Emerging Therapies and Novel Targets for TDP-43 Proteinopathy in ALS/FTD von Hayes, Lindsey R., Kalab, Petr

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C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation von Cheng, Weiwei, Wang, Shaopeng, Mestre, Alexander A., Fu, Chenglai, Makarem, Andres, Xian, Fengfan, Hayes, Lindsey R., Lopez-Gonzalez, Rodrigo, Drenner, Kevin, Jiang, Jie, Cleveland, Don W., Sun, Shuying

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C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import von Hayes, Lindsey R., Duan, Lauren, Bowen, Kelly, Kalab, Petr, Rothstein, Jeffrey D.

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RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention von Dos Passos, Patricia M, Hemamali, Erandika H, Mamede, Lohany D, Hayes, Lindsey R, Ayala, Yuna M

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CRISPR-Cas13d targeting suppresses repeat-associated non-AUG translation of C9orf72 hexanucleotide repeat RNA von Liu, Honghe, Zhao, Xiao-Feng, Lu, Yu-Ning, Hayes, Lindsey R, Wang, Jiou

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CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation von Cheng, Weiwei, Wang, Shaopeng, Zhang, Zhe, Morgens, David W., Hayes, Lindsey R., Lee, Soojin, Portz, Bede, Xie, Yongzhi, Nguyen, Baotram V., Haney, Michael S., Yan, Shirui, Dong, Daoyuan, Coyne, Alyssa N., Yang, Junhua, Xian, Fengfan, Cleveland, Don W., Qiu, Zhaozhu, Rothstein, Jeffrey D., Shorter, James, Gao, Fen-Biao, Bassik, Michael C., Sun, Shuying

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A Helicase Unwinds Hexanucleotide Repeat RNA G‑Quadruplexes and Facilitates Repeat-Associated Non-AUG Translation von Liu, Honghe, Lu, Yu-Ning, Paul, Tapas, Periz, Goran, Banco, Michael T, Ferré-D’Amaré, Adrian R, Rothstein, Jeffrey D, Hayes, Lindsey R, Myong, Sua, Wang, Jiou

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DDX3X overexpression decreases dipeptide repeat proteins in a mouse model of C9ORF72-ALS/FTD von Fu, Xiujuan, Zhang, Zhe, Hayes, Lindsey R., Wright, Noelle, Asbury, Julie, Li, Shelley, Ye, Yingzhi, Sun, Shuying

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C9ORF72-ALS/FTD: Transgenic Mice Make a Come-BAC von Hayes, Lindsey R., Rothstein, Jeffrey D.

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Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD von Wang, Shaopeng, Latallo, Malgorzata J., Zhang, Zhe, Huang, Bo, Bobrovnikov, Dmitriy G., Dong, Daoyuan, Livingston, Nathan M., Tjoeng, Wilson, Hayes, Lindsey R., Rothstein, Jeffrey D., Ostrow, Lyle W., Wu, Bin, Sun, Shuying

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Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export von Duan, Lauren, Zaepfel, Benjamin L., Aksenova, Vasilisa, Dasso, Mary, Rothstein, Jeffrey D., Kalab, Petr, Hayes, Lindsey R.

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Dancing muscles: the value of real-time ultrasound evaluation of muscle in myositis and mimics von Albayda, Jemima, Hayes, Lindsey R., Christopher-Stine, Lisa

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G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD von Coyne, Alyssa N., Zaepfel, Benjamin L., Hayes, Lindsey, Fitchman, Boris, Salzberg, Yuval, Luo, En-Ching, Bowen, Kelly, Trost, Hannah, Aigner, Stefan, Rigo, Frank, Yeo, Gene W., Harel, Amnon, Svendsen, Clive N., Sareen, Dhruv, Rothstein, Jeffrey D.

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Order from chaos: Using CSF proteomics to predict ALS progression von Yang, Xiuli, Hayes, Lindsey R.

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UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction von Zaepfel, Benjamin L., Zhang, Zhe, Maulding, Kirstin, Coyne, Alyssa N., Cheng, Weiwei, Hayes, Lindsey R., Lloyd, Thomas E., Sun, Shuying, Rothstein, Jeffrey D.

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Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model von Nguyen, Lien, Montrasio, Fabio, Pattamatta, Amrutha, Tusi, Solaleh Khoramian, Bardhi, Olgert, Meyer, Kevin D., Hayes, Lindsey, Nakamura, Katsuya, Banez-Coronel, Monica, Coyne, Alyssa, Guo, Shu, Laboissonniere, Lauren A., Gu, Yuanzheng, Narayanan, Saravanakumar, Smith, Benjamin, Nitsch, Roger M., Kankel, Mark W., Rushe, Mia, Rothstein, Jeffrey, Zu, Tao, Grimm, Jan, Ranum, Laura P.W.

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Axonal degeneration in the peripheral nervous system: Implications for the pathogenesis of amyotrophic lateral sclerosis von Fischer-Hayes, Lindsey R., Brotherton, Terrell, Glass, Jonathan D.

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Distal denervation in the SOD1 knockout mouse correlates with loss of mitochondria at the motor nerve terminal von Hayes, Lindsey R., Asress, Seneshaw A., Li, Yingjie, Galkin, Alexander, Stepanova, Anna, Kawamata, Hibiki, Manfredi, Giovanni, Glass, Jonathan D.

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Elevated nuclear TDP-43 induces constitutive exon skipping von Carmen-Orozco, Rogger P, Tsao, William, Ye, Yingzhi, Sinha, Irika R, Chang, Koping, Trinh, Vickie T, Chung, William, Bowden, Kyra, Troncoso, Juan C, Blackshaw, Seth, Hayes, Lindsey R, Sun, Shuying, Wong, Philip C, Ling, Jonathan P

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Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes von Zhang, Xi, Das, Tanuza, Chao, Tiffany F., Trinh, Vickie, Carmen-Orozco, Rogger P., Ling, Jonathan P., Kalab, Petr, Hayes, Lindsey R.

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