Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro- N 2-(2-isopropoxy-5-methyl-... von Marsilje, Thomas H., Pei, Wei, Chen, Bei, Lu, Wenshuo, Uno, Tetsuo, Jin, Yunho, Jiang, Tao, Kim, Sungjoon, Li, Nanxin, Warmuth, Markus, Sarkisova, Yelena, Sun, Frank, Steffy, Auzon, Pferdekamper, AnneMarie C., Li, Allen G., Joseph, Sean B., Kim, Young, Liu, Bo, Tuntland, Tove, Cui, Xiaoming, Gray, Nathanael S., Steensma, Ruo, Wan, Yongqin, Jiang, Jiqing, Chopiuk, Greg, Li, Jie, Gordon, W. Perry, Richmond, Wendy, Johnson, Kevin, Chang, Jonathan, Groessl, Todd, He, You-Qun, Phimister, Andrew, Aycinena, Alex, Lee, Christian C., Bursulaya, Badry, Karanewsky, Donald S., Seidel, H. Martin, Harris, Jennifer L., Michellys, Pierre-Yves

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Midazolam Oxidation by Cytochrome P450 3A4 and Active-Site Mutants: an Evaluation of Multiple Binding Sites and of the Metabolic Pathway That Leads to Enzyme Inactivation von Khan, Kishore K, He, You Qun, Domanski, Tammy L, Halpert, James R

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Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5‑Chloro‑N2‑(2-isopropoxy-5-methyl-4-... von Marsilje, Thomas H, Pei, Wei, Chen, Bei, Lu, Wenshuo, Uno, Tetsuo, Jin, Yunho, Jiang, Tao, Kim, Sungjoon, Li, Nanxin, Warmuth, Markus, Sarkisova, Yelena, Sun, Frank, Steffy, Auzon, Pferdekamper, AnneMarie C, Li, Allen G, Joseph, Sean B, Kim, Young, Liu, Bo, Tuntland, Tove, Cui, Xiaoming, Gray, Nathanael S, Steensma, Ruo, Wan, Yongqin, Jiang, Jiqing, Chopiuk, Greg, Li, Jie, Gordon, W. Perry, Richmond, Wendy, Johnson, Kevin, Chang, Jonathan, Groessl, Todd, He, You-Qun, Phimister, Andrew, Aycinena, Alex, Lee, Christian C, Bursulaya, Badry, Karanewsky, Donald S, Seidel, H. Martin, Harris, Jennifer L, Michellys, Pierre-Yves

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Dual ALK and CDK4/6 Inhibition Demonstrates Synergy against Neuroblastoma von Wood, Andrew C, Krytska, Kateryna, Ryles, Hannah T, Infarinato, Nicole R, Sano, Renata, Hansel, Theodore D, Hart, Lori S, King, Frederick J, Smith, Timothy R, Ainscow, Edward, Grandinetti, Kathryn B, Tuntland, Tove, Kim, Sunkyu, Caponigro, Giordano, He, You Qun, Krupa, Shiva, Li, Nanxin, Harris, Jennifer L, Mossé, Yaël P

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A modern in vivo pharmacokinetic paradigm: combining snapshot, rapid and full PK approaches to optimize and expedite early drug discovery von Li, Chun, Liu, Bo, Chang, Jonathan, Groessl, Todd, Zimmerman, Matthew, He, You-Qun, Isbell, John, Tuntland, Tove

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Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix von Scott, Emily E, Liu, Hong, Qun He, You, Li, Weihua, Halpert, James R

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Amino Acid Residues Critical for Differential Inhibition of CYP2B4, CYP2B5, and CYP2B1 by Phenylimidazoles von Spatzenegger, M, Wang, Q, He, Y Q, Wester, M R, Johnson, E F, Halpert, J R

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Site-Directed Mutagenesis of Cytochrome P450eryF:  Implications for Substrate Oxidation, Cooperativity, and Topology of the Active Site von Khan, Kishore K, He, You Ai, He, You Qun, Halpert, James R

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The Role of Cytochrome 2B1 Substrate Recognition Site Residues 115, 294, 297, 298, and 362 in the Oxidation of Steroids and 7-Alkoxycoumarins von Domanski, Tammy L., He, You-Qun, Scott, Emily E., Wang, Qinmi, Halpert, James R.

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Escherichia coli Expression of Site-Directed Mutants of Cytochrome P450 2B1 from Six Substrate Recognition Sites: Substrate Specificity and Inhibitor Selectivity Studies von He, You Qun, He, You Ai, Halpert, James R

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Identification of Three Key Residues in Substrate Recognition Site 5 of Human Cytochrome P450 3A4 by Cassette and Site-Directed Mutagenesis von He, You Ai, He, You Qun, Szklarz, Grazyna D, Halpert, James R

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Abstract 1000: Combination CDK4/6 and ALK inhibition demonstrates on-target synergy against neuroblastoma von Wood, Andrew C., Krytska, Kateryna, Ryles, Hannah, Sano, Renata, Li, Nanxin, King, Frederick, Smith, Timothy, Tuntland, Tove, Kim, Sunkyu, Caponigro, Giordano, He, You Qun, Jennifer, Harris, Mosse, Yael

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Abstract B42: Combinatorial CDK4/6 and ALK inhibition demonstrates on-target synergy against neuroblastoma von Wood, Andrew C., Krytska, Kateryna, Ryles, Hannah, Sano, Renata, Hansel, Theodore, Li, Nanxin, King, Frederick, Smith, Timothy, Tuntland, Tove, Kim, Sunkyu, Caponigro, Giordano, He, You-Qun, Harris, Jennifer, Mosse, Yael

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The genetic determinants of the CYP3A5 polymorphism von HUSTERT, Elisabeth, HABERL, Michael, KOCH, Ina, ZIBAT, Arne, BROCKMÖLLER, Jürgen, HALPERT, James R, ZANGER, Ulrich M, WOJNOWSKI, Leszek, BURK, Oliver, WOLBOLD, Renzo, HE, You-Qun, KLEIN, Kathrin, NUESSLER, Andreas C, NEUHAUS, Peter, KLATTIG, Jürgen, EISELT, Regina

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An Electrostatically Driven Conformational Transition Is Involved in the Mechanisms of Substrate Binding and Cooperativity in Cytochrome P450eryF von Davydov, Dmitri R, Botchkareva, Alexandra E, Kumar, Santosh, He, You Qun, Halpert, James R

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Effect of diacutaneous fibrolysis on the muscular properties of gastrocnemius muscle von Lopez-de-Celis, Carlos, Perez-Bellmunt, Albert, Bueno-Gracia, Elena, Fanlo-Mazas, Pablo, Zarate-Tejero, Carlos Antonio, Llurda-Almuzara, Luis, Cadellans Arroniz, Aida, Rodriguez-Rubio, Pere Ramon

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A geochemical characterization of lead ores in China: An isotope database for provenancing archaeological materials von Hsu, Yiu-Kang, Sabatini, Benjamin J

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Tongxinluo attenuates reperfusion injury in diabetic hearts by angiopoietin-like 4-mediated protection of endothelial barrier integrity via PPAR-α pathway von Qi, Kang, Li, Xiangdong, Geng, Yongjian, Cui, Hehe, Jin, Chen, Wang, Peihe, Li, Yue, Yang, Yuejin

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Applied Mathematics and Machine Learning

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Effect of acute exposure to moderate altitude on kinematic variables of the ippon-seoi-nage and its relationship with the countermovement jump in elite judokas von Almeida, Filipa, Bonitch-Góngora, Juan, Padial, Paulino, de la Fuente, Blanca, Morales-Artacho, Antonio J, Feriche, Belén

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