Phosphatidylethanolamine Deficiency in Mammalian Mitochondria Impairs Oxidative Phosphorylation and Alters Mitochondrial Morphology von Tasseva, Guergana, Bai, Helin Daniel, Davidescu, Magdalena, Haromy, Alois, Michelakis, Evangelos, Vance, Jean E.

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A miR-208–Mef2 Axis Drives the Decompensation of Right Ventricular Function in Pulmonary Hypertension von Paulin, Roxane, Sutendra, Gopinath, Gurtu, Vikram, Dromparis, Peter, Haromy, Alois, Provencher, Steeve, Bonnet, Sebastien, Michelakis, Evangelos D

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Attenuating Endoplasmic Reticulum Stress as a Novel Therapeutic Strategy in Pulmonary Hypertension von DROMPARIS, Peter, PAULIN, Roxane, STENSON, Trevor H, HAROMY, Alois, SUTENDRA, Gopinath, MICHELAKIS, Evangelos D

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Airway Delivery of Mesenchymal Stem Cells Prevents Arrested Alveolar Growth in Neonatal Lung Injury in Rats von van Haaften, Timothy, Byrne, Roisin, Bonnet, Sebastien, Rochefort, Gael Y, Akabutu, John, Bouchentouf, Manaf, Rey-Parra, Gloria J, Galipeau, Jacques, Haromy, Alois, Eaton, Farah, Chen, Ming, Hashimoto, Kyoko, Abley, Doris, Korbutt, Greg, Archer, Stephen L, Thebaud, Bernard

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nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted von Bonnet, Sebastien, Rochefort, Gael, Sutendra, Gopinath, Archer, Stephen L, Haromy, Alois, Webster, Linda, Hashimoto, Kyoko, Bonnet, Sandra N, Michelakis, Evangelos D

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Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility von NAGENDRAN, Jayan, ARCHER, Stephen L, LIGHT, Peter E, DYCK, Jason R. B, MICHELAKIS, Evangelos D, SOLIMAN, Daniel, GURTU, Vikram, MOUDGIL, Rohit, HAROMY, Alois, AUBIN, Chantal St, WEBSTER, Linda, REBEYKA, Ivan M, ROSS, David B

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Effect of fatty acids on human bone marrow mesenchymal stem cell energy metabolism and survival von Fillmore, Natasha, Huqi, Alda, Jaswal, Jagdip S, Mori, Jun, Paulin, Roxane, Haromy, Alois, Onay-Besikci, Arzu, Ionescu, Lavinia, Thébaud, Bernard, Michelakis, Evangelos, Lopaschuk, Gary D

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Dichloroacetate Prevents and Reverses Pulmonary Hypertension by Inducing Pulmonary Artery Smooth Muscle Cell Apoptosis von McMurtry, M Sean, Bonnet, Sebastien, Wu, Xichen, Dyck, Jason R.B, Haromy, Alois, Hashimoto, Kyoko, Michelakis, Evangelos D

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SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary... von Zhang, Yongneng, Zervopoulos, Sotirios D., Boukouris, Aristeidis E., Lorenzana-Carrillo, Maria Areli, Saleme, Bruno, Webster, Linda, Liu, Yongsheng, Haromy, Alois, Dakhili, Seyed Amirhossein Tabatabaei, Ussher, John R., Sutendra, Gopinath, Michelakis, Evangelos D.

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Loss of the fructose transporter SLC2A5 inhibits cancer cell migration von Groenendyk, Jody, Stoletov, Konstantin, Paskevicius, Tautvydas, Li, Wenjuan, Dai, Ning, Pujol, Myriam, Busaan, Erin, Ng, Hoi Hei, Boukouris, Aristeidis E., Saleme, Bruno, Haromy, Alois, Cui, Kaisa, Hu, Miao, Yan, Yanan, Zhang, Rui, Michelakis, Evangelos, Chen, Xing-Zhen, Lewis, John D., Tang, Jingfeng, Agellon, Luis B., Michalak, Marek

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A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation von Sutendra, Gopinath, Kinnaird, Adam, Dromparis, Peter, Paulin, Roxane, Stenson, Trevor H., Haromy, Alois, Hashimoto, Kyoko, Zhang, Nancy, Flaim, Eric, Michelakis, Evangelos D.

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A metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hyperten... von Sutendra, Gopinath, Dromparis, Peter, Paulin, Roxane, Zervopoulos, Sotirios, Haromy, Alois, Nagendran, Jayan, Michelakis, Evangelos D.

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Abstract 4147522: Myofibroblast transition and loss of UCP2 in a rat model and a human pulmonary hypertension cohort underline right ventricular decompensation: potential value of... von Zhang, Yongneng, Haromy, Alois, Liu, Yongsheng, Zhao, Yuan Yuan, Breuils Bonnet, Sandra, Bonnet, Sebastien, Bowles, Dawn, Sutendra, Gopinath, Michelakis, Evangelos

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MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex von Zervopoulos, Sotirios D., Boukouris, Aristeidis E., Saleme, Bruno, Haromy, Alois, Tejay, Saymon, Sutendra, Gopinath, Michelakis, Evangelos D.

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Sirtuin 3 Deficiency Is Associated with Inhibited Mitochondrial Function and Pulmonary Arterial Hypertension in Rodents and Humans von Paulin, Roxane, Dromparis, Peter, Sutendra, Gopinath, Gurtu, Vikram, Zervopoulos, Sotirios, Bowers, Lyndsay, Haromy, Alois, Webster, Linda, Provencher, Steeve, Bonnet, Sebastien, Michelakis, Evangelos D.

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Abstract 10583: A Critical Contribution of Cardiac Myofibroblasts in Rv Failure and the Role of Ucp2 Snps in the Predisposition to Rv Decompensation in Pulmonary Arterial Hypertens... von Zhang, Yongneng, Lorenzana Carrillo, Maria A, Mohseni, Mahsa, Tejay, Saymon, Liu, Yongsheng, Haromy, Alois S, Sutendra, Gopinath, Michelakis, Evangelos D

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Abstract 15760: A Critical Contribution of Cardiac Myofibroblasts and a Predictive Role of UCP2 SNPs in the RV Decompensation in Pulmonary Hypertension von Zhang, Yongneng, Lorenzana Carrillo, Maria A, Tejay, Saymon, Haromy, Alois S, Liu, Yongsheng, Zhao, Yuan Yuan, Sutendra, Gopinath, Michelakis, Evangelos D

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TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for Heart Failure von Lorenzana-Carrillo, Maria Areli, Tejay, Saymon, Nanoa, Joseph, Huang, Guocheng, Liu, Yongsheng, Haromy, Alois, Zhao, Yuan Yuan, Mendiola Pla, Michelle, Bowles, Dawn E, Kinnaird, Adam, Michelakis, Evangelos D, Sutendra, Gopinath

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A Mitochondria-K + Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth von Bonnet, Sébastien, Archer, Stephen L., Allalunis-Turner, Joan, Haromy, Alois, Beaulieu, Christian, Thompson, Richard, Lee, Christopher T., Lopaschuk, Gary D., Puttagunta, Lakshmi, Bonnet, Sandra, Harry, Gwyneth, Hashimoto, Kyoko, Porter, Christopher J., Andrade, Miguel A., Thebaud, Bernard, Michelakis, Evangelos D.

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Myocardial Functional Decline During Prolonged Ex Situ Heart Perfusion von Hatami, Sanaz, White, Christopher W., Shan, Shubham, Haromy, Alois, Qi, Xiao, Ondrus, Martin, Kinnear, Alexandra, Himmat, Sayed, Michelakis, Evangelos, Nagendran, Jayan, Freed, Darren H.

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