Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications von Heckman, Pim R. A., van Duinen, Marlies A., Bollen, Eva P. P., Nishi, Akinori, Wennogle, Lawrence P., Blokland, Arjan, Prickaerts, Jos

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Acute administration of roflumilast enhances sensory gating in healthy young humans in a randomized trial von Heckman, Pim R. A., Van Duinen, Marlies A., Blokland, Arjan, Uz, Tolga, Prickaerts, Jos, Sambeth, Anke

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Phosphodiesterase 4 inhibition affects both the direct and indirect pathway: an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulata von Heckman, P. R. A., Schweimer, J. V., Sharp, T., Prickaerts, J., Blokland, A.

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Role of cyclic nucleotides and their downstream signaling cascades in memory function: Being at the right time at the right spot von Argyrousi, Elentina K., Heckman, Pim R.A., Prickaerts, Jos

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Pro-cognitive effect of upregulating cyclic guanosine monophosphate signalling during memory acquisition or early consolidation is mediated by increased AMPA receptor trafficking von Argyrousi, Elentina K, Heckman, Pim RA, van Hagen, Britt TJ, Muysers, Hannah, van Goethem, Nick P, Prickaerts, Jos

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The contribution of Parkin, PINK1 and DJ‐1 genes to selective neuronal degeneration in Parkinson's disease von van der Vlag, Marc, Havekes, Robbert, Heckman, Pim R. A.

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Treatment with the selective PDE4B inhibitor A-33 or PDE4D inhibitor zatolmilast prevents sleep deprivation-induced deficits in spatial pattern separation von Zhao, Hongyu, Blokland, Arjan, Prickaerts, Jos, Havekes, Robbert, Heckman, Pim R A

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Acute sleep loss impairs object but not spatial pattern separation in humans von Blokland, Arjan, Jackson, Meyra, Puustinen, Kia, Soeterboek, Jens, Heckman, Pim R.A.

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Phosphodiesterase inhibition and modulation of corticostriatal and hippocampal circuits: Clinical overview and translational considerations von Heckman, P.R.A., Blokland, A., Bollen, E.P.P., Prickaerts, J.

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Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study von Blokland, Arjan, Van Duinen, Marlies A., Sambeth, Anke, Heckman, Pim R.A., Tsai, Max, Lahu, Gezim, Uz, Tolga, Prickaerts, Jos

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Sleep deprivation‐induced impairment of memory consolidation is not mediated by glucocorticoid stress hormones von Raven, Frank, Heckman, Pim R. A., Havekes, Robbert, Meerlo, Peter

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Genetic manipulation of cyclic nucleotide signaling during hippocampal neuroplasticity and memory formation von Kelly, Michy P., Heckman, Pim R.A., Havekes, Robbert

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Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults von Van Duinen, M.A., Sambeth, A., Heckman, P.R.A., Smit, S., Tsai, M., Lahu, G., Uz, T., Blokland, A., Prickaerts, J.

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Recovering object-location memories after sleep deprivation-induced amnesia von Bolsius, Youri G., Heckman, Pim R.A., Paraciani, Camilla, Wilhelm, Sophia, Raven, Frank, Meijer, Elroy L., Kas, Martien J.H., Ramirez, Steve, Meerlo, Peter, Havekes, Robbert

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Alzheimer's disease pathogenesis: The role of disturbed sleep in attenuated brain plasticity and neurodegenerative processes von Havekes, Robbert, Heckman, Pim R.A., Wams, Emma J., Stasiukonyte, Neringa, Meerlo, Peter, Eisel, Ulrich L.M.

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PDE and cognitive processing: Beyond the memory domain von Heckman, P.R.A., Blokland, A., Ramaekers, J., Prickaerts, J.

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Soluble guanylate cyclase stimulator riociguat improves spatial memory in mice via peripheral mechanisms von Nelissen, Ellis, van Hagen, Britt T.J., Argyrousi, Elentina K., van Goethem, Nick P., Heckman, Pim R.A., Paes, Dean, Mulder-Jongen, Danielle A.J., Ramaekers, Johannes G., Blokland, Arjan, Schmidt, Harald H.H.W., Prickaerts, Jos

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Phosphodiesterase inhibitors roflumilast and vardenafil prevent sleep deprivation‐induced deficits in spatial pattern separation von Heckman, Pim R. A., Roig Kuhn, Femke, Raven, Frank, Bolsius, Youri G., Prickaerts, Jos, Meerlo, Peter, Havekes, Robbert

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Validation of the xylazine/ketamine anesthesia test as a predictor of the emetic potential of pharmacological compounds in rats von Nelissen, Ellis, van Goethem, Nick P., Bonassoli, Vivian T., Heckman, Pim R.A., van Hagen, Britt T.J., Suay, Dila, Wouters, Caroline, Prickaerts, Jos

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The mediating role of phosphodiesterase type 4 in the dopaminergic modulation of motor impulsivity von Heckman, P.R.A., Blokland, A., Van Goethem, N.P., Van Hagen, B.T.J., Prickaerts, J.

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