Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models von Svensson, Robert U, Parker, Seth J, Eichner, Lillian J, Kolar, Matthew J, Wallace, Martina, Brun, Sonja N, Lombardo, Portia S, Van Nostrand, Jeanine L, Hutchins, Amanda, Vera, Lilliana, Gerken, Laurie, Greenwood, Jeremy, Bhat, Sathesh, Harriman, Geraldine, Westlin, William F, Harwood, H James, Saghatelian, Alan, Kapeller, Rosana, Metallo, Christian M, Shaw, Reuben J

Volltext

Treating the metabolic syndrome: acetyl-CoA carboxylase inhibition von Harwood Jr, H James

Volltext

Acetyl-coenzyme A carboxylases: Versatile targets for drug discovery von Tong, Liang, Harwood Jr, H. James

Volltext

Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase von Harwood, H. James, Petras, Stephen F., Hoover, Dennis J., Mankowski, Dayna C., Soliman, Victor F., Sugarman, Eliot D., Hulin, Bernard, Kwon, Younggil, Gibbs, E. Michael, Mayne, James T., Treadway, Judith L.

Volltext

Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2 von Corbett, Jeffrey W., Freeman-Cook, Kevin D., Elliott, Richard, Vajdos, Felix, Rajamohan, Francis, Kohls, Darcy, Marr, Eric, Zhang, Hailong, Tong, Liang, Tu, Meihua, Murdande, Sharad, Doran, Shawn D., Houser, Janet A., Song, Wei, Jones, Christopher J., Coffey, Steven B., Buzon, Leanne, Minich, Martha L., Dirico, Kenneth J., Tapley, Susan, Kirk McPherson, R., Sugarman, Eliot, James Harwood, H., Esler, William

Volltext

Cryo-EM structure of human ATP-citrate lyase in complex with a potent inhibitor von Wei, Jia, Leit, Silvana, Kuai, Jun, Therrien, Eric, Rafi, Salma, Harwood Jr, H. James, DeLaBarre, Byron, Tong, Liang

Volltext

Old World nonhuman primate models of type 2 diabetes mellitus von Wagner, J.D, Kavanagh, K, Ward, G.M, Auerbach, B.J, Harwood, H.J. Jr, Kaplan, J.R

Volltext

A selective cannabinoid-1 receptor antagonist, PF-95453, reduces body weight and body fat to a greater extent than pair-fed controls in obese monkeys von Wagner, Janice D, Zhang, Li, Kavanagh, Kylie, Ward, Gina M, Chin, Janice E, Hadcock, John R, Auerbach, Bruce J, Harwood, Jr, H James

Volltext

HMG-CoA reductase regulation: use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator prod... von Petras, S F, Lindsey, S, Harwood, Jr, H J

Volltext

Partial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npcnih null mice brains reduces neuronal cholesterol accumulation,... von Reid, Patrick C, Lin, Song, Vanier, Marie T, Ohno-Iwashita, Yoshiko, Harwood, Jr, H James, Hickey, William F, Chang, Catherine C Y, Chang, Ta Yuan

Volltext

Inhibition of Mammalian Squalene Synthetase Activity by Zaragozic Acid A Is a Result of Competitive Inhibition Followed by Mechanism-based Irreversible Inactivation von Lindsey, S, Harwood, Jr, H J

Volltext

CP-346086 von Chandler, Charles E., Wilder, Donald E., Pettini, Judith L., Savoy, Yvette E., Petras, Stephen F., Chang, George, Vincent, John, Harwood, H. James

Volltext

In Vivo LDL Receptor and HMG-CoA Reductase Regulation in Human Lymphocytes and Its Alterations During Aging von Stulnig, Thomas M, Klocker, Helmut, Harwood, Jr, Jurgens, Gunther, Schonitzer, Dieter, Jarosch, Elmar, Huber, Lukas A, Amberger, Albert, Wick, Georg

Volltext

Crystal Structure of Human Squalene Synthase von Pandit, Jayvardhan, Danley, Dennis E., Schulte, Gayle K., Mazzalupo, Stacy, Pauly, Thomas A., Hayward, Cheryl M., Hamanaka, Ernest S., Thompson, John F., Harwood, H. James

Volltext

Modulators of dyslipidaemia von Harwood, Jr, H James, Hamanaka, Ernest S

Volltext

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour von Kaelin, William G, Marin, Maria Carmen, Jost, Christine A, Brooks, Louise A, Irwin, Meredith S, O'Nions, Jenny, Tidy, John A, James, Nick, McGregor, Jane M, Harwood, Catherine A, Yulug, Isik G, Vousden, Karen H, Allday, Martin J, Gusterson, Barry, Ikawa, Shuntaro, Hinds, Philip W, Crook, Tim

Volltext

Immunoassay of infectious agents von Andreotti, Peter E, Ludwig, George V, Peruski, Anne Harwood, Tuite, James J, Morse, Stephen S, Peruski, Leonard F

Volltext

Effects of l-Triiodothyronine and the Thyromimetic L-94901 on Serum Lipoprotein Levels and Hepatic Low-Density Lipoprotein Receptor, 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase... von Ness, Gene C, Lopez, Dayami, Chambers, Christopher M, Newsome, William P, Cornelius, Peter, Long, Catherine A, Harwood, H.James

Volltext

Kinetics of low-density lipoprotein receptor activity in Hep-G2 cells: derivation and validation of a Briggs-Haldane-based kinetic model for evaluating receptor-mediated endocytoti... von Harwood, Jr, H J, Pellarin, L D

Volltext

3-(4-Chlorophenyl)-2-(4-diethylaminoethoxyphenyl)-a-pentenonitrile monohydrogen citrate and related analogs: Reversible, competitive, first half-reaction squalene synthetase inhibi... von Harwood, H.James, Barbacci-Tobin, Elsa G., Petras, Stephen F., Lindsey, Saralyn, Pellarin, Lorraine D.

Volltext