A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity von Compte, Marta, Harwood, Seandean Lykke, Muñoz, Ines G., Navarro, Rocio, Zonca, Manuela, Perez-Chacon, Gema, Erce-Llamazares, Ainhoa, Merino, Nekane, Tapia-Galisteo, Antonio, Cuesta, Angel M., Mikkelsen, Kasper, Caleiras, Eduardo, Nuñez-Prado, Natalia, Aznar, M. Angela, Lykkemark, Simon, Martínez-Torrecuadrada, Jorge, Melero, Ignacio, Blanco, Francisco J., Bernardino de la Serna, Jorge, Zapata, Juan M., Sanz, Laura, Alvarez-Vallina, Luis

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Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer von Tapia-Galisteo, Antonio, Sánchez Rodríguez, Íñigo, Aguilar-Sopeña, Oscar, Harwood, Seandean Lykke, Narbona, Javier, Ferreras Gutierrez, Mariola, Navarro, Rocío, Martín-García, Laura, Corbacho, Cesáreo, Compte, Marta, Lacadena, Javier, Blanco, Francisco J., Chames, Patrick, Roda-Navarro, Pedro, Álvarez-Vallina, Luis, Sanz, Laura

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The coming of age of engineered multivalent antibodies von Nuñez-Prado, Natalia, Compte, Marta, Harwood, Seandean, Álvarez-Méndez, Ana, Lykkemark, Simon, Sanz, Laura, Álvarez-Vallina, Luis

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Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies von Mikkelsen, Kasper, Harwood, Seandean Lykke, Compte, Marta, Merino, Nekane, Mølgaard, Kasper, Lykkemark, Simon, Alvarez-Mendez, Ana, Blanco, Francisco J, Álvarez-Vallina, Luis

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A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response von Rubio-Pérez, Laura, Lázaro-Gorines, Rodrigo, Harwood, Seandean L., Compte, Marta, Navarro, Rocío, Tapia-Galisteo, Antonio, Bonet, Jaume, Blanco, Belén, Lykkemark, Simon, Ramírez-Fernández, Ángel, Ferreras-Gutiérrez, Mariola, Domínguez-Alonso, Carmen, Díez-Alonso, Laura, Segura-Tudela, Alejandro, Hangiu, Oana, Erce-Llamazares, Ainhoa, Blanco, Francisco J., Santos, Cruz, Rodríguez-Peralto, José L., Sanz, Laura, Álvarez-Vallina, Luis

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An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity von Compte, Marta, Harwood, Seandean L., Erce-Llamazares, Ainhoa, Tapia-Galisteo, Antonio, Romero, Eduardo, Ferrer, Irene, Garrido-Martin, Eva M., Enguita, Ana B., Ochoa, Maria C., Blanco, Belen, Oteo, Marta, Merino, Nekane, Nehme-Alvarez, Daniel, Hangiu, Oana, Dominguez-Alonso, Carmen, Zonca, Manuela, Ramirez-Fernandez, Angel, Blanco, Francisco J., Morcillo, Miguel A., Munoz, Ines G., Melero, Ignacio, Rodriguez-Peralto, Jose L., Paz-Ares, Luis, Sanz, Laura, Alvarez-Vallina, Luis

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Bispecific light T-cell engagers for gene-based immunotherapy of epidermal growth factor receptor (EGFR)-positive malignancies von Mølgaard, Kasper, Harwood, Seandean L., Compte, Marta, Merino, Nekane, Bonet, Jaume, Alvarez-Cienfuegos, Ana, Mikkelsen, Kasper, Nuñez-Prado, Natalia, Alvarez-Mendez, Ana, Sanz, Laura, Blanco, Francisco J., Alvarez-Vallina, Luis

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Case Report: An EGFR-Targeted 4-1BB-agonistic Trimerbody Does Not Induce Hepatotoxicity in Transgenic Mice With Liver Expression of Human EGFR von Compte, Marta, Harwood, Seandean L., Martinez-Torrecuadrada, Jorge, Perez-Chacon, Gema, Gonzalez-Garcia, Patricia, Tapia-Galisteo, Antonio, Van Bergen en Henegouwen, Paul M. P., Sanchez, Aranzazu, Fabregat, Isabel, Sanz, Laura, Zapata, Juan M., Alvarez-Vallina, Luis

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Characterization of a Trispecific PD-L1 Blocking Antibody That Exhibits EGFR-Conditional 4-1BB Agonist Activity von Rubio-Pérez, Laura, Frago, Susana, Compte, Marta, Navarro, Rocío, Harwood, Seandean L, Lázaro-Gorines, Rodrigo, Gómez-Rosel, Marina, Hangiu, Oana, Silva-Pilipich, Noelia, Vanrell, Lucía, Smerdou, Cristian, Álvarez-Vallina, Luis

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Development of selective protease inhibitors via engineering of the bait region of human α2-macroglobulin von Harwood, Seandean Lykke, Nielsen, Nadia Sukusu, Diep, Khang, Jensen, Kathrine Tejlgård, Nielsen, Peter Kresten, Yamamoto, Kazuhiro, Enghild, Jan J.

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Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers von Blanco, Belén, Ramírez-Fernández, Ángel, Bueno, Clara, Argemí-Muntadas, Lidia, Fuentes, Patricia, Aguilar-Sopeña, Óscar, Gutierrez-Agüera, Francisco, Zanetti, Samanta Romina, Tapia-Galisteo, Antonio, Díez-Alonso, Laura, Segura-Tudela, Alejandro, Castellà, Maria, Marzal, Berta, Betriu, Sergi, Harwood, Seandean L, Compte, Marta, Lykkemark, Simon, Erce-Llamazares, Ainhoa, Rubio-Pérez, Laura, Jiménez-Reinoso, Anaïs, Domínguez-Alonso, Carmen, Neves, Maria, Morales, Pablo, Paz-Artal, Estela, Guedan, Sonia, Sanz, Laura, Toribio, María L, Roda-Navarro, Pedro, Juan, Manel, Menéndez, Pablo, Álvarez-Vallina, Luis

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Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicity von Hangiu, Oana, Compte, Marta, Dinesen, Anders, Navarro, Rocio, Tapia-Galisteo, Antonio, Mandrup, Ole A., Erce-Llamazares, Ainhoa, Lázaro-Gorines, Rodrigo, Nehme-Álvarez, Daniel, Domínguez-Alonso, Carmen, Harwood, Seandean L., Alfonso, Carlos, Blanco, Belen, Rubio-Pérez, Laura, Jiménez-Reinoso, Anaïs, Díez-Alonso, Laura, Blanco, Francisco J., Sanz, Laura, Howard, Kenneth A., Álvarez-Vallina, Luis

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Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family von Nielsen, Nadia Sukusu, Zarantonello, Alessandra, Harwood, Seandean Lykke, Jensen, Kathrine Tejlgård, Kjøge, Katarzyna, Thøgersen, Ida B., Schauser, Leif, Karlsen, Jesper Lykkegaard, Andersen, Gregers R., Enghild, Jan J.

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Dendritic Cell‐Mediated Cross‐Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS‐CoV‐2 von Lázaro‐Gorines, Rodrigo, Pérez, Patricia, Heras‐Murillo, Ignacio, Adán‐Barrientos, Irene, Albericio, Guillermo, Astorgano, David, Flores, Sara, Luczkowiak, Joanna, Labiod, Nuria, Harwood, Seandean L., Segura‐Tudela, Alejandro, Rubio‐Pérez, Laura, Nugraha, Yudhi, Shang, Xiaoran, Li, Yuxing, Alfonso, Carlos, Adipietro, Kaylin A., Abeyawardhane, Dinendra L., Navarro, Rocío, Compte, Marta, Yu, Wenbo, MacKerell, Alexander D., Sanz, Laura, Weber, David J., Blanco, Francisco J., Esteban, Mariano, Pozharski, Edwin, Godoy‐Ruiz, Raquel, Muñoz, Inés G., Delgado, Rafael, Sancho, David, García‐Arriaza, Juan, Álvarez‐Vallina, Luis

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Characterization of a novel cold-adapted intracellular serine protease from the extremophile Planococcus halocryophilus Or1 von Rasmussen, Casper Bøjer, Scavenius, Carsten, Thøgersen, Ida B, Harwood, Seandean Lykke, Larsen, Øivind, Bjerga, Gro Elin Kjaereng, Stougaard, Peter, Enghild, Jan J, Thøgersen, Mariane Schmidt

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ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy von Harwood, Seandean Lykke, Alvarez-Cienfuegos, Ana, Nuñez-Prado, Natalia, Compte, Marta, Hernández-Pérez, Sara, Merino, Nekane, Bonet, Jaume, Navarro, Rocio, Van Bergen en Henegouwen, Paul M. P., Lykkemark, Simon, Mikkelsen, Kasper, Mølgaard, Kasper, Jabs, Frederic, Sanz, Laura, Blanco, Francisco J., Roda-Navarro, Pedro, Alvarez-Vallina, Luis

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Engineering New Protease Inhibitors Using α2-Macroglobulin von Harwood, Seandean Lykke, Enghild, Jan J.

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Recent cryogenic electron microscopy structures of human A2M may not be representative of the native protein von Harwood, Seandean Lykke, Andersen, Gregers Rom, Enghild, Jan J.

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Proteolytic cleavage of the TGF β co‐receptor CD 109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the cell me... von Jensen, Kathrine Tejlgård, Nielsen, Nadia Sukusu, Viana Almeida, Ana, Thøgersen, Ida B., Enghild, Jan J., Harwood, Seandean Lykke

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Development of selective protease inhibitors via engineering of the bait region of human alpha(2)-macroglobulin von Harwood, Seandean Lykke, Nielsen, Nadia Sukusu, Diep, Khang, Jensen, Kathrine Tejlgard, Nielsen, Peter Kresten, Yamamoto, Kazuhiro, Enghild, Jan J.

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