Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis von Jackstadt, Rene, van Hooff, Sander R., Leach, Joshua D., Cortes-Lavaud, Xabier, Lohuis, Jeroen O., Ridgway, Rachel A., Wouters, Valérie M., Roper, Jatin, Kendall, Timothy J., Roxburgh, Campbell S., Horgan, Paul G., Nixon, Colin, Nourse, Craig, Gunzer, Matthias, Clark, William, Hedley, Ann, Yilmaz, Omer H., Rashid, Mamunur, Bailey, Peter, Biankin, Andrew V., Campbell, Andrew D., Adams, David J., Barry, Simon T., Steele, Colin W., Medema, Jan Paul, Sansom, Owen J.

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NOTUM from Apc-mutant cells biases clonal competition to initiate cancer von Flanagan, Dustin J., Pentinmikko, Nalle, Luopajärvi, Kalle, Willis, Nicky J., Gilroy, Kathryn, Raven, Alexander P., Mcgarry, Lynn, Englund, Johanna I., Webb, Anna T., Scharaw, Sandra, Nasreddin, Nadia, Hodder, Michael C., Ridgway, Rachel A., Minnee, Emma, Sphyris, Nathalie, Gilchrist, Ella, Najumudeen, Arafath K., Romagnolo, Beatrice, Perret, Christine, Williams, Ann C., Clevers, Hans, Nummela, Pirjo, Lähde, Marianne, Alitalo, Kari, Hietakangas, Ville, Hedley, Ann, Clark, William, Nixon, Colin, Kirschner, Kristina, Jones, E. Yvonne, Ristimäki, Ari, Leedham, Simon J., Fish, Paul V., Vincent, Jean-Paul, Katajisto, Pekka, Sansom, Owen J.

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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function von Sakamaki, Jun-ichi, Wilkinson, Simon, Hahn, Marcel, Tasdemir, Nilgun, O’Prey, Jim, Clark, William, Hedley, Ann, Nixon, Colin, Long, Jaclyn S., New, Maria, Van Acker, Tim, Tooze, Sharon A., Lowe, Scott W., Dikic, Ivan, Ryan, Kevin M.

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Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells von Carruthers, Ross D, Ahmed, Shafiq U, Ramachandran, Shaliny, Strathdee, Karen, Kurian, Kathreena M, Hedley, Ann, Gomez-Roman, Natividad, Kalna, Gabriela, Neilson, Mathew, Gilmour, Lesley, Stevenson, Katrina H, Hammond, Ester M, Chalmers, Anthony J

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Fumarate induces redox-dependent senescence by modifying glutathione metabolism von Zheng, Liang, Cardaci, Simone, Jerby, Livnat, MacKenzie, Elaine D., Sciacovelli, Marco, Johnson, T. Isaac, Gaude, Edoardo, King, Ayala, Leach, Joshua D. G., Edrada-Ebel, RuAngelie, Hedley, Ann, Morrice, Nicholas A., Kalna, Gabriela, Blyth, Karen, Ruppin, Eytan, Frezza, Christian, Gottlieb, Eyal

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PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer von Galbraith, Laura C. A., Mui, Ernest, Nixon, Colin, Hedley, Ann, Strachan, David, MacKay, Gillian, Sumpton, David, Sansom, Owen J., Leung, Hing Y., Ahmad, Imran

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Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma von Muthalagu, Nathiya, Monteverde, Tiziana, Raffo-Iraolagoitia, Ximena, Wiesheu, Robert, Whyte, Declan, Hedley, Ann, Laing, Sarah, Kruspig, Bjorn, Upstill-Goddard, Rosanna, Shaw, Robin, Neidler, Sarah, Rink, Curtis, Karim, Saadia A., Gyuraszova, Katarina, Nixon, Colin, Clark, William, Biankin, Andrew, Carlin, Leo M., Coffelt, Seth B., Sansom, Owen J., Morton, Jennifer P., Murphy, Daniel J.

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Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer von Gay, David M., Ridgway, Rachel A., Müller, Miryam, Hodder, Michael C., Hedley, Ann, Clark, William, Leach, Joshua D., Jackstadt, Rene, Nixon, Colin, Huels, David J., Campbell, Andrew D., Bird, Thomas G., Sansom, Owen J.

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MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer von Casciano, Jessica C., Perry, Caroline, Cohen-Nowak, Adam J., Miller, Katelyn D., Vande Voorde, Johan, Zhang, Qifeng, Chalmers, Susan, Sandison, Mairi E., Liu, Qin, Hedley, Ann, McBryan, Tony, Tang, Hsin-Yao, Gorman, Nicole, Beer, Thomas, Speicher, David W., Adams, Peter D., Liu, Xuefeng, Schlegel, Richard, McCarron, John G., Wakelam, Michael J. O., Gottlieb, Eyal, Kossenkov, Andrew V., Schug, Zachary T.

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Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion von Marco, Sergi, Neilson, Matthew, Moore, Madeleine, Perez-Garcia, Arantxa, Hall, Holly, Mitchell, Louise, Lilla, Sergio, Blanco, Giovani R., Hedley, Ann, Zanivan, Sara, Norman, Jim C.

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Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging von Freckmann, Eva C., Sandilands, Emma, Cumming, Erin, Neilson, Matthew, Román-Fernández, Alvaro, Nikolatou, Konstantina, Nacke, Marisa, Lannagan, Tamsin R. M., Hedley, Ann, Strachan, David, Salji, Mark, Morton, Jennifer P., McGarry, Lynn, Leung, Hing Y., Sansom, Owen J., Miller, Crispin J., Bryant, David M.

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SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer von Martinez, Rafael S., Salji, Mark J., Rushworth, Linda, Ntala, Chara, Blanco, Giovanny Rodriguez, Hedley, Ann, Clark, William, Peixoto, Paul, Hervouet, Eric, Renaude, Elodie, Kung, Sonia H. Y., Galbraith, Laura C. A., Nixon, Colin, Lilla, Sergio, Mackay, Gillian M., Fazli, Ladan, Gaughan, Luke, Sumpton, David, Gleave, Martin E., Zanivan, Sara, Blomme, Arnaud, Leung, Hing Y.

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Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress von Port, Jennifer, Muthalagu, Nathiya, Raja, Meera, Ceteci, Fatih, Monteverde, Tiziana, Kruspig, Björn, Hedley, Ann, Kalna, Gabriela, Lilla, Sergio, Neilson, Lisa, Brucoli, Martina, Gyuraszova, Katarina, Tait-Mulder, Jacqueline, Mezna, Mokdad, Svambaryte, Silvija, Bryson, Amy, Sumpton, David, McVie, Allan, Nixon, Colin, Drysdale, Martin, Esumi, Hiroyasu, Murray, Graeme I, Sansom, Owen J, Zanivan, Sara R, Murphy, Daniel J

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Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix von Kay, Emily J., Paterson, Karla, Riera-Domingo, Carla, Sumpton, David, Däbritz, J. Henry M., Tardito, Saverio, Boldrini, Claudia, Hernandez-Fernaud, Juan R., Athineos, Dimitris, Dhayade, Sandeep, Stepanova, Ekaterina, Gjerga, Enio, Neilson, Lisa J., Lilla, Sergio, Hedley, Ann, Koulouras, Grigorios, McGregor, Grace, Jamieson, Craig, Johnson, Radia Marie, Park, Morag, Kirschner, Kristina, Miller, Crispin, Kamphorst, Jurre J., Loayza-Puch, Fabricio, Saez-Rodriguez, Julio, Mazzone, Massimiliano, Blyth, Karen, Zagnoni, Michele, Zanivan, Sara

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Transcriptome profiling of developmental and xenobiotic responses in a keystone soil animal, the oligochaete annelid Lumbricus rubellus von Owen, Jennifer, Hedley, B Ann, Svendsen, Claus, Wren, Jodie, Jonker, Martijs J, Hankard, Peter K, Lister, Linsey J, Stürzenbaum, Stephen R, Morgan, A John, Spurgeon, David J, Blaxter, Mark L, Kille, Peter

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Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features von Flanagan, Dustin J., Amirkhah, Raheleh, Vincent, David F., Gunduz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J., McCorry, Amy M. B., Fisher, Natalie C., Davis, Hayley L., Ridgway, Rachel A., Lohuis, Jeroen, Leach, Joshua D. G., Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K., Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L., Kerr, Emma M., Longley, Daniel B., Ginty, Fiona, Cho, Sanghee, Coleman, Helen G., Loughrey, Maurice B., Bardelli, Alberto, Maughan, Timothy S., Campbell, Andrew D., Lawler, Mark, Leedham, Simon J., Barry, Simon T., Inman, Gareth J., van Rheenen, Jacco, Dunne, Philip D., Sansom, Owen J.

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BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration von Loveridge, Carolyn J., Slater, Sarah, Campbell, Kirsteen J., Nam, Noor A., Knight, John, Ahmad, Imran, Hedley, Ann, Lilla, Sergio, Repiscak, Peter, Patel, Rachana, Salji, Mark, Fleming, Janis, Mitchell, Louise, Nixon, Colin, Strathdee, Douglas, Neilson, Matthew, Ntala, Chara, Bryson, Sheila, Zanivan, Sara, Edwards, Joanne, Robson, Craig N., Goodyear, Carl S., Blyth, Karen, Leung, Hing Y.

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Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features von Flanagan, Dustin J., Amirkhah, Raheleh, Vincent, David F., Gunduz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J., McCorry, Amy M. B., Fisher, Natalie C., Davis, Hayley L., Ridgway, Rachel A., Lohuis, Jeroen, Leach, Joshua D. G., Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K., Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L., Kerr, Emma M., Longley, Daniel B., Ginty, Fiona, Cho, Sanghee, Coleman, Helen G., Loughrey, Maurice B., Bardelli, Alberto, Maughan, Timothy S., Campbell, Andrew D., Lawler, Mark, Leedham, Simon J., Barry, Simon T., Inman, Gareth J., van Rheenen, Jacco, Dunne, Philip D., Sansom, Owen J.

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Mesenchymal stromal cells cultured in physiological conditions sustain citrate secretion with glutamate anaplerosis von Taurino, Giuseppe, Deshmukh, Ruhi, Villar, Victor H., Chiu, Martina, Shaw, Robin, Hedley, Ann, Shokry, Engy, Sumpton, David, Dander, Erica, D'Amico, Giovanna, Bussolati, Ovidio, Tardito, Saverio

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Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1 von Patel, Rachana, Fleming, Janis, Mui, Ernest, Loveridge, Carolyn, Repiscak, Peter, Blomme, Arnaud, Harle, Victoria, Salji, Mark, Ahmad, Imran, Teo, Katy, Hamdy, Freddie C, Hedley, Ann, van den Broek, Niels, Mackay, Gillian, Edwards, Joanne, Sansom, Owen J, Leung, Hing Y

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