Pharmacogenomics in clinical practice and drug development von Harper, Andrew R, Topol, Eric J

Volltext

Analysis of 51 proposed hypertrophic cardiomyopathy genes from genome sequencing data in sarcomere negative cases has negligible diagnostic yield von Thomson, Kate L., Ormondroyd, Elizabeth, Harper, Andrew R., Dent, Tim, McGuire, Karen, Baksi, John, Blair, Edward, Brennan, Paul, Buchan, Rachel, Bueser, Teofila, Campbell, Carolyn, Carr-White, Gerald, Cook, Stuart, Daniels, Matthew, Deevi, Sri V.V., Goodship, Judith, Hayesmoore, Jesse B.G., Henderson, Alex, Lamb, Teresa, Prasad, Sanjay, Rayner-Matthews, Paula, Robert, Leema, Sneddon, Linda, Stark, Hannah, Walsh, Roddy, Ware, James S., Farrall, Martin, Watkins, Hugh C.

Volltext

Incremental value of left atrial booster and reservoir strain in predicting atrial fibrillation in patients with hypertrophic cardiomyopathy: a cardiovascular magnetic resonance st... von Raman, Betty, Smillie, Robert W., Mahmod, Masliza, Chan, Kenneth, Ariga, Rina, Nikolaidou, Chrysovalantou, Ormondroyd, Elizabeth, Thomson, Kate, Harper, Andrew R., Tan, Gifford, Lewandowski, Adam J., Rodriguez Bajo, Fernando, Wicks, Eleanor C., Casadei, Barbara, Watkins, Hugh, Neubauer, Stefan

Volltext

Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure von Cahill, Thomas J., Leo, Vincenzo, Kelly, Matthew, Stockenhuber, Alexander, Kennedy, Nolan W., Bao, Leyuan, Cereghetti, Grazia, Harper, Andrew R., Czibik, Gabor, Lao, Chunyan, Bellahcene, Mohamed, Steeples, Violetta, Ghaffari, Safar, Yavari, Arash, Mayer, Alice, Poulton, Joanna, Ferguson, David J.P., Scorrano, Luca, Hettiarachchi, Nishani T., Peers, Chris, Boyle, John, Hill, R. Blake, Simmons, Alison, Watkins, Hugh, Dear, T. Neil, Ashrafian, Houman

Volltext

Protective alleles and modifier variants in human health and disease von Harper, Andrew R., Nayee, Shalini, Topol, Eric J.

Volltext

Clinical information has low sensitivity for postmortem diagnosis of heart valve disease von Coffey, Sean, Harper, Andrew R, Cairns, Benjamin J, Roberts, Ian SD, Prendergast, Bernard D

Volltext

Increased impulsivity in cocaine dependent subjects independent of antisocial personality disorder and aggression von MOELLER, F. Gerard, DOUGHERTY, Donald M, BARRATT, Ernest S, ODERINDE, Victor, MATHIAS, Charles W, HARPER, R. Andrew, SWANN, Alan C

Volltext

DrugnomeAI is an ensemble machine-learning framework for predicting druggability of candidate drug targets von Raies, Arwa, Tulodziecka, Ewa, Stainer, James, Middleton, Lawrence, Dhindsa, Ryan S., Hill, Pamela, Engkvist, Ola, Harper, Andrew R., Petrovski, Slavé, Vitsios, Dimitrios

Volltext

Rare variant contribution to human disease in 281,104 UK Biobank exomes von Wang, Quanli, Dhindsa, Ryan S., Carss, Keren, Harper, Andrew R., Nag, Abhishek, Tachmazidou, Ioanna, Vitsios, Dimitrios, Deevi, Sri V. V., Mackay, Alex, Muthas, Daniel, Hühn, Michael, Monkley, Susan, Olsson, Henric, Wasilewski, Sebastian, Smith, Katherine R., March, Ruth, Platt, Adam, Haefliger, Carolina, Petrovski, Slavé

Volltext

Author Correction: DrugnomeAI is an ensemble machine-learning framework for predicting druggability of candidate drug targets von Raies, Arwa, Tulodziecka, Ewa, Stainer, James, Middleton, Lawrence, Dhindsa, Ryan S., Hill, Pamela, Engkvist, Ola, Harper, Andrew R., Petrovski, Slavé, Vitsios, Dimitrios

Volltext

Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect von Tadros, Rafik, Francis, Catherine, Xu, Xiao, Vermeer, Alexa M. C., Harper, Andrew R., Huurman, Roy, Kelu Bisabu, Ken, Walsh, Roddy, Hoorntje, Edgar T., te Rijdt, Wouter P., Buchan, Rachel J., van Velzen, Hannah G., van Slegtenhorst, Marjon A., Vermeulen, Jentien M., Offerhaus, Joost Allard, Bai, Wenjia, de Marvao, Antonio, Lahrouchi, Najim, Beekman, Leander, Karper, Jacco C., Veldink, Jan H., Kayvanpour, Elham, Pantazis, Antonis, Baksi, A. John, Whiffin, Nicola, Mazzarotto, Francesco, Sloane, Geraldine, Suzuki, Hideaki, Schneider-Luftman, Deborah, Elliott, Paul, Richard, Pascale, Ader, Flavie, Villard, Eric, Lichtner, Peter, Meitinger, Thomas, Tanck, Michael W. T., van Tintelen, J. Peter, Thain, Andrew, McCarty, David, Hegele, Robert A., Roberts, Jason D., Amyot, Julie, Dubé, Marie-Pierre, Cadrin-Tourigny, Julia, Giraldeau, Geneviève, L’Allier, Philippe L., Garceau, Patrick, Tardif, Jean-Claude, Boekholdt, S. Matthijs, Lumbers, R. Thomas, Asselbergs, Folkert W., Barton, Paul J. R., Cook, Stuart A., Prasad, Sanjay K., O’Regan, Declan P., van der Velden, Jolanda, Verweij, Karin J. H., Talajic, Mario, Lettre, Guillaume, Pinto, Yigal M., Meder, Benjamin, Charron, Philippe, de Boer, Rudolf A., Christiaans, Imke, Michels, Michelle, Wilde, Arthur A. M., Watkins, Hugh, Matthews, Paul M., Ware, James S., Bezzina, Connie R.

Volltext

Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity von Harper, Andrew R., Goel, Anuj, Grace, Christopher, Thomson, Kate L., Petersen, Steffen E., Xu, Xiao, Waring, Adam, Ormondroyd, Elizabeth, Kramer, Christopher M., Ho, Carolyn Y., Neubauer, Stefan, Tadros, Rafik, Ware, James S., Bezzina, Connie R., Farrall, Martin, Watkins, Hugh

Volltext

Distinct Subgroups in Hypertrophic Cardiomyopathy in the NHLBI HCM Registry von Neubauer, Stefan, Kolm, Paul, Ho, Carolyn Y., Kwong, Raymond Y., Desai, Milind Y., Dolman, Sarahfaye F., Appelbaum, Evan, Desvigne-Nickens, Patrice, DiMarco, John P., Friedrich, Matthias G., Geller, Nancy, Harper, Andrew R., Jarolim, Petr, Jerosch-Herold, Michael, Kim, Dong-Yun, Maron, Martin S., Schulz-Menger, Jeanette, Piechnik, Stefan K., Thomson, Kate, Zhang, Cheng, Watkins, Hugh, Weintraub, William S., Kramer, Christopher M., Mahmod, Masliza, Jacoby, Daniel, White, James, Chiribiri, Amedeo, Helms, Adam, Choudhury, Lubna, Michels, Michelle, Bradlow, William, Salerno, Michael, Heitner, Stephen, Prasad, Sanjay, Mohiddin, Saidi, Swoboda, Peter, Mahrholdt, Heiko, Bucciarelli-Ducci, Chiara, Weinsaft, Jonathan, Kim, Han, McCann, Gerry, van Rossum, Albert, Williamson, Eric, Flett, Andrew, Dawson, Dana, Mongeon, F. Pierre, Olivotto, Iacopo, Crean, Andrew, Owens, Anjali, Anderson, Lisa, Biagini, Elena, Newby, David, Berry, Colin, Kim, Bette, Larose, Eric, Abraham, Theodore, Sherrid, Mark, Nagueh, Sherif, Rimoldi, Ornella, Elstein, Eleanor, Autore, Camillo

Volltext

Behavioral impulsivity paradigms: a comparison in hospitalized adolescents with disruptive behavior disorders von Dougherty, Donald M., Bjork, James M., Andrew Harper, R., Marsh, Dawn M., Gerard Moeller, F., Mathias, Charles W., Swann, Alan C.

Volltext

Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass von Harper, Andrew R, Mayosi, Bongani M, Rodriguez, Antony, Rahman, Thahira, Hall, Darroch, Mamasoula, Chrysovalanto, Avery, Peter J, Keavney, Bernard D

Volltext

Gene-SCOUT: identifying genes with similar continuous trait fingerprints from phenome-wide association analyses von Middleton, Lawrence, Harper, Andrew R, Nag, Abhishek, Wang, Quanli, Reznichenko, Anna, Vitsios, Dimitrios, Petrovski, Slavé

Volltext

Chromospheric activity in 55 Cancri: II. Theoretical wave studies versus observations von Cuntz, Manfred, Schröder, Klaus-Peter, Fawzy, Diaa E, Ridden-Harper, Andrew R

Volltext

Disease prediction with multi-omics and biomarkers empowers case–control genetic discoveries in the UK Biobank von Garg, Manik, Karpinski, Marcin, Matelska, Dorota, Middleton, Lawrence, Burren, Oliver S., Hu, Fengyuan, Wheeler, Eleanor, Smith, Katherine R., Fabre, Margarete A., Mitchell, Jonathan, O’Neill, Amanda, Ashley, Euan A., Harper, Andrew R., Wang, Quanli, Dhindsa, Ryan S., Petrovski, Slavé, Vitsios, Dimitrios

Volltext

Rare variant associations with plasma protein levels in the UK Biobank von Dhindsa, Ryan S., Burren, Oliver S., Sun, Benjamin B., Prins, Bram P., Matelska, Dorota, Wheeler, Eleanor, Mitchell, Jonathan, Oerton, Erin, Hristova, Ventzislava A., Smith, Katherine R., Carss, Keren, Wasilewski, Sebastian, Harper, Andrew R., Paul, Dirk S., Fabre, Margarete A., Runz, Heiko, Viollet, Coralie, Challis, Benjamin, Platt, Adam, Vitsios, Dimitrios, Ashley, Euan A., Whelan, Christopher D., Pangalos, Menelas N., Wang, Quanli, Petrovski, Slavé

Volltext

Secondary findings in inherited heart conditions: a genotype-first feasibility study to assess phenotype, behavioural and psychosocial outcomes von Ormondroyd, Elizabeth, Harper, Andrew R., Thomson, Kate L., Mackley, Michael P., Martin, Jennifer, Penkett, Christopher J., Salatino, Silvia, Stark, Hannah, Stephens, Jonathan, Watkins, Hugh

Volltext