Molecular Landscape and Actionable Alterations in a Genomically Guided Cancer Clinical Trial: National Cancer Institute Molecular Analysis for Therapy Choice (NCI-MATCH) von Flaherty, Keith T., Gray, Robert J., Chen, Alice P., Li, Shuli, McShane, Lisa M., Patton, David, Hamilton, Stanley R., Williams, P. Mickey, Iafrate, A. John, Sklar, Jeffrey, Mitchell, Edith P., Harris, Lyndsay N., Takebe, Naoko, Sims, David J., Coffey, Brent, Fu, Tony, Routbort, Mark, Zwiebel, James A., Rubinstein, Larry V., Little, Richard F., Arteaga, Carlos L., Comis, Robert, Abrams, Jeffrey S., O'Dwyer, Peter J., Conley, Barbara A.

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A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers von Szallasi, Zoltan, Carter, Scott L, Eklund, Aron C, Kohane, Isaac S, Harris, Lyndsay N

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The Challenge for Development of Valuable Immuno-oncology Biomarkers von Mehnert, Janice M, Monjazeb, Arta M, Beerthuijzen, Johanna M T, Collyar, Deborah, Rubinstein, Larry, Harris, Lyndsay N

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Immune Signatures Following Single Dose Trastuzumab Predict Pathologic Response to PreoperativeTrastuzumab and Chemotherapy in HER2-Positive Early Breast Cancer von Varadan, Vinay, Gilmore, Hannah, Miskimen, Kristy L S, Tuck, David, Parsai, Shikha, Awadallah, Amad, Krop, Ian E, Winer, Eric P, Bossuyt, Veerle, Somlo, George, Abu-Khalaf, Maysa M, Fenton, Mary Anne, Sikov, William, Harris, Lyndsay N

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Molecular phenotypes in triple negative breast cancer from African American patients suggest targets for therapy von Lindner, Robert, Sullivan, Catherine, Offor, Onyinye, Lezon-Geyda, Kimberly, Halligan, Kyle, Fischbach, Neal, Shah, Mansi, Bossuyt, Veerle, Schulz, Vincent, Tuck, David P, Harris, Lyndsay N

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Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin von McAllister, Sandra S., Gifford, Ann M., Greiner, Ashley L., Kelleher, Stephen P., Saelzler, Matthew P., Ince, Tan A., Reinhardt, Ferenc, Harris, Lyndsay N., Hylander, Bonnie L., Repasky, Elizabeth A., Weinberg, Robert A.

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Recursive SVM feature selection and sample classification for mass-spectrometry and microarray data von Zhang, Xuegong, Lu, Xin, Shi, Qian, Xu, Xiu-Qin, Leung, Hon-Chiu E, Harris, Lyndsay N, Iglehart, James D, Miron, Alexander, Liu, Jun S, Wong, Wing H

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HER2 and Chromosome 17 Effect on Patient Outcome in the N9831 Adjuvant Trastuzumab Trial von PEREZ, Edith A, REINHOLZ, Monica M, DUECK, Amylou C, KETTERLING, Rhett P, INGLE, James N, LINGLE, Wilma L, KAUFMAN, Peter A, VISSCHER, Daniel W, JENKINS, Robert B, HILLMAN, David W, TENNER, Kathleen S, SCHFOEDER, Matthew J, DAVIDSON, Nancy E, MARTINO, Silvana, SLEDGE, George W, HARRIS, Lyndsay N, GRALOW, Julie R

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Trastuzumab-Induced HER Reprogramming in Resistant Breast Carcinoma Cells von NARAYAN, Murli, WILKEN, Jason A, HARRIS, Lyndsay N, BARON, Andre T, KIMBLER, Kimberly D, MAIHLE, Nita J

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Impact of PTEN Protein Expression on Benefit From Adjuvant Trastuzumab in Early-Stage Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer in the North Central Cancer Tr... von PEREZ, Edith A, DUECK, Amylou C, KUTTEH, Leila A, SLEDGE, George W, HARRIS, Lyndsay N, GRALOW, Julie R, REINHOLZ, Monica M, MCCULLOUGH, Ann E, BEIYUN CHEN, GEIGER, Xochiquetzal J, JENKINS, Robert B, LINGLE, Wilma L, DAVIDSON, Nancy E, MARTINO, Silvana, KAUFMAN, Peter A

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Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy von Hirukawa, Alison, Singh, Salendra, Wang, Jarey, Rennhack, Jonathan P., Swiatnicki, Matthew, Sanguin-Gendreau, Virginie, Zuo, Dongmei, Daldoul, Kamilia, Lavoie, Cynthia, Park, Morag, Andrechek, Eran R., Westbrook, Thomas F., Harris, Lyndsay N., Varadan, Vinay, Smith, Harvey W., Muller, William J.

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An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis von Smith, Harvey W., Hirukawa, Alison, Sanguin-Gendreau, Virginie, Nandi, Ipshita, Dufour, Catherine R., Zuo, Dongmei, Tandoc, Kristofferson, Leibovitch, Matthew, Singh, Salendra, Rennhack, Jonathan P., Swiatnicki, Matthew, Lavoie, Cynthia, Papavasiliou, Vasilios, Temps, Carolin, Carragher, Neil O., Unciti-Broceta, Asier, Savage, Paul, Basik, Mark, van Hoef, Vincent, Larsson, Ola, Cooper, Caroline L., Vargas Calderon, Ana Cristina, Beith, Jane, Millar, Ewan, Selinger, Christina, Giguère, Vincent, Park, Morag, Harris, Lyndsay N., Varadan, Vinay, Andrechek, Eran R., O’Toole, Sandra A., Topisirovic, Ivan, Muller, William J.

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Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer von VOGEL, Charles L, COBLEIGH, Melody A, SHAK, Steven, STEWART, Stanford J, PRESS, Michael, TRIPATHY, Debu, GUTHEIL, John C, HARRIS, Lyndsay N, FEHRENBACHER, Louis, SLAMON, Dennis J, MURPHY, Maureen, NOVOTNY, William F, BURCHMORE, Michael

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Stathmin expression and its relationship to microtubule‐associated protein tau and outcome in breast cancer von Baquero, Maria T., Hanna, Jason A., Neumeister, Veronique, Cheng, Huan, Molinaro, Annette M., Harris, Lyndsay N., Rimm, David L.

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Predictors of Resistance to Preoperative Trastuzumab and Vinorelbine for HER2-Positive Early Breast Cancer von Harris, Lyndsay N, You, Fanglei, Schnitt, Stuart J, Witkiewicz, Agnes, Lu, Xin, Sgroi, Dennis, Ryan, Paula D, Come, Steven E, Burstein, Harold J, Lesnikoski, Beth-Ann, Kamma, Madhavi, Friedman, Paula N, Gelman, Rebecca, Iglehart, J Dirk, Winer, Eric P

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VEGF as a Marker for Outcome Among Advanced Breast Cancer Patients Receiving anti-VEGF Therapy with Bevacizumab and Vinorelbine Chemotherapy von BURSTEIN, Harold J, CHEN, Yu-Hui, SHULMAN, Lawrence N, HARRIS, Lyndsay N, GELMAN, Rebecca, WINER, Eric P, PARKER, Leroy M, SAVOIE, Jennifer, YOUNGER, Jerry, KUTER, Irene, RYAN, Paula D, GARBER, Judy E, HELEN CHEN, CAMPOS, Susana M

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A role for the scaffolding adapter GAB2 in breast cancer von Bentires-Alj, Mohamed, Gu, Haihua, Gil, Susana G, Chan, Richard, Wang, Zhigang C, Wang, Yongping, Imanaka, Naoko, Harris, Lyndsay N, Richardson, Andrea, Neel, Benjamin G

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Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideli... von Harris, Lyndsay N, Ismaila, Nofisat, McShane, Lisa M, Andre, Fabrice, Collyar, Deborah E, Gonzalez-Angulo, Ana M, Hammond, Elizabeth H, Kuderer, Nicole M, Liu, Minetta C, Mennel, Robert G, Van Poznak, Catherine, Bast, Robert C, Hayes, Daniel F

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Trastuzumab and Vinorelbine as First-Line Therapy for HER2-Overexpressing Metastatic Breast Cancer: Multicenter Phase II Trial With Clinical Outcomes, Analysis of Serum Tumor Marke... von BURSTEIN, Harold J, HARRIS, Lyndsay N, RYAN, Paula D, ELLIS, Mathew J, NUNES, Raquel A, BUNNELL, Craig A, CAMPOS, Susana M, HALLOR, Michele, GELMAN, Rebecca, WINER, Eric P, MARCOM, P. Kelly, LAMBERT-FALLS, Rosemary, HAVLIN, Kathleen, OVERMOYER, Beth, FRIEDLANDER, Robert J, GARGIULO, Janet, STRENGER, Rochelle, VOGEL, Charles L

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Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors von Goel, Shom, Wang, Qi, Watt, April C., Tolaney, Sara M., Dillon, Deborah A., Li, Wei, Ramm, Susanne, Palmer, Adam C., Yuzugullu, Haluk, Varadan, Vinay, Tuck, David, Harris, Lyndsay N., Wong, Kwok-Kin, Liu, X. Shirley, Sicinski, Piotr, Winer, Eric P., Krop, Ian E., Zhao, Jean J.

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