Activation and proteolytic activity of the Treponema pallidum metalloprotease, pallilysin von Houston, Simon, Hof, Rebecca, Honeyman, Lisa, Hassler, Julia, Cameron, Caroline E

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Mesoporous metal oxides for perovskite solar cells von Hassler, Julia

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RNAi modulation of placental sFLT1 for the treatment of preeclampsia von Turanov, Anton A, Lo, Agnes, Hassler, Matthew R, Makris, Angela, Ashar-Patel, Ami, Alterman, Julia F, Coles, Andrew H, Haraszti, Reka A, Roux, Loic, Godinho, Bruno M D C, Echeverria, Dimas, Pears, Suzanne, Iliopoulos, Jim, Shanmugalingam, Renuka, Ogle, Robert, Zsengeller, Zsuzsanna K, Hennessy, Annemarie, Karumanchi, S Ananth, Moore, Melissa J, Khvorova, Anastasia

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Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles von Haraszti, Reka Agnes, Miller, Rachael, Didiot, Marie-Cecile, Biscans, Annabelle, Alterman, Julia F., Hassler, Matthew R., Roux, Loic, Echeverria, Dimas, Sapp, Ellen, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia

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A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system von Alterman, Julia F., Godinho, Bruno M. D. C., Hassler, Matthew R., Ferguson, Chantal M., Echeverria, Dimas, Sapp, Ellen, Haraszti, Reka A., Coles, Andrew H., Conroy, Faith, Miller, Rachael, Roux, Loic, Yan, Paul, Knox, Emily G., Turanov, Anton A., King, Robert M., Gernoux, Gwladys, Mueller, Christian, Gray-Edwards, Heather L., Moser, Richard P., Bishop, Nina C., Jaber, Samer M., Gounis, Matthew J., Sena-Esteves, Miguel, Pai, Athma A., DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia

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Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo von Hassler, Matthew R, Turanov, Anton A, Alterman, Julia F, Haraszti, Reka A, Coles, Andrew H, Osborn, Maire F, Echeverria, Dimas, Nikan, Mehran, Salomon, William E, Roux, Loïc, Godinho, Bruno M D C, Davis, Sarah M, Morrissey, David V, Zamore, Phillip D, Karumanchi, S Ananth, Moore, Melissa J, Aronin, Neil, Khvorova, Anastasia

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Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing von Mir, Aamir, Alterman, Julia F., Hassler, Matthew R., Debacker, Alexandre J., Hudgens, Edward, Echeverria, Dimas, Brodsky, Michael H., Khvorova, Anastasia, Watts, Jonathan K., Sontheimer, Erik J.

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Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing von Didiot, Marie-Cécile, Hall, Lauren M, Coles, Andrew H, Haraszti, Reka A, Godinho, Bruno MDC, Chase, Kathryn, Sapp, Ellen, Ly, Socheata, Alterman, Julia F, Hassler, Matthew R, Echeverria, Dimas, Raj, Lakshmi, Morrissey, David V, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia

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Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington’s disease models von Conroy, Faith, Miller, Rachael, Alterman, Julia F., Hassler, Matthew R., Echeverria, Dimas, Godinho, Bruno M. D. C., Knox, Emily G., Sapp, Ellen, Sousa, Jaquelyn, Yamada, Ken, Mahmood, Farah, Boudi, Adel, Kegel-Gleason, Kimberly, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia, Pfister, Edith L.

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Spontaneous enteric nervous system activity generates contractile patterns prior to maturation of gastrointestinal motility von Dershowitz, Lori B, Bueno Garcia, Hassler, Perley, Andrew S, Coleman, Todd P, Kaltschmidt, Julia A

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Insights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation Profiling von Hassler, Melanie R., Pulverer, Walter, Lakshminarasimhan, Ranjani, Redl, Elisa, Hacker, Julia, Garland, Gavin D., Merkel, Olaf, Schiefer, Ana-Iris, Simonitsch-Klupp, Ingrid, Kenner, Lukas, Weisenberger, Daniel J., Weinhaeusel, Andreas, Turner, Suzanne D., Egger, Gerda

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Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain von Alterman, Julia F, Hall, Lauren M, Coles, Andrew H, Hassler, Matthew R, Didiot, Marie-Cecile, Chase, Kathryn, Abraham, Jasmin, Sottosanti, Emily, Johnson, Emily, Sapp, Ellen, Osborn, Maire F, Difiglia, Marian, Aronin, Neil, Khvorova, Anastasia

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An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis von Yenilmez, Batuhan, Wetoska, Nicole, Kelly, Mark, Echeverria, Dimas, Min, Kyounghee, Lifshitz, Lawrence, Alterman, Julia F., Hassler, Matthew R., Hildebrand, Samuel, DiMarzio, Chloe, McHugh, Nicholas, Vangjeli, Lorenc, Sousa, Jacquelyn, Pan, Meixia, Han, Xianlin, Brehm, Michael A., Khvorova, Anastasia, Czech, Michael P.

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Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition von Haraszti, Reka Agnes, Miller, Rachael, Dubuke, Michelle L, Rockwell, Hannah E, Coles, Andrew H, Sapp, Ellen, Didiot, Marie-Cecile, Echeverria, Dimas, Stoppato, Matteo, Sere, Yves Y, Leszyk, John, Alterman, Julia F, Godinho, Bruno M D C, Hassler, Matthew R, McDaniel, Justice, Narain, Niven R, Wollacott, Rachel, Wang, Yang, Shaffer, Scott A, Kiebish, Michael A, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia

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Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity von Yamada, Ken, Hildebrand, Samuel, Davis, Sarah M, Miller, Rachael, Conroy, Faith, Sapp, Ellen, Caiazzi, Jillian, Alterman, Julia F, Roux, Loic, Echeverria, Dimas, Hassler, Matthew R, Pfister, Edith L, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia

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PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs von Godinho, Bruno M.D.C., Knox, Emily G., Hildebrand, Samuel, Gilbert, James W., Echeverria, Dimas, Kennedy, Zachary, Haraszti, Reka A., Ferguson, Chantal M., Coles, Andrew H., Biscans, Annabelle, Caiazzi, Jillian, Alterman, Julia F., Hassler, Matthew R., Khvorova, Anastasia

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Enhancing siRNA efficacy in vivo with extended nucleic acid backbones von Yamada, Ken, Hariharan, Vignesh N, Caiazzi, Jillian, Miller, Rachael, Ferguson, Chantal M, Sapp, Ellen, Fakih, Hassan H, Tang, Qi, Yamada, Nozomi, Furgal, Raymond C, Paquette, Joseph D, Biscans, Annabelle, Bramato, Brianna M, McHugh, Nicholas, Summers, Ashley, Lochmann, Clemens, Godinho, Bruno M D C, Hildebrand, Samuel, Jackson, Samuel O, Echeverria, Dimas, Hassler, Matthew R, Alterman, Julia F, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia

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2′-O-Methyl at 20-mer Guide Strand 3′ Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA von Davis, Sarah M., Sousa, Jacquelyn, Vangjeli, Lorenc, Hassler, Matthew R., Echeverria, Dimas, Knox, Emily, Turanov, Anton A., Alterman, Julia F., Khvorova, Anastasia

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Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs von Osborn, Maire F, Alterman, Julia F, Nikan, Mehran, Cao, Hong, Didiot, Marie C, Hassler, Matthew R, Coles, Andrew H, Khvorova, Anastasia

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Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors von Cheng, Shun-Yun, Caiazzi, Jillian, Biscans, Annabelle, Alterman, Julia F., Echeverria, Dimas, McHugh, Nicholas, Hassler, Matthew, Jolly, Samson, Giguere, Delaney, Cipi, Joris, Khvorova, Anastasia, Punzo, Claudio

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