, Lehtimäki, Kimmo, Puoliväli, Jukka, Kontkanen, Outi, Javier, Robyn M., Neagoe, Ioana, Deisemann, Heike, Winkler, Dirk, Ebneth, Andreas, Khetarpal, Vinod, Toledo-Sherman, Leticia, Dominguez, Celia, Park, Larry C., Munoz-Sanjuan, Ignacio

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L2 The expanded cag repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the R6/2 and Q175 HD mouse brain von González-Barriga, Anchel, Kourkouta, Eleni, Kontkanen, Outi, Heikkinen, Taneli, Lehtimäki, Kimmo, Deutekom, Judith CT van, Datson, Nicole A

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B25 Mitochondrial fission and fusion in skeletal muscle from HD patients and zQ175 mice von Kojer, Kerstin, Hering, Tanja, Birth, Nathalie, Lenk, Thomas, Hallitsch, Jaqueline, Parker, Jennifer, Haider, Salman, Heikkinen, Taneli, Kontkanen, Outi, Tabrizi, Sarah J, Taanman, Jan-Willem, Orth, Michael

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mNos2 Deletion and Human NOS2 Replacement in Alzheimer Disease Models von Colton, Carol A, Wilson, Joan G, Everhart, Angela, Wilcock, Donna M, Puoliväli, Jukka, Heikkinen, Taneli, Oksman, Juho, Jääskeläinen, Olli, Lehtimäki, Kimmo, Laitinen, Teemu, Vartiainen, Nina, Vitek, Michael P

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