Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer von Huang, Peter Q, Boren, Brant C, Hegde, Sayee G, Liu, Hui, Unni, Aditya K, Abraham, Sunny, Hopkins, Chad D, Paliwal, Sunil, Samatar, Ahmed A, Li, Jiali, Bunker, Kevin D

Volltext

Abstract 2606: ZN-c3, a potent and selective Wee-1 inhibitor demonstrates anti-tumor activities in combination with other targeted therapies and overcomes PARP inhibitor resistance von Li, Jiali, Ma, Jianhui, de Jong, Petrus R., Izadi, Hooman, Hoang, Tiffany, Ibrahim, Noah, Boren, Brant, Hegde, Sayee Hegde, Doñate, Fernando, Samatar, Ahmed A.

Volltext

Structure-based optimization of aminothiadiazole inhibitors of AKT von Mortensen, Deborah S., Hegde, Sayee G., Perrin-Ninkovic, Sophie M., Bahmanyar, Sogole, McCarrick, Meg, Harris, Roy, Hilgraf, Robert, Lee, Branden G. S., McKie, Jeff, Nadolny, Lisa, Sapienza, John, Collette, Alice, Cox, Sarah, Gamez, James C., Hensel, Jennifer L., Hua, Xuequn Helen, Leisten, Jim, Raymon, Heather K., Tran, Tam, Narla, Rama Krishna

Volltext

Microtubule-Stabilizing Agents Based on Designed Laulimalide Analogues von Mooberry, Susan L., Randall-Hlubek, Deborah A., Leal, Rachel M., Hegde, Sayee G., Hubbard, Robert D., Zhang, Lei, Wender, Paul A.

Volltext

Total Synthesis of (−)-Laulimalide von Wender, Paul A, Hegde, Sayee G, Hubbard, Robert D, Zhang, Lei

Volltext

Synthesis and Biological Evaluation of (−)-Laulimalide Analogues von Wender, Paul A, Hegde, Sayee G, Hubbard, Robert D, Zhang, Lei, Mooberry, Susan L

Volltext

Abstract 4373: Discovery of ZN-c5, a novel potent and oral selective estrogen receptor degrader von Samatar, Ahmed A., Li, Jiali, Hegde, Sayee, Huang, Peter, Ma, Jianhui, Bunker, Kevin, Winkler, Robert, Donate, Fernando, Sergeeva, Masha

Volltext

Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005 von Papa, Patrick, Whitefield, Brandon, Mortensen, Deborah S, Cashion, Dan, Huang, Dehua, Torres, Eduardo, Parnes, Jason, Sapienza, John, Hansen, Joshua, Correa, Matthew, Delgado, Mercedes, Harris, Roy, Hegde, Sayee, Norris, Stephen, Bahmanyar, Sogole, Plantevin-Krenitsky, Veronique, Liu, Zheng, Leftheris, Katerina, Kulkarni, Ashutosh, Bennett, Brydon, Hur, Eun Mi, Ringheim, Garth, Khambatta, Godrej, Chan, Henry, Muir, Jeffrey, Blease, Kate, Burnett, Kelven, LeBrun, Laurie, Morrison, Lisa, Celeridad, Maria, Khattri, Roli, Cathers, Brian E

Volltext

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor von Plantevin Krenitsky, Véronique, Nadolny, Lisa, Delgado, Mercedes, Ayala, Leticia, Clareen, Steven S., Hilgraf, Robert, Albers, Ronald, Hegde, Sayee, D’Sidocky, Neil, Sapienza, John, Wright, Jonathan, McCarrick, Meg, Bahmanyar, Sogole, Chamberlain, Philip, Delker, Silvia L., Muir, Jeff, Giegel, David, Xu, Li, Celeridad, Maria, Lachowitzer, Jeff, Bennett, Brydon, Moghaddam, Mehran, Khatsenko, Oleg, Katz, Jason, Fan, Rachel, Bai, April, Tang, Yang, Shirley, Michael A., Benish, Brent, Bodine, Tracey, Blease, Kate, Raymon, Heather, Cathers, Brian E., Satoh, Yoshitaka

Volltext

Correction to "Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005" von Papa, Patrick, Whitefield, Brandon, Mortensen, Deborah S, Cashion, Dan, Huang, Dehua, Torres, Eduardo, Parnes, Jason, Sapienza, John, Hansen, Joshua, Correa, Matthew, Delgado, Mercedes, Harris, Roy, Hegde, Sayee, Norris, Stephen, Bahmanyar, Sogole, Plantevin-Krenitsky, Veronique, Liu, Zheng, Leftheris, Katerina, Kulkarni, Ashutosh, Bennett, Brydon, Hur, Eun Mi, Ringheim, Garth, Khambatta, Godrej, Chan, Henry, Muir, Jeffrey, Blease, Kate, Burnett, Kelven, LeBrun, Laurie, Morrison, Lisa, Celeridad, Maria, Khattri, Roli, Cathers, Brian E

Volltext

ESTROGEN RECEPTOR MODULATORS von BUNKER, Kevin, Duane, HUANG, Peter, Qinhua, HEGDE, Sayee, Gajanan, ZHANG, Guobao

Volltext bestellen

Estrogen receptor modulators von Hegde, Sayee Gajanan, Bunker, Kevin Duane, Zhang, Guobao, Huang, Peter Qinhua

Volltext bestellen

ESTROGEN RECEPTOR MODULATORS von HEGDE, Sayee, BUNKER, Kevin, HUANG, Peter, ZHANG, Guobao

Volltext bestellen

SALTS AND FORMS OF AN ESTROGEN RECEPTOR MODULATOR von SLEE, Deborah, Helen, BUNKER, Kevin, Duane, KNIGHT, John, HUANG, Peter, Qinhua, HEGDE, Sayee, Gajanan

Volltext bestellen

ESTROGEN RECEPTOR MODULATORS von BUNKER, Kevin, Duane, HUANG, Peter, Qinhua, HEGDE, Sayee, Gajanan, ZHANG, Guobao

Volltext bestellen

Substituted 1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones von Liu, Hui, Abraham, Sunny, Paliwal, Sunil, Bunker, Kevin Duane, Unni, Aditya, Hegde, Sayee, Boren, Brant, Hopkins, Chad, Huang, Peter Qinhua

Volltext bestellen

SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES von Liu, Hui, Abraham, Sunny, Paliwal, Sunil, Hegde, Sayee Gajanan, Bunker, Kevin Duane, Unni, Aditya Krishnan, Hopkins, Chad Daniel, Boren, Brant Clayton, Huang, Peter Qinhua

Volltext bestellen

SALTS AND FORMS OF AN ESTROGEN RECEPTOR MODULATOR von SLEE, Deborah, HEGDE, Sayee, KNIGHT, John, BUNKER, Kevin, HUANG, Peter

Volltext bestellen

ESTROGEN RECEPTOR MODULATORS von SLEE, Deborah, Helen, PINCHMAN, Joseph, Robert, BUNKER, Kevin, Duane, HUANG, Peter, Qinhua, HEGDE, Sayee, Gajanan, SIT, Rakesh, Kumar, HOPKINS, Chad, Daniel

Volltext bestellen

ESTROGEN RECEPTOR MODULATORS von SLEE, Deborah, Helen, PINCHMAN, Joseph, Robert, BUNKER, Kevin, Duane, HUANG, Peter, Qinhua, HEGDE, Sayee, Gajanan, SIT, Rakesh, Kumar, HOPKINS, Chad, Daniel

Volltext bestellen