Reduced drug accumulation as a major mechanism of acquired resistance to cisplatin in a human ovarian carcinoma cell line: circumvention studies using novel platinum (II) and (IV)... von Loh, SY, Mistry, P, Kelland, LR, Abel, G, Harrap, KR

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Preclinical antitumor evaluation of bis-acetato-ammine-dichloro-cyclohexylamine platinum(IV) : an orally active platinum drug von KELLAND, L. R, ABEL, G, MCKEAGE, M. J, JONES, M, GODDARD, P. M, VALENTI, M, MURRER, B. A, HARRAP, K. R

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A novel trans-platinum coordination complex possessing in vitro and in vivo antitumor activity von KELLAND, L. R, BARNARD, C. F. J, MELLISH, K. J, JONES, M, GODDARD, P. M, VALENTI, M, BRYANT, A, MURRER, B. A, HARRAP, K. R

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Phase I and pharmacokinetic study of an oral platinum complex given daily for 5 days in patients with cancer von MCKEAGE, M. J, RAYNAUD, F, WARD, J, BERRY, C, O'DELL, D, KELLAND, L. R, MURRER, B, SANTABARABARA, P, HARRAP, K. R, JUDSON, I. R

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The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines von Mistry, P, Kelland, LR, Abel, G, Sidhar, S, Harrap, KR

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Ammine/amine platinum(IV) dicarboxylates : a novel class of platinum complex exhibiting selective cytotoxicity to intrinsically cisplatin-resistant human ovarian carcinoma cell lin... von KELLAND, L. R, MURRER, B. A, ABEL, G, GIANDOMENICO, C. M, MISTRY, P, HARRAP, K. R

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Cisplatin Induces Apoptosis in a Human Ovarian Carcinoma Cell Line without Concomitant Internucleosomal Degradation of DNA von Ormerod, M.G., O'Neill, C.F., Robertson, D., Harrap, K.R.

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ZD1694 (Tomudex): A new thymidylate synthase inhibitor with activity in colorectal cancer von Jackman, A.L, Farrugia, D.C, Gibson, W, Kimbell, R, Harrap, K.R, Stephens, T.C, Azab, M, Boyle, F.T

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In vitro platinum drug chemosensitivity of human cervical squamous cell carcinoma cell lines with intrinsic and acquired resistance to cisplatin von Mellish, KJ, Kelland, LR, Harrap, KR

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Biotransformation of the platinum drug JM216 following oral administration to cancer patients von RAYNAUD, F. I, MISTRY, P, DONAGHUE, A, POON, G. K, KELLAND, L. R, BARNARD, C. F. J, MURRER, B. A, HARRAP, K. R

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Genomic Imbalances Associated with Acquired Resistance to Platinum Analogues von Leyland-Jones, Brian, Kelland, Lloyd R., Harrap, Kenneth R., Hiorns, Lynne R.

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2'-Deoxycytidine kinase deficiency is a major determinant of 2-chloro-2'-deoxyadenosine resistance in lymphoid cell lines von ORR, R. M, TALBOT, D. C, WYNNE AHERNE, G, FISHER, T. C, SERAFINOWSKI, P, HARRAP, K. R

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cis-Diamminedichloroplatinum(II)-induced cell death through apoptosis in sensitive and resistant human ovarian carcinoma cell lines von ORMEROD, M. G, O'NEILL, C, ROBERTSON, D, KELLAND, L. R, HARRAP, K. R

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Synthesis and in Vitro and in Vivo Antitumor Activity of a Series of Trans Platinum Antitumor Complexes von Kelland, Lloyd R, Barnard, F. J, Evans, Iona G, Murrer, Barry A, Theobald, Brian R. C, Wyer, Sandra B, Goddard, Phyllis M, Jones, Mervyn, Valenti, Melanie

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Preclinical studies identifying carboplatin as a viable cisplatin alternative von Harrap, K.R.

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Metabolic studies of an orally active platinum anticancer drug by liquid chromatography-electrospray ionization mass spectrometry von Poon, G.K., Raynaud, F.I., Mistry, P., Odell, D.E., Kelland, L.R., Harrap, K.R., Barnard, C.F.J., Murrer, B.A.

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Biological properties of ten human ovarian carcinoma cell lines: calibration in vitro against four platinum complexes von Hills, CA, Kelland, LR, Abel, G, Siracky, J, Wilson, AP, Harrap, KR

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Tomudex (ZD1694): from concept to care, a programme in rational drug discovery von Jackman, A L, Boyle, F T, Harrap, K R

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Historical aspects of glutathione and cancer chemotherapy von Mistry, P., Harrap, K.R.

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Comparison of cellular accumulation and cytotoxicity of cisplatin with that of tetraplatin and amminedibutyratodichloro(cyclohexylamine)platinum(IV) (JM221) in human ovarian carcin... von Mistry, P, Kelland, L R, Loh, S Y, Abel, G, Murrer, B A, Harrap, K R

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