Molecular responses in decitabine- and decitabine/ venetoclax-treated patients with acute myeloid leukemia and myelodysplastic syndromes von Gruszczynska, Agata, Maiti, Abhishek, Miller, Christopher A, Ramakrishnan, Sai Mukund, Link, Daniel C, Uy, Geoffrey L, Petti, Allegra A, Hayes, Kala, DiNardo, Courtney D, Ravandi, Farhad, Ley, Timothy J, Spencer, David H, Gao, Feng, Konopleva, Marina Y, Welch, John S

Volltext

Abstract 2371: MicroRNA-99b-5p targets the mTOR/AR axis and induced autophagic cell death in prostate cancer cells von Niture, Suryakant, Tricoli, Lucas, Hayes, Kala, Kumar, Deepak

Volltext

MicroRNA-99b-5p targets mTOR/AR axis, induces autophagy and inhibits prostate cancer cell proliferation von Niture, Suryakant, Tricoli, Lucas, Qi, Qi, Gadi, Sashi, Hayes, Kala, Kumar, Deepak

Volltext

Biomarkers of Clinical Resistance to Decitabine and Venetoclax Therapy Inferred By Transcriptome and Methylation Analyses von Yamatani, Kotoko, Maiti, Abhishek, Watanabe, Tatsuro, Saito, Kaori, Hayes, Kala, Kinjo, Sonoko, Ikeo, Kazuho, Miida, Takashi, Kimura, Shinya, DiNardo, Courtney D., Su, Xiaoping, Tabe, Yoko, Konopleva, Marina

Volltext

PPARG and ASS1: Targets of Metabolic Alteration in Venetoclax / Decitabine Resistant Acute Myeloid Leukemia von Yamatani, Kotoko, Watanabe, Tatsuro, Saito, Kaori, Maiti, Abhishek, Yamashita, Satoshi, Khasawneh, Abdullah, Paran, Faith Jessica, Hayes, Kala, Borthakur, Gautam, Harman, Joe R, Kimura, Shinya, DiNardo, Courtney D., Milne, Thomas A, Andreeff, Michael, Tabe, Yoko, Konopleva, Marina Y.

Volltext

Molecular Profiling of Response and Resistance to Venetoclax-Decitabine Therapy in Acute Myeloid Leukemia von Khasawneh, Abdullah, Paran, Faith Jessica, Oyama, Rieko, Maiti, Abhishek, Abbas, Hussein A, Wang, Bofei, Desai, Poonam N, Hayes, Kala, Harman, Joe R, Su, Xiaoping, DiNardo, Courtney D., Andreeff, Michael, Milne, Thomas A, Konopleva, Marina Y., Tabe, Yoko

Volltext

Triple combination targeting methyltransferase, BCL‐2, and PD‐1 facilitates antileukemia responses in acute myeloid leukemia von Zeng, Zhihong, Maiti, Abhishek, Herbrich, Shelley, Cai, Tianyu, Cavazos, Antonio, Manzella, Taylor, Ma, Helen, Hayes, Kala, Matthews, Jairo, DiNardo, Courtney D., Daver, Naval G., Konopleva, Marina Y.

Volltext

“Triple” Combination of Targeting Methyltransferase, BCL-2 and PD-1 Facilitates Therapeutic Responses in Acute Myeloid Leukemia (AML) von Zeng, Zhihong, Herbrich, Shelley, Cai, Tianyu, Cavazos, Antonio, Manzella, Taylor, Ma, Helen, Kuruvilla, Vinitha Mary, Hayes, Kala, Matthews, Jairo A., DiNardo, Courtney D., Daver, Naval, Konopleva, Marina

Volltext

Single-Cell Proteogenomics Analysis of AML Samples Treated with Decitabine and Venetoclax Reveals Divergent Treatment Escape Mechanisms von Kim, Yi June, Li, Zongrui, Maiti, Abhishek, Tanaka, Tomoyuki, Uryu, Hidetaka, Furudate, Ken, Hayes, Kala, Daver, Naval, Pemmaraju, Naveen, Kadia, Tapan M., Ravandi, Farhad, Short, Nicholas J., Ohanian, Maro, Borthakur, Gautam, Jain, Nitin, Issa, Ghayas C., Masarova, Lucia, Kornblau, Steven M., Wierda, William G., Loghavi, Sanam, Wang, Sa A., Garcia-Manero, Guillermo, Kantarjian, Hagop, DiNardo, Courtney D., Konopleva, Marina Y., Takahashi, Koichi

Volltext

Accumulation of Intracellular L-Lactate and Irreversible Disruption of Mitochondrial Membrane Potential upon Dual Inhibition of Oxphos and Lactate Transporter MCT-1 Induce Syntheti... von Baran, Natalia, Patel, Shraddha, Lodi, Alessia, Ortiz, Jose Enriquez, Dhungana, Yogesh, Collins, Meghan, Skwarska, Anna, Weng, Connie, Ramage, Cassandra L, Hayes, Kala, Zeng, Zhihong, Davis, Eric, Alatrash, Gheath, Marszalek, Joseph R, Yu, Jiyang, Bhattacharya, Pratip K, Tiziani, Stefano, Konopleva, Marina

Volltext

Lipophagy As a Mechanism of Resistance in T-ALL Following Energetic Crisis Induced By Oxphos/MCT1 Blockade: Strategies to Eradicate Residual Disease von Baran, Natalia, Patel, Shraddha, Ramage, Cassandra L, Lodi, Alessia, Ortiz, Jose Enriquez, Dhungana, Yogesh, Collins, Meghan, Skwarska, Anna, Weng, Connie, Hayes, Kala, Zeng, Zhihong, Cooper, Laurie, Davis, Richard Eric, Alatrash, Gheath, Marszalek, Joseph R, Yu, Jiyang, Bhattacharya, Pratip K, Tiziani, Stefano, Konopleva, Marina

Volltext

Transanal Total Mesorectal Excision: International Registry Results of the First 720 Cases von Penna, Marta, Hompes, Roel, Arnold, Steve, Wynn, Greg, Austin, Ralph, Warusavitarne, Janindra, Moran, Brendan, Hanna, George B, Mortensen, Neil J, Tekkis, Paris P

Volltext

Racialized Economic Segregation and Breast Cancer Mortality among Women in Maryland von Connor, Avonne E, Kaur, Maneet, Dibble, Kate E, Visvanathan, Kala, Dean, Lorraine T, Hayes, Jennifer H

Volltext

Incidence and Risk Factors for Anastomotic Failure in 1594 Patients Treated by Transanal Total Mesorectal Excision: Results From the International TaTME Registry von Penna, Marta, Hompes, Roel, Arnold, Steve, Wynn, Greg, Austin, Ralph, Warusavitarne, Janindra, Moran, Brendan, Hanna, George B., Mortensen, Neil J., Tekkis, Paris P.

Volltext

Discovery of common and rare genetic risk variants for colorectal cancer von Huyghe, Jeroen R., Chen, Sai, Schmit, Stephanie L., Conti, David V., Qu, Conghui, Edlund, Christopher K., Schumacher, Fredrick R., Levine, David M., Nelson, Sarah C., Sinnott-Armstrong, Nasa A., Albanes, Demetrius, Anderson, Kristin, Arnau-Collell, Coral, Banbury, Barbara L., Berndt, Sonja I., Boeing, Heiner, Buch, Stephan, Buchanan, Daniel D., Burnett-Hartman, Andrea, Butterbach, Katja, Campbell, Peter T., Carlson, Christopher S., Castellví-Bel, Sergi, Chan, Andrew T., Connolly, Charles M., Cross, Amanda J., de la Chapelle, Albert, Duggan, David, Easton, Douglas F., English, Dallas R., Feskens, Edith J. M., Forman, David, Gallinger, Steven, Gauderman, W. James, Giles, Graham G., Gong, Jian, Grove, John S., Haile, Robert W., Hampe, Jochen, Hampel, Heather, Harlid, Sophia, Hayes, Richard B., Hoffmeister, Michael, Hsu, Wan-Ling, Huang, Wen-Yi, Hunter, David J., Ibañez-Sanz, Gemma, Jenkins, Mark A., Joshi, Amit D., Joshu, Corinne E., Key, Timothy J., Kolonel, Laurence N., Küry, Sébastien, Kweon, Sun-Seog, Le Marchand, Loic, Lejbkowicz, Flavio, Li, Li, Lieb, Wolfgang, Lin, Yi, Ling, Hua, Louie, Tin L., Männistö, Satu, Martín, Vicente, Masala, Giovanna, McNeil, Caroline E., Melas, Marilena, Murphy, Neil, Myte, Robin, Newcomb, Polly A., Onland-Moret, N. Charlotte, Pearlman, Rachel, Pinchev, Mila, Pugh, Elizabeth, Raskin, Leon, Rodríguez-Barranco, Miguel, Sakoda, Lori C., Schoen, Robert E., Seminara, Daniela, Shah, Mitul, Shulman, Katerina, Stadler, Zsofia K., Thibodeau, Stephen N., Thomas, Sushma S., Toland, Amanda E., Trichopoulou, Antonia, Van Den Berg, David J., van Duijnhoven, Franzel J. B., Van Guelpen, Bethany, Vijai, Joseph, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Weigl, Korbinian, Weinstein, Stephanie J., Zaidi, Syed H., Zheng, Wei, Scacheri, Peter C., Casey, Graham, Hsu, Li

Volltext

Lasmiditan is an effective acute treatment for migraine: A phase 3 randomized study von Kuca, Bernice, Silberstein, Stephen D, Wietecha, Linda, Berg, Paul H, Dozier, Gregory, Lipton, Richard B

Volltext

Genetic architectures of proximal and distal colorectal cancer are partly distinct von Huyghe, Jeroen R, Figueiredo, Jane C, Schmit, Stephanie L, Conti, David V, Barfield, Richard, Cross, Amanda J, Duggan, David, Harlid, Sophia, Imaz, Liher, Kang, Hyun Min, Perduca, Vittorio, Perez-Cornago, Aurora, Schumacher, Fredrick R, Slattery, Martha L, Toland, Amanda E, van Duijnhoven, Fränzel J B, Van Guelpen, Bethany, Agudo, Antonio, Albanes, Demetrius, Alonso, M Henar, Arnau-Collell, Coral, Arndt, Volker, Banbury, Barbara L, Bassik, Michael C, Bézieau, Stéphane, Bishop, D Timothy, Boehm, Juergen, Boeing, Heiner, Boutron-Ruault, Marie-Christine, Brenner, Hermann, Brezina, Stefanie, Buch, Stephan, Buchanan, Daniel D, Burnett-Hartman, Andrea, Caan, Bette J, Castells, Antoni, Chan, Andrew T, Chang-Claude, Jenny, Chanock, Stephen J, Curtis, Keith R, English, Dallas R, Feskens, Edith J M, Gala, Manish, Gauderman, W James, Giles, Graham G, Grady, William M, Grove, John S, Gsur, Andrea, Gunter, Marc J, Haile, Robert W, Hampe, Jochen, Hopper, John L, Hsu, Wan-Ling, Hudson, Thomas J, Jenab, Mazda, Joshi, Amit D, Keku, Temitope O, Kooperberg, Charles, Kühn, Tilman, Le Marchand, Loic, Lejbkowicz, Flavio, Li, Christopher I, Li, Li, Lieb, Wolfgang, Lindblom, Annika, Markowitz, Sanford D, Moreno, Lorena, Murphy, Neil, Nassir, Rami, Offit, Kenneth, Ogino, Shuji, Panico, Salvatore, Parfrey, Patrick S, Pearlman, Rachel, Pharoah, Paul D P, Potter, John D, Prentice, Ross L, Raskin, Leon, Rennert, Hedy S, Schoen, Robert E, Tangen, Catherine M, Thibodeau, Stephen N, Thomas, Duncan C, Trichopoulou, Antonia, Ulrich, Cornelia M, Visvanathan, Kala, Vodicka, Pavel, Vymetalkova, Veronika, Weinstein, Stephanie J, White, Emily, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Nickerson, Deborah A, Scacheri, Peter C, Kundaje, Anshul, Casey, Graham, Gruber, Stephen B, Moreno, Victor, Peters, Ulrike

Volltext

Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk von Thomas, Minta, Sakoda, Lori C., Hoffmeister, Michael, Rosenthal, Elisabeth A., Lee, Jeffrey K., van Duijnhoven, Franzel J.B., Platz, Elizabeth A., Wu, Anna H., Dampier, Christopher H., de la Chapelle, Albert, Wolk, Alicja, Joshi, Amit D., Burnett-Hartman, Andrea, Gsur, Andrea, Lindblom, Annika, Castells, Antoni, Win, Aung Ko, Namjou, Bahram, Van Guelpen, Bethany, Tangen, Catherine M., He, Qianchuan, Li, Christopher I., Schafmayer, Clemens, Joshu, Corinne E., Ulrich, Cornelia M., Bishop, D. Timothy, Buchanan, Daniel D., Schaid, Daniel, Drew, David A., Muller, David C., Duggan, David, Crosslin, David R., Albanes, Demetrius, Giovannucci, Edward L., Larson, Eric, Qu, Flora, Mentch, Frank, Giles, Graham G., Hakonarson, Hakon, Hampel, Heather, Stanaway, Ian B., Figueiredo, Jane C., Huyghe, Jeroen R., Minnier, Jessica, Chang-Claude, Jenny, Hampe, Jochen, Harley, John B., Visvanathan, Kala, Curtis, Keith R., Offit, Kenneth, Li, Li, Le Marchand, Loic, Vodickova, Ludmila, Gunter, Marc J., Jenkins, Mark A., Slattery, Martha L., Lemire, Mathieu, Woods, Michael O., Song, Mingyang, Murphy, Neil, Lindor, Noralane M., Dikilitas, Ozan, Pharoah, Paul D.P., Campbell, Peter T., Newcomb, Polly A., Milne, Roger L., MacInnis, Robert J., Castellví-Bel, Sergi, Ogino, Shuji, Berndt, Sonja I., Bézieau, Stéphane, Thibodeau, Stephen N., Gallinger, Steven J., Zaidi, Syed H., Harrison, Tabitha A., Keku, Temitope O., Hudson, Thomas J., Vymetalkova, Veronika, Moreno, Victor, Martín, Vicente, Arndt, Volker, Wei, Wei-Qi, Chung, Wendy, Su, Yu-Ru, Hayes, Richard B., White, Emily, Vodicka, Pavel, Casey, Graham, Gruber, Stephen B., Schoen, Robert E., Chan, Andrew T., Potter, John D., Brenner, Hermann, Jarvik, Gail P., Corley, Douglas A., Peters, Ulrike, Hsu, Li

Volltext

Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations von Thomas, Minta, Su, Yu-Ru, Sakoda, Lori C., Schmit, Stephanie L., Timofeeva, Maria N., Chen, Zhishan, Fernandez-Rozadilla, Ceres, Law, Philip J., Murphy, Neil, Carreras-Torres, Robert, van Duijnhoven, Franzel J. B., Shin, Aesun, Wolk, Alicja, Phipps, Amanda I., Zauber, Ann G., Wu, Anna H., Um, Caroline Y., Tangen, Catherine M., Gignoux, Chris, Newton, Christina, Haiman, Christopher A., Qu, Conghui, Bishop, D. Timothy, Buchanan, Daniel D., Crosslin, David R., Kim, Dong-Hyun, Hauser, Elizabeth, White, Emily, Siegel, Erin, Rennert, Gad, Giles, Graham G., Hampel, Heather, Brenner, Hermann, Oze, Isao, Lee, Jeffrey K., Kim, Jeongseon, Huyghe, Jeroen R., Zheng, Jiayin, Hampe, Jochen, Greenson, Joel, Palmer, Julie R., Visvanathan, Kala, Matsuo, Keitaro, Jung, Keum Ji, Li, Li, Le Marchand, Loic, Vodickova, Ludmila, Bujanda, Luis, Matejcic, Marco, Jenkins, Mark A., Slattery, Martha L., D’Amato, Mauro, Hoffmeister, Michael, Woods, Michael O., Kim, Michelle, Song, Mingyang, Iwasaki, Motoki, Du, Mulong, Sawada, Norie, Vodicka, Pavel, Campbell, Peter T., Pearlman, Rachel, Pai, Rish K., Prentice, Ross L., Küry, Sébastien, Castellví-Bel, Sergi, Berndt, Sonja I., Lee, Soo Chin, Brezina, Stefanie, Weinstein, Stephanie J., Chanock, Stephen J., Jee, Sun Ha, Kweon, Sun-Seog, Vadaparampil, Susan, Harrison, Tabitha A., Yamaji, Taiki, Keku, Temitope O., Vymetalkova, Veronika, Arndt, Volker, Jia, Wei-Hua, Shu, Xiao-Ou, Lin, Yi, Ahn, Yoon-Ok, Stadler, Zsofia K., Van Guelpen, Bethany, Ulrich, Cornelia M., Li, Christopher I., Meester, Reinier, Moreno, Victor, Figueiredo, Jane C., Casey, Graham, Lansdorp Vogelaar, Iris, Dunlop, Malcolm G., Hayes, Richard B., Pharoah, Paul D. P., Houlston, Richard S., Jarvik, Gail P., Tomlinson, Ian P., Zheng, Wei, Corley, Douglas A.

Volltext

Identifying Novel Susceptibility Genes for Colorectal Cancer Risk From a Transcriptome-Wide Association Study of 125,478 Subjects von Guo, Xingyi, Lin, Weiqiang, Wen, Wanqing, Huyghe, Jeroen, Bien, Stephanie, Cai, Qiuyin, Harrison, Tabitha, Chen, Zhishan, Qu, Conghui, Bao, Jiandong, Long, Jirong, Yuan, Yuan, Wang, Fangqin, Bai, Mengqiu, Abecasis, Goncalo R., Albanes, Demetrius, Berndt, Sonja I., Bézieau, Stéphane, Bishop, D. Timothy, Brenner, Hermann, Buch, Stephan, Burnett-Hartman, Andrea, Campbell, Peter T., Castellví-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Cho, Sang Hee, Conti, David V., Chapelle, Albert de la, Feskens, Edith J.M., Gallinger, Steven J., Giles, Graham G., Goodman, Phyllis J., Gsur, Andrea, Guinter, Mark, Gunter, Marc J., Hampe, Jochen, Hampel, Heather, Hayes, Richard B., Hoffmeister, Michael, Kampman, Ellen, Kang, Hyun Min, Keku, Temitope O., Kim, Hyeong Rok, Le Marchand, Loic, Lee, Soo Chin, Li, Christopher I., Li, Li, Lindblom, Annika, Lindor, Noralane, Milne, Roger L., Moreno, Victor, Murphy, Neil, Newcomb, Polly A., Nickerson, Deborah A., Offit, Kenneth, Pearlman, Rachel, Pharoah, Paul D.P., Platz, Elizabeth A., Potter, John D., Rennert, Gad, Sakoda, Lori C., Schafmayer, Clemens, Schmit, Stephanie L., Schoen, Robert E., Schumacher, Fredrick R., Slattery, Martha L., Su, Yu-Ru, Tangen, Catherine M., Ulrich, Cornelia M., van Duijnhoven, Franzel J.B., Van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Wang, Xiaoliang, White, Emily, Wolk, Alicja, Woods, Michael O., Casey, Graham, Hsu, Li, Jenkins, Mark A., Gruber, Stephen B., Peters, Ulrike, Zheng, Wei

Volltext