Combination Treatment of the Oral CHK1 Inhibitor, SRA737, and Low-Dose Gemcitabine Enhances the Effect of Programmed Death Ligand 1 Blockade by Modulating the Immune Microenvironme... von Sen, Triparna, Della Corte, Carminia M., Milutinovic, Snezana, Cardnell, Robert J., Diao, Lixia, Ramkumar, Kavya, Gay, Carl M., Stewart, C. Allison, Fan, Youhong, Shen, Li, Hansen, Ryan J., Strouse, Bryan, Hedrick, Michael P., Hassig, Christian A., Heymach, John V., Wang, Jing, Byers, Lauren A.

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Enhancing transcription–replication conflict targets ecDNA-positive cancers von Tang, Jun, Weiser, Natasha E., Wang, Guiping, Chowdhry, Sudhir, Curtis, Ellis J., Zhao, Yanding, Wong, Ivy Tsz-Lo, Marinov, Georgi K., Li, Rui, Hanoian, Philip, Tse, Edison, Mojica, Salvador Garcia, Hansen, Ryan, Plum, Joshua, Steffy, Auzon, Milutinovic, Snezana, Meyer, S. Todd, Luebeck, Jens, Wang, Yanbo, Zhang, Shu, Altemose, Nicolas, Curtis, Christina, Greenleaf, William J., Bafna, Vineet, Benkovic, Stephen J., Pinkerton, Anthony B., Kasibhatla, Shailaja, Hassig, Christian A., Mischel, Paul S., Chang, Howard Y.

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Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth von Iizuka, Shinji, Quintavalle, Manuela, Navarro, Jose C, Gribbin, Kyle P, Ardecky, Robert J, Abelman, Matthew M, Ma, Chen-Ting, Sergienko, Eduard, Zeng, Fu-Yue, Pass, Ian, Thomas, George V, McWeeney, Shannon K, Hassig, Christian A, Pinkerton, Anthony B, Courtneidge, Sara A

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Cardiac Glycosides Activate the Tumor Suppressor and Viral Restriction Factor Promyelocytic Leukemia Protein (PML) von Milutinovic, Snezana, Heynen-Genel, Susanne, Chao, Elizabeth, Dewing, Antimone, Solano, Ricardo, Milan, Loribelle, Barron, Nikki, He, Min, Diaz, Paul W, Matsuzawa, Shu-ichi, Reed, John C, Hassig, Christian A

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Three Proteins Define a Class of Human Histone Deacetylases Related to Yeast Hda1p von Grozinger, Christina M., Hassig, Christian A., Schreiber, Stuart L.

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Evidence That the DNA Endonuclease ARTEMIS also Has Intrinsic 5′-Exonuclease Activity von Li, Sicong, Chang, Howard H., Niewolik, Doris, Hedrick, Michael P., Pinkerton, Anthony B., Hassig, Christian A., Schwarz, Klaus, Lieber, Michael R.

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A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p von TAUNTON, J, HASSIG, C. A, SCHREIBER, S. L

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SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex von Feng, Yongmei, Pinkerton, Anthony B, Hulea, Laura, Zhang, Tongwu, Davies, Michael A, Grotegut, Stefan, Cheli, Yann, Yin, Hongwei, Lau, Eric, Kim, Hyungsoo, De, Surya K, Barile, Elisa, Pellecchia, Maurizio, Bosenberg, Marcus, Li, Jian-Liang, James, Brian, Hassig, Christian A, Brown, Kevin M, Topisirovic, Ivan, Ronai, Ze'ev A

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Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase von Nagy, Laszlo, Kao, Hung-Ying, Chakravarti, Debabrata, Lin, Richard J, Hassig, Christian A, Ayer, Donald E, Schreiber, Stuart L, Evans, Ronald M

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Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A von Hassig, Christian A, Fleischer, Tracey C, Billin, Andrew N, Schreiber, Stuart L, Ayer, Donald E

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Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex von Tong, Jeffrey K., Hassig, Christian A., Schnitzler, Gavin R., Kingston, Robert E., Schreiber, Stuart L.

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Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs von Hassig, Christian A, Schreiber, Stuart L

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Discovery of Dual Inducible/Neuronal Nitric Oxide Synthase (iNOS/nNOS) Inhibitor Development Candidate 4-((2-Cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2... von Payne, Joseph E, Bonnefous, Céline, Symons, Kent T, Nguyen, Phan M, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Wang, Li, Yazdani, Nahid, Shiau, Andrew K, Noble, Stewart A, Rix, Peter, Rao, Tadimeti S, Hassig, Christian A, Smith, Nicholas D

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A Role for Histone Deacetylase Activity in HDAC1-Mediated Transcriptional Repression von Hassig, Christian A., Tong, Jeffrey K., Fleischer, Tracey C., Owa, Takashi, Grable, Phyllis G., Ayer, Donald E., Schreiber, Stuart L.

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Inhibition of Melanoma Growth by Small Molecules That Promote the Mitochondrial Localization of ATF2 von VARSANO, Tal, LAU, Eric, YONGMEI FENG, GARRIDO, Marine, MILAN, Loribelle, HEYNEN-GENEL, Susanne, HASSIG, Christian A, RONAI, Ze'ev A

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KD5170, a novel mercaptoketone-based histone deacetylase inhibitor, exerts antimyeloma effects by DNA damage and mitochondrial signaling von Feng, Rentian, Ma, Huihui, Hassig, Christian A, Payne, Joseph E, Smith, Nicholas D, Mapara, Markus Y, Hager, Jeffrey H, Lentzsch, Suzanne

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CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer von Xu, Haineng, Gitto, Sarah B., Ho, Gwo-Yaw, Medvedev, Sergey, Shield-Artin, Kristy, Kim, Hyoung, Beard, Sally, Kinose, Yasuto, Wang, Xiaolei, Barker, Holly E., Ratnayake, Gayanie, Hwang, Wei-Ting, Hansen, Ryan J., Strouse, Bryan, Milutinovic, Snezana, Hassig, Christian, Wakefield, Matthew J., Vandenberg, Cassandra J., Scott, Clare L., Simpkins, Fiona

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Depudecin Induces Morphological Reversion of Transformed Fibroblasts via the Inhibition of Histone Deacetylase von Kwon, Ho Jeong, Owa, Takashi, Hassig, Christian A., Shimada, Junichi, Schreiber, Stuart L.

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Discovery of Inducible Nitric Oxide Synthase (iNOS) Inhibitor Development Candidate KD7332, Part 1: Identification of a Novel, Potent, and Selective Series of Quinolinone iNOS Dime... von Bonnefous, Céline, Payne, Joseph E, Roppe, Jeffrey, Zhuang, Hui, Chen, Xiaohong, Symons, Kent T, Nguyen, Phan M, Sablad, Marciano, Rozenkrants, Natasha, Zhang, Yan, Wang, Li, Severance, Daniel, Walsh, John P, Yazdani, Nahid, Shiau, Andrew K, Noble, Stewart A, Rix, Peter, Rao, Tadimeti S, Hassig, Christian A, Smith, Nicholas D

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Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins von Hassig, Christian A., Zeng, Fu-Yue, Kung, Paul, Kiankarimi, Mehrak, Kim, Sylvia, Diaz, Paul W., Zhai, Dayong, Welsh, Kate, Morshedian, Shana, Su, Ying, O’Keefe, Barry, Newman, David J., Rusman, Yudi, Kaur, Harneet, Salomon, Christine E., Brown, Susan G., Baire, Beeraiah, Michel, Andrew R., Hoye, Thomas R., Francis, Subhashree, Georg, Gunda I., Walters, Michael A., Divlianska, Daniela B., Roth, Gregory P., Wright, Amy E., Reed, John C.

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