High-Throughput, Accurate Mass Metabolome Profiling of Cellular Extracts by Flow Injection–Time-of-Flight Mass Spectrometry von Fuhrer, Tobias, Heer, Dominik, Begemann, Boris, Zamboni, Nicola

Volltext

Identification of furfural as a key toxin in lignocellulosic hydrolysates and evolution of a tolerant yeast strain von Heer, Dominik, Sauer, Uwe

Volltext

Resistance of Saccharomyces cerevisiae to High Concentrations of Furfural Is Based on NADPH-Dependent Reduction by at Least Two Oxireductases von Heer, Dominik, Heine, Daniel, Sauer, Uwe

Volltext

A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature von Kemble, Alicia M, Hornsperger, Benoit, Ruf, Iris, Richter, Hans, Benz, Jörg, Kuhn, Bernd, Heer, Dominik, Wittwer, Matthias, Engelhardt, Britta, Grether, Uwe, Collin, Ludovic

Volltext

Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct von Gehrlein, Alexandra, Udayar, Vinod, Anastasi, Nadia, Morella, Martino L., Ruf, Iris, Brugger, Doris, von der Mark, Sophia, Thoma, Ralf, Rufer, Arne, Heer, Dominik, Pfahler, Nina, Jochner, Anton, Niewoehner, Jens, Wolf, Luise, Fueth, Matthias, Ebeling, Martin, Villaseñor, Roberto, Zhu, Yanping, Deen, Matthew C., Shan, Xiaoyang, Ehsaei, Zahra, Taylor, Verdon, Sidransky, Ellen, Vocadlo, David J., Freskgård, Per-Ola, Jagasia, Ravi

Volltext

Physiological and Molecular Characterization of Yeast Cultures Pre-Adapted for Fermentation of Lignocellulosic Hydrolysate von Almeida, João R. M., Wiman, Magnus, Heer, Dominik, Brink, Daniel P., Sauer, Uwe, Hahn-Hägerdal, Bärbel, Lidén, Gunnar, Gorwa-Grauslund, Marie F.

Volltext

Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging von He, Yingfang, Schild, Matthias, Grether, Uwe, Benz, Jörg, Leibrock, Lea, Heer, Dominik, Topp, Andreas, Collin, Ludovic, Kuhn, Bernd, Wittwer, Matthias, Keller, Claudia, Gobbi, Luca C, Schibli, Roger, Mu, Linjing

Volltext

Dynamic metabolomics differentiates between carbon and energy starvation in recombinant Saccharomyces cerevisiae fermenting xylose von Bergdahl, Basti, Heer, Dominik, Sauer, Uwe, Hahn-Hägerdal, Bärbel, van Niel, Ed WJ

Volltext

Identification of ( R )-[ 18 F]YH134 for Monoacylglycerol Lipase Neuroimaging and Exploration of Its Use for Central Nervous System and Peripheral Drug Development von He, Yingfang, Krämer, Stefanie D, Grether, Uwe, Wittwer, Matthias B, Collin, Ludovic, Kuhn, Bernd, Topp, Andreas, Heer, Dominik, O'Hara, Fionn, Honer, Michael, Pavlovic, Anto, Richter, Hans, Ritter, Martin, Rombach, Didier, Keller, Claudia, Gobbi, Luca, Mu, Linjing

Volltext

6 β -Hydroxycortisol Is an Endogenous Probe for Evaluation of Drug–Drug Interactions Involving a Multispecific Renal Organic Anion Transporter, OAT3/ SLC22A8 , in Healthy Subjects... von Imamura, Yuichiro, Tsuruya, Yuri, Damme, Katja, Heer, Dominik, Kumagai, Yuji, Maeda, Kazuya, Murayama, Nobuyuki, Okudaira, Noriko, Kurihara, Atsushi, Izumi, Takashi, Sugiyama, Yuichi, Kusuhara, Hiroyuki

Volltext

Preclinical Evaluation of the Reversible Monoacylglycerol Lipase PET Tracer (R)‐[11C]YH132: Application in Drug Development and Neurodegenerative Diseases von He, Yingfang, Delparente, Aro, Jie, Caitlin V. M. L, Keller, Claudia, Humm, Roland, Heer, Dominik, Collin, Ludovic, Schibli, Roger, Gobbi, Luca, Grether, Uwe, Mu, Linjing

Volltext

Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization von Butini, Stefania, Grether, Uwe, Jung, Kwang-Mook, Ligresti, Alessia, Allarà, Marco, Postmus, Annemarieke G. J., Maramai, Samuele, Brogi, Simone, Papa, Alessandro, Carullo, Gabriele, Sykes, David, Veprintsev, Dmitry, Federico, Stefano, Grillo, Alessandro, Di Guglielmo, Bruno, Ramunno, Anna, Stevens, Anna Floor, Heer, Dominik, Lamponi, Stefania, Gemma, Sandra, Benz, Jörg, Di Marzo, Vincenzo, van der Stelt, Mario, Piomelli, Daniele, Campiani, Giuseppe

Volltext

6β-Hydroxycortisol is an endogenous probe for evaluation of drug-drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in healthy subjects von Imamura, Yuichiro, Tsuruya, Yuri, Damme, Katja, Heer, Dominik, Kumagai, Yuji, Maeda, Kazuya, Murayama, Nobuyuki, Okudaira, Noriko, Kurihara, Atsushi, Izumi, Takashi, Sugiyama, Yuichi, Kusuhara, Hiroyuki

Volltext

Structure-Guided Discovery of cis-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors von Kuhn, Bernd, Ritter, Martin, Hornsperger, Benoit, Bell, Charles, Kocer, Buelent, Rombach, Didier, Lutz, Marius D. R., Gobbi, Luca, Kuratli, Martin, Bartelmus, Christian, Bürkler, Markus, Koller, Raffael, Tosatti, Paolo, Ruf, Iris, Guerard, Melanie, Pavlovic, Anto, Stephanus, Juliane, O’Hara, Fionn, Wetzl, Dennis, Saal, Wiebke, Stihle, Martine, Roth, Doris, Hug, Melanie, Huber, Sylwia, Heer, Dominik, Kroll, Carsten, Topp, Andreas, Schneider, Manfred, Gertsch, Jürg, Glasmacher, Sandra, van der Stelt, Mario, Martella, Andrea, Wittwer, Matthias Beat, Collin, Ludovic, Benz, Jörg, Richter, Hans, Grether, Uwe

Volltext

Discovery of Orally Available and Brain Penetrant AEP Inhibitors von Krummenacher, Daniela, He, Weiping, Kuhn, Bernd, Schnider, Christian, Beurier, Angélica, Brom, Virginie, Sivasothy, Thulase, Marty, Christine, Tosstorff, Andreas, Hewings, David S., Mesch, Stefanie, Pinard, Emmanuel, Brändlin, Mathis, Hochstrasser, Remo, Westwood, Paul, Rothe, Judith, Kronenberger, Alexandra, Morandi, Federica, Gutbier, Simon, Schuler, Angelika, Heer, Dominik, Gloria, Ludivine Esteves, Joedicke, Lisa, Rudolph, Markus G., Müller, Lutz, Grüninger, Fiona, Baumann, Karlheinz, Kaniyappan, Senthilvelrajan, Manevski, Nenad, Bartels, Björn

Volltext

Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain von He, Yingfang, Grether, Uwe, Taddio, Marco F., Meier, Carla, Keller, Claudia, Edelmann, Martin R., Honer, Michael, Huber, Sylwia, Wittwer, Matthias B., Heer, Dominik, Richter, Hans, Collin, Ludovic, Hug, Melanie N., Hilbert, Manuel, Postmus, Annemarieke G.J., Stevens, Anna Floor, van der Stelt, Mario, Krämer, Stefanie D., Schibli, Roger, Mu, Linjing, Gobbi, Luca C.

Volltext

Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold von He, Yingfang, Gobbi, Luca C., Herde, Adrienne Müller, Rombach, Didier, Ritter, Martin, Kuhn, Bernd, Wittwer, Matthias B., Heer, Dominik, Hornsperger, Benoit, Bell, Charles, O'Hara, Fionn, Benz, Jörg, Honer, Michael, Keller, Claudia, Collin, Ludovic, Richter, Hans, Schibli, Roger, Grether, Uwe, Mu, Linjing

Volltext

Amphotericin B as a Potential Probe of the Physical State of Vesicle Membranes von Zumbuehl, Andreas, Stano, Pasquale, Heer, Dominik, Walde, Peter, Carreira, Erick M

Volltext

NOUVEAUX COMPOSÉS HÉTÉROCYCLIQUES UTILISÉS EN TANT QU'INHIBITEURS DE MONOACYLGLYCÉROL LIPASE von HORNSPERGER, Benoit, ANSELM, Lilli, KROLL, Carsten, RICHTER, Hans, BENZ, Joerg, GROEBKE ZBINDEN, Katrin, GRETHER, Uwe, O`HARA, Fionn, HEER, Dominik, KUHN, Bernd

Volltext bestellen

NEW HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS von HORNSPERGER, Benoit, ANSELM, Lilli, KROLL, Carsten, RICHTER, Hans, BENZ, Joerg, GROEBKE ZBINDEN, Katrin, GRETHER, Uwe, O`HARA, Fionn, HEER, Dominik, KUHN, Bernd

Volltext bestellen