Solubility-Driven Optimization of Phosphodiesterase‑4 Inhibitors Leading to a Clinical Candidate von Press, Neil J, Taylor, Roger J, Fullerton, Joseph D, Tranter, Pamela, McCarthy, Clive, Keller, Thomas H, Arnold, Nicola, Beer, David, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Hatto, Julia D. I, Keenan, Mark, Mercer, Mark K, Oakman, Helen, Sahri, Helene, Tuffnell, Andrew R, Tweed, Morris, Tyler, John W, Wagner, Trixie, Fozard, John R, Trifilieff, Alexandre

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Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmo... von Press, Neil J, Taylor, Roger J, Fullerton, Joseph D, Tranter, Pamela, McCarthy, Clive, Keller, Thomas H, Arnold, Nicola, Beer, David, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Hatto, Julia D I, Keenan, Mark, Mercer, Mark K, Oakman, Helen, Sahri, Helene, Tuffnell, Andrew R, Tweed, Morris, Trifilieff, Alexandre

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Potent and selective xanthine-based inhibitors of phosphodiesterase 5 von Arnold, Nichola J., Arnold, Ruth, Beer, David, Bhalay, Gurdip, Collingwood, Stephen P., Craig, Sarah, Devereux, Nicholas, Dodds, Mark, Dunstan, Andrew R., Fairhurst, Robin A., Farr, David, Fullerton, Joseph D., Glen, Angela, Gomez, Sylvie, Haberthuer, Sandra, Hatto, Julia D.I., Howes, Colin, Jones, Darryl, Keller, Thomas H., Leuenberger, Beate, Moser, Heinz E., Muller, Irene, Naef, Reto, Nicklin, Paul A., Sandham, David A., Turner, Katharine L., Tweed, Morris F., Watson, Simon J., Zurini, Mauro

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A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential von PRESS, Neil J, TAYLOR, Roger J, HATTO, Julia D. I, KEENAN, Mark, MERCER, Mark K, PRESS, Nicola E, SAHRI, Helene, TUFFNELL, Andrew R, TWEED, Morris, FOZARD, John R, FULLERTON, Joseph D, TRANTER, Pamela, MCCARTHY, Clive, KELLER, Thomas H, BROWN, Lyndon, CHEUNG, Robert, CHRISTIE, Julie, HABERTHUER, Sandra

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Discovery and Optimization of 4‑(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)­transcyclohexane­carboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pul... von Press, Neil J., Taylor, Roger J., Fullerton, Joseph D., Tranter, Pamela, McCarthy, Clive, Keller, Thomas H., Arnold, Nicola, Beer, David, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Hatto, Julia D. I., Keenan, Mark, Mercer, Mark K., Oakman, Helen, Sahri, Helene, Tuffnell, Andrew R., Tweed, Morris, Trifilieff, Alexandre

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Degradation of BRL 36650, a 6α-formamido penicillin: C(5)-C(6) bond cleavage von CUTMORE, E. A, GUEST, A. W, HATTO, J. D. I, SMALE, T. C, STACHULSKI, A. V, TYLER, J. W

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Aqueous and anhydrous degradations of 6?-formamidopenicillins von Cutmore, E. Alan, Guest, Angela W., Hatto, Julia D. I., Moores, Clive J., Smale, Terence C., Stachulski, Andrew V., Tyler, John W.

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Synthesis of derivatives of muramic acid and C-1 homologated α-D-glucose as potential inhibitors of bacterial transglycosylase von Brooks, Gerald, Edwards, Peter D., Hatto, Julia D.I., Smale, Terence C., Southgate, Robert

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A new orally bioavailable dual adenosine A 2B/A 3 receptor antagonist with therapeutic potential von Press, Neil J., Taylor, Roger J., Fullerton, Joseph D., Tranter, Pamela, McCarthy, Clive, Keller, Thomas H., Brown, Lyndon, Cheung, Robert, Christie, Julie, Haberthuer, Sandra, Hatto, Julia D.I., Keenan, Mark, Mercer, Mark K., Press, Nicola E., Sahri, Helene, Tuffnell, Andrew R., Tweed, Morris, Fozard, John R.

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Tetrahydroquinoline inhibitors of trypsin and thrombin von DEREK EDWARD BRUNDISH, JUDY D HAYLER, XIAO-LING COCKCROFT, PAUL IAN BUTLER, JOSEPH DAWSON FULLERTON, DARREN MARK LE GRAND, CLIVE VICTOR WALKER, WILLIAM BERNARD WATHEY, JULIA DORIS IDA HATTO, MARK CHRISTOPHER ALLEN, KEITH ALLAN MENEAR, PETER HEROLD, GARRICK PAUL SMITH, PETER DANIEL KANE

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