Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate von Slater, Martin J, Amphlett, Elizabeth M, Andrews, David M, Bravi, Gianpaolo, Burton, George, Cheasty, Anne G, Corfield, John A, Ellis, Malcolm R, Fenwick, Rebecca H, Fernandes, Stephanie, Guidetti, Rossella, Haigh, David, Hartley, C. David, Howes, Peter D, Jackson, Deborah L, Jarvest, Richard L, Lovegrove, Victoria L. H, Medhurst, Katrina J, Parry, Nigel R, Price, Helen, Shah, Pritom, Singh, Onkar M. P, Stocker, Richard, Thommes, Pia, Wilkinson, Claire, Wonacott, Alan

Volltext

Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors von Swarbrick, Martin E., Beswick, Paul J., Gleave, Robert J., Green, Richard H., Bingham, Sharon, Bountra, Chas, Carter, Malcolm C., Chambers, Laura J., Chessell, Iain P., Clayton, Nick M., Collins, Sue D., Corfield, John A., Hartley, C. David, Kleanthous, Savvas, Lambeth, Paul F., Lucas, Fiona S., Mathews, Neil, Naylor, Alan, Page, Lee W., Payne, Jeremy J., Pegg, Neil A., Price, Helen S., Skidmore, John, Stevens, Alexander J., Stocker, Richard, Stratton, Sharon C., Stuart, Alastair J., Wiseman, Joanne O.

Volltext

View from the frontline von Hartley, David C

Volltext

View from the frontline von Hartley, David C

Volltext

Semi-synthetic qualestatins: Squalene synthase inhibition and antifungal activity. The SAR of C6 and C7 modifications von Giblin, Gerard M.P., Bell, Richard, Hancock, Ashley P, Hartley, C David, Inglis, Graham G.A., Payne, Jeremy J, Procopiou, Panayiotis A, Shingler, Anthony H, Smith, Colin, Spooner, Stephen J

Volltext

Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimi-dinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors von SWARBRICK, Martin E, BESWICK, Paul J, COLLINS, Sue D, CORFIELD, John A, HARTLEY, C. David, KLEANTHOUS, Sawas, LAMBETH, Paul F, LUCAS, Fiona S, MATHEWS, Neil, NAYLOR, Alan, PAGE, Lee W, PAYNE, Jeremy J, GLEAVE, Robert J, PEGG, Neil A, PRICE, Helen S, SKIDMORE, John, STEVENS, Alexander J, STOCKER, Richard, STRATTON, Sharon C, STUART, Alastair J, WISEMAN, Joanne O, GREEN, Richard H, BINGHAM, Sharon, BOUNTRA, Chas, CARTER, Malcolm C, CHAMBERS, Laura J, CHESSELL, Lain P, CLAYTON, Nick M

Volltext

Performance Characteristics of Adenoid Cystic Carcinoma of the Salivary Gland in Fine Needle Aspirates: Results from the CAP Non-Gynecologic Cytology Program von Khalbuss, Walid, MD, PhD, Auger, Manon, MD, Laser, Alice, MD, Laucirica, Rodolfo, MD, Barkan, Guliz, MD, Souers, Rhona, MS, Crothers, Barbara, DO, Kurtycz, Daniel, MD, Hartley, David, CT(ASCP), Tabatabai, Laura, MD

Volltext

Inhibitors of cholesterol biosynthesis. 1. 3,5-Dihydroxy-7-(N-imidazolyl)-6-heptenoates and -heptanoates, a novel series of HMG-CoA reductase inhibitors von Chan, C, Bailey, E J, Hartley, C D, Hayman, D F, Hutson, J L, Inglis, G G, Jones, P S, Keeling, S E, Kirk, B E, Lamont, R B

Volltext

Inhibitors of cholesterol biosynthesis. 1. 3,5-Dihydroxy-7-(N-imidazolyl)-6-heptenoates and -heptanoates, a novel series of 3-hydroxy-3-methylglutarate-CoA reductase inhibitors von Chan, Chuen, Bailey, Esme J, Hartley, C. David, Hayman, David F, Hutson, Julie L, Inglis, Graham G. A, Jones, Paul S, Keeling, Suzanne E, Kirk, Barrie E

Volltext

PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer von Mehanna, Hisham, Wong, Wai-Lup, McConkey, Christopher C, Rahman, Joy K, Robinson, Max, Hartley, Andrew G.J, Nutting, Christopher, Powell, Ned, Al-Booz, Hoda, Robinson, Martin, Junor, Elizabeth, Rizwanullah, Mohammed, V. von Zeidler, Sandra, Wieshmann, Hulya, Hulme, Claire, Smith, Alison F, Hall, Peter, Dunn, Janet

Volltext

Chromosome-scale shotgun assembly using an in vitro method for long-range linkage von Putnam, Nicholas H, O'Connell, Brendan L, Stites, Jonathan C, Rice, Brandon J, Blanchette, Marco, Calef, Robert, Troll, Christopher J, Fields, Andrew, Hartley, Paul D, Sugnet, Charles W, Haussler, David, Rokhsar, Daniel S, Green, Richard E

Volltext

Genomic evidence for reinfection with SARS-CoV-2: a case study von Tillett, Richard L, Sevinsky, Joel R, Hartley, Paul D, Kerwin, Heather, Crawford, Natalie, Gorzalski, Andrew, Laverdure, Chris, Verma, Subhash C, Rossetto, Cyprian C, Jackson, David, Farrell, Megan J, Van Hooser, Stephanie, Pandori, Mark

Volltext

FAAH genetic variation enhances fronto-amygdala function in mouse and human von Dincheva, Iva, Drysdale, Andrew T., Hartley, Catherine A., Johnson, David C., Jing, Deqiang, King, Elizabeth C., Ra, Stephen, Gray, J. Megan, Yang, Ruirong, DeGruccio, Ann Marie, Huang, Chienchun, Cravatt, Benjamin F., Glatt, Charles E., Hill, Matthew N., Casey, B. J., Lee, Francis S.

Volltext

Exacerbations of Chronic Obstructive Pulmonary Disease and Cardiac Events. A Post Hoc Cohort Analysis from the SUMMIT Randomized Clinical Trial von Kunisaki, Ken M, Dransfield, Mark T, Anderson, Julie A, Brook, Robert D, Calverley, Peter M A, Celli, Bartolome R, Crim, Courtney, Hartley, Benjamin F, Martinez, Fernando J, Newby, David E, Pragman, Alexa A, Vestbo, Jørgen, Yates, Julie C, Niewoehner, Dennis E

Volltext

Neurotranscriptomics: The Effects of Neonatal Stimulus Deprivation on the Rat Pineal Transcriptome von Hartley, Stephen W, Coon, Steven L, Savastano, Luis E, Mullikin, James C, Fu, Cong, Klein, David C

Volltext

CBFβ Stabilizes HIV Vif to Counteract APOBEC3 at the Expense of RUNX1 Target Gene Expression von Kim, Dong Young, Kwon, Eunju, Hartley, Paul D., Crosby, David C., Mann, Sumanjit, Krogan, Nevan J., Gross, John D.

Volltext

ADCT-402, a PBD dimer–containing antibody drug conjugate targeting CD19-expressing malignancies von Zammarchi, Francesca, Corbett, Simon, Adams, Lauren, Tyrer, Peter C., Kiakos, Konstantinos, Janghra, Narinder, Marafioti, Teresa, Britten, Charles E., Havenith, Carin E.G., Chivers, Simon, D'Hooge, Francois, Williams, David G., Tiberghien, Arnaud, Howard, Philip W., Hartley, John A., van Berkel, Patrick H.

Volltext

Association Between Statewide School Closure and COVID-19 Incidence and Mortality in the US von Auger, Katherine A, Shah, Samir S, Richardson, Troy, Hartley, David, Hall, Matthew, Warniment, Amanda, Timmons, Kristen, Bosse, Dianna, Ferris, Sarah A, Brady, Patrick W, Schondelmeyer, Amanda C, Thomson, Joanna E

Volltext

An early validation of the Society for Vascular Surgery Lower Extremity Threatened Limb Classification System von Cull, David L., MD, Manos, Ginger, MD, Hartley, Michael C., MD, Taylor, Spence M., MD, Langan, Eugene M., MD, Eidt, John F., MD, Johnson, Brent L., MS

Volltext

ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies von Flynn, Michael J, Zammarchi, Francesca, Tyrer, Peter C, Akarca, Ayse U, Janghra, Narinder, Britten, Charles E, Havenith, Carin E G, Levy, Jean-Noel, Tiberghien, Arnaud, Masterson, Luke A, Barry, Conor, D'Hooge, Francois, Marafioti, Teresa, Parren, Paul W H I, Williams, David G, Howard, Philip W, van Berkel, Patrick H, Hartley, John A

Volltext