Targeting DNA‐Dependent Protein Kinase for Cancer Therapy von Harnor, Suzannah J., Brennan, Alfie, Cano, Céline

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Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy von Miller, Duncan C., Harnor, Suzannah J., Martin, Mathew P., Noble, Richard A., Wedge, Stephen R., Cano, Celine

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Advanced approaches of developing targeted covalent drugs von Gai, Conghao, Harnor, Suzannah J, Zhang, Shihao, Cano, Céline, Zhuang, Chunlin, Zhao, Qingjie

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Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK‑2 Selectivity of 6‑Substituted 2‑Arylaminopurines von Coxon, Christopher R, Anscombe, Elizabeth, Harnor, Suzannah J, Martin, Mathew P, Carbain, Benoit, Golding, Bernard T, Hardcastle, Ian R, Harlow, Lisa K, Korolchuk, Svitlana, Matheson, Christopher J, Newell, David R, Noble, Martin E. M, Sivaprakasam, Mangaleswaran, Tudhope, Susan J, Turner, David M, Wang, Lan Z, Wedge, Stephen R, Wong, Christopher, Griffin, Roger J, Endicott, Jane A, Cano, Céline

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Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor von Miller, Duncan C., Reuillon, Tristan, Molyneux, Lauren, Blackburn, Timothy, Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian, Harnor, Suzannah J., Heptinstall, Amy, Lochhead, Pamela, Martin, Mathew P., Martin, Nick C., Myers, Stephanie, Newell, David R., Noble, Richard A., Phillips, Nicole, Rigoreau, Laurent, Thomas, Huw, Tucker, Julie A., Wang, Lan-Zhen, Waring, Michael J., Wong, Ai-Ching, Wedge, Stephen R., Noble, Martin E. M., Cano, Celine

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Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge von Ford, Brian E., Chachra, Shruti S., Alshawi, Ahmed, Brennan, Alfie, Harnor, Suzannah, Cano, Celine, Baker, David J., Smith, David M., Fairclough, Rebecca J., Agius, Loranne

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An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase von Al-Khawaldeh, Islam, Al Yasiri, Mohammed J, Aldred, Gregory G, Basmadjian, Christine, Bordoni, Cinzia, Harnor, Suzannah J, Heptinstall, Amy B, Hobson, Stephen J, Jennings, Claire E, Khalifa, Shaimaa, Lebraud, Honorine, Martin, Mathew P, Miller, Duncan C, Shrives, Harry J, de Souza, João V, Stewart, Hannah L, Temple, Max, Thomas, Huw D, Totobenazara, Jane, Tucker, Julie A, Tudhope, Susan J, Wang, Lan Z, Bronowska, Agnieszka K, Cano, Céline, Endicott, Jane A, Golding, Bernard T, Hardcastle, Ian R, Hickson, Ian, Wedge, Stephen R, Willmore, Elaine, Noble, Martin E. M, Waring, Michael J

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The enhanced in vivo activity of the combination of a MEK and a PI3K inhibitor correlates with [18F]-FLT PET in human colorectal cancer xenograft tumour-bearing mice von Haagensen, Emma J, Thomas, Huw D, Wilson, Ian, Harnor, Suzannah J, Payne, Sara L, Rennison, Tommy, Smith, Kate M, Maxwell, Ross J, Newell, David R

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Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation von Spry, Christina, Sewell, Alan L., Hering, Yuliya, Villa, Mathew V.J., Weber, Jonas, Hobson, Stephen J., Harnor, Suzannah J., Gul, Sheraz, Marquez, Rodolfo, Saliba, Kevin J.

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Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4 von Myers, Stephanie M., Miller, Duncan C., Molyneux, Lauren, Arasta, Mercedes, Bawn, Ruth H., Blackburn, Timothy J., Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hammonds, Tim, Hardcastle, Ian R., Harnor, Suzannah J., Heptinstall, Amy B., Lochhead, Pamela A., Martin, Mathew P., Martin, Nick C., Newell, David R., Owen, Paul J., Pang, Leon C., Reuillon, Tristan, Rigoreau, Laurent J.M., Thomas, Huw D., Tucker, Julie A., Wang, Lan-Zhen, Wong, Ai-Ching, Noble, Martin E.M., Wedge, Stephen R., Cano, Celine

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2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase von Matheson, Christopher J, Coxon, Christopher R, Bayliss, Richard, Boxall, Kathy, Carbain, Benoit, Fry, Andrew M, Hardcastle, Ian R, Harnor, Suzannah J, Mas-Droux, Corine, Newell, David R, Richards, Mark W, Sivaprakasam, Mangaleswaran, Turner, David, Griffin, Roger J, Golding, Bernard T, Cano, Céline

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Concise syntheses of bridged morpholines von Zaytsev, Andrey V., Pickles, James E., Harnor, Suzannah J., Henderson, Alistair P., Alyasiri, Mohammed, Waddell, Paul G., Cano, Celine, Griffin, Roger J., Golding, Bernard T.

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Studies towards the fast and efficient synthesis of LL-Z1640-2 : synthesis of the complete LL-Z1640-2 framework von Harnor, Suzannah J

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Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyteATPhomeostasis during substrate challenge von Ford, Brian E., Chachra, Shruti S., Alshawi, Ahmed, Brennan, Alfie, Harnor, Suzannah, Cano, Celine, Baker, David J., Smith, David M., Fairclough, Rebecca J., Agius, Loranne

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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction von Chessari, Gianni, Hardcastle, Ian R, Ahn, Jong Sook, Anil, Burcu, Anscombe, Elizabeth, Bawn, Ruth H, Bevan, Luke D, Blackburn, Timothy J, Buck, Ildiko, Cano, Celine, Carbain, Benoit, Castro, Juan, Cons, Ben, Cully, Sarah J, Endicott, Jane A, Fazal, Lynsey, Golding, Bernard T, Griffin, Roger J, Haggerty, Karen, Harnor, Suzannah J, Hearn, Keisha, Hobson, Stephen, Holvey, Rhian S, Howard, Steven, Jennings, Claire E, Johnson, Christopher N, Lunec, John, Miller, Duncan C, Newell, David R, Noble, Martin E. M, Reeks, Judith, Revill, Charlotte H, Riedinger, Christiane, St. Denis, Jeffrey D, Tamanini, Emiliano, Thomas, Huw, Thompson, Neil T, Vinković, Mladen, Wedge, Stephen R, Williams, Pamela A, Wilsher, Nicola E, Zhang, Bian, Zhao, Yan

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Modulation of the DNA-Damage Response by Inhibitors of the Phosphatidylinositol 3-Kinase Related Kinase (PIKK) Family von Harnor, Suzannah, Pickles, James, Cano, Celine

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Abstract 5451: Profiling inhibitors of MDM2:p53 and MDMX:p53 in relation to MDMX protein levels von Tudhope, Sue, Zhao, Yan, Wittner, Anita, Wilmore, Elaine, Bertoli, Annalisa, Adhikari, Santosh, Harnor, Suzannah J., Bello, Fabio Del, Piergentili, Alessandro, Lunec, John, Hardcastle, Ian R., Griffin, Roger J., Golding, Bernard R., Cano, Celine, Newell, David R., Wedge, Stephen R.

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2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase† †Electronic supplementary information (ESI) available: Kinase profiling, assay details,... von Matheson, Christopher J., Coxon, Christopher R., Bayliss, Richard, Boxall, Kathy, Carbain, Benoit, Fry, Andrew M., Hardcastle, Ian R., Harnor, Suzannah J., Mas-Droux, Corine, Newell, David R., Richards, Mark W., Sivaprakasam, Mangaleswaran, Turner, David, Griffin, Roger J., Golding, Bernard T., Cano, Céline

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Synthesis of 3′-deoxy-3′-fluorothymidine (FLT) 5′-O-glucuronide: a reference standard for imaging studies with [18F]FLTDRN conceived this study; BTG, SJH and DRN wrote the manuscri... von Harnor, Suzannah J, Rennison, Tommy, Galler, Martin, Cano, Celine, Griffin, Roger J, Newell, David R, Golding, Bernard T

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Synthesis of 3′-deoxy-3′-fluorothymidine (FLT) 5′-O-glucuronide: a reference standard for imaging studies with [ 18 F]FLT von Harnor, Suzannah J., Rennison, Tommy, Galler, Martin, Cano, Celine, Griffin, Roger J., Newell, David R., Golding, Bernard T.

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