Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk von Mirams, Gary R., Cui, Yi, Sher, Anna, Fink, Martin, Cooper, Jonathan, Heath, Bronagh M., McMahon, Nick C., Gavaghan, David J., Noble, Denis

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Localisation and functional significance of ryanodine receptors during β-adrenoceptor stimulation in the guinea-pig sino-atrial node von Rigg, Lauren, Heath, Bronagh M, Cui, Yi, Terrar, Derek A

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The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing... von Skidmore, John, Atcha, Zeenat, Boucherat, Emmanuelle, Castelletti, Laura, Chen, Deborah W., Coppo, Frank T., Cutler, Leanne, Dunsdon, Rachel M., Heath, Bronagh M., Hutchings, Rio, Hurst, David N., Javed, Sahar, Martin, Samuel, Maskell, Emma S.L., Norton, David, Pemberton, Darrel J., Redshaw, Sally, Rutter, Richard, Sehmi, Sanjeet S., Scoccitti, Tiziana, Temple, Hannah E., Theobald, Pam, Ward, Robert W., Wilson, David M.

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Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition von Skidmore, John, Atcha, Zeenat, Boucherat, Emmanuelle, Castelletti, Laura, Chen, Deborah W., Coppo, Frank T., Cutler, Leanne, Dunsdon, Rachel M., Heath, Bronagh M., Hutchings, Rio, Hurst, David N., Javed, Sahar, Martin, Samuel, Maskell, Emma S.L., Norton, David, Pemberton, Darrel J., Redshaw, Sally, Rutter, Richard, Sehmi, Sanjeet S., Scoccitti, Tiziana, Temple, Hannah E., Theobald, Pam, Ward, Robert W., Wilson, David M.

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Modulation of the hyperpolarization-activated current (If) by calcium and calmodulin in the guinea-pig sino-atrial node von RIGG, Lauren, MATTICK, Paul A. D, HEATH, Bronagh M, TERRAR, Derek A

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Use of the dog isolated cardiac Purkinje fibre assay to investigate a compound with in vivo proarrhythmic activity von Graham, Sara G., Wilson, Carol M., Cui, Yi, Heath, Bronagh M.

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The discovery of 2-fluoro-N-3-fluoro-4-5-((4-morpholinobutyl)amino)-1,3, 4-oxadiazol-2-ylphenylbenzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing eff... von SKIDMORE, John, ATCHA, Zeenat, HURST, David N, JAVED, Sahar, MARTIN, Samuel, MASKELL, Emma S. L, NORTON, David, PEMBERTON, Darrel J, REDSHAW, Sally, RUTTER, Richard, SEHMI, Sanjeet S, SCOCCITTI, Tiziana, BOUCHERAT, Emmanuelle, TEMPLE, Hannah E, THEOBALD, Pam, WARD, Robert W, WILSON, David M, CASTELLETTI, Laura, CHEN, Deborah W, COPPO, Frank T, CUTLER, Leanne, DUNSDON, Rachel M, HEATH, Bronagh M, HUTCHINGS, Rio

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Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics von Vargas, Hugo M., Bass, Alan S., Breidenbach, Alexander, Feldman, Hal S., Gintant, Gary A., Harmer, Alexander R., Heath, Bronagh, Hoffmann, Peter, Lagrutta, Armando, Leishman, Derek, McMahon, Nick, Mittelstadt, Scott, Polonchuk, Liudmila, Pugsley, Michael K., Salata, Joseph J., Valentin, Jean-Pierre

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WITHDRAWN: Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics von Vargas, Hugo M., Bass, Alan S., Breidenbach, Alexander, Feldman, Hal S., Gintant, Gary A., Harmer, Alexander, Heath, Bronagh, Hoffmann, Peter, Lagrutta, Armando, Leishmann, Derek, McMahon, Nick, Mittelstadt, Scott, Polonchuk, Liudmila, Pugsley, Michael K., Salata, Joseph J., Valentin, Jean-Pierre

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