SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression von Hou, Guojun, Harley, Isaac T. W., Lu, Xiaoming, Zhou, Tian, Xu, Ning, Yao, Chao, Qin, Yuting, Ouyang, Ye, Ma, Jianyang, Zhu, Xinyi, Yu, Xiang, Xu, Hong, Dai, Dai, Ding, Huihua, Yin, Zhihua, Ye, Zhizhong, Deng, Jun, Zhou, Mi, Tang, Yuanjia, Namjou, Bahram, Guo, Ya, Weirauch, Matthew T., Kottyan, Leah C., Harley, John B., Shen, Nan

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Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies von Kelly, Jennifer A, Harley, Isaac T. W, Kaufman, Kenneth M, Langefeld, Carl D, Harley, John B

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Random forest classification to determine environmental drivers and forecast paralytic shellfish toxins in Southeast Alaska with high temporal resolution von Harley, John R., Lanphier, Kari, Kennedy, Esther, Whitehead, Chris, Bidlack, Allison

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Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity von Harley, John B., Chen, Xiaoting, Pujato, Mario, Miller, Daniel, Maddox, Avery, Forney, Carmy, Magnusen, Albert F., Lynch, Arthur, Chetal, Kashish, Yukawa, Masashi, Barski, Artem, Salomonis, Nathan, Kaufman, Kenneth M., Kottyan, Leah C., Weirauch, Matthew T.

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Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification von Munroe, Melissa E, Lu, Rufei, Zhao, Yan D, Fife, Dustin A, Robertson, Julie M, Guthridge, Joel M, Niewold, Timothy B, Tsokos, George C, Keith, Michael P, Harley, John B, James, Judith A

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Characterization of cxorf21 Provides Molecular Insight Into Female-Bias Immune Response in SLE Pathogenesis von Harris, Valerie M, Koelsch, Kristi A, Kurien, Biji T, Harley, Isaac T W, Wren, Jonathan D, Harley, John B, Scofield, R Hal

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The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α von Zhu, Shu, Pan, Wen, Song, Xinyang, Liu, Yan, Shao, Xinrui, Tang, Yuanjia, Liang, Dong, He, Dongyi, Wang, Honglin, Liu, Wenjun, Shi, Yufang, Harley, John B, Shen, Nan, Qian, Youcun

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Whole‐Exome Sequencing Reveals Overlap Between Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis and Familial Hemophagocytic Lymphohistiocytosis von Kaufman, Kenneth M., Linghu, Bolan, Szustakowski, Joseph D., Husami, Ammar, Yang, Fan, Zhang, Kejian, Filipovich, Alexandra H., Fall, Ndate, Harley, John B., Nirmala, N. R., Grom, Alexei A.

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Identification of unique microRNA signature associated with lupus nephritis von Te, Jeannie L, Dozmorov, Igor M, Guthridge, Joel M, Nguyen, Kim L, Cavett, Joshua W, Kelly, Jennifer A, Bruner, Gail R, Harley, John B, Ojwang, Joshua O

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Global discovery of lupus genetic risk variant allelic enhancer activity von Lu, Xiaoming, Chen, Xiaoting, Forney, Carmy, Donmez, Omer, Miller, Daniel, Parameswaran, Sreeja, Hong, Ted, Huang, Yongbo, Pujato, Mario, Cazares, Tareian, Miraldi, Emily R., Ray, John P., de Boer, Carl G., Harley, John B., Weirauch, Matthew T., Kottyan, Leah C.

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MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis von Pan, Wen, Zhu, Shu, Dai, Dai, Liu, Zheng, Li, Dan, Li, Bin, Gagliani, Nicola, Zheng, Yunjiang, Tang, Yuanjia, Weirauch, Matthew T., Chen, Xiaoting, Zhu, Wei, Wang, Yue, Chen, Bo, Qian, Youcun, Chen, Yingxuan, Fang, Jingyuan, Herbst, Ronald, Richman, Laura, Jallal, Bahija, Harley, John B., Flavell, Richard A., Yao, Yihong, Shen, Nan

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The effect of inversion at 8p23 on BLK association with lupus in Caucasian population von Namjou, Bahram, Ni, Yizhao, Harley, Isaac T W, Chepelev, Iouri, Cobb, Beth, Kottyan, Leah C, Gaffney, Patrick M, Guthridge, Joel M, Kaufman, Kenneth, Harley, John B

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Association between systemic lupus erythematosus and myasthenia gravis: A population-based National Study von Igoe, Ann, Merjanah, Sali, Harley, Isaac T.W., Clark, Dennis H., Sun, Celi, Kaufman, Kenneth M., Harley, John B., Kaelber, David C., Scofield, R. Hal

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Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus von Arbuckle, Melissa R, McClain, Micah T, Rubertone, Mark V, Scofield, R. Hal, Dennis, Gregory J, James, Judith A, Harley, John B

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Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility von Adrianto, Indra, Lin, Chee Paul, Hale, Jessica J, Levin, Albert M, Datta, Indrani, Parker, Ryan, Adler, Adam, Kelly, Jennifer A, Kaufman, Kenneth M, Lessard, Christopher J, Moser, Kathy L, Kimberly, Robert P, Harley, John B, Iannuzzi, Michael C, Rybicki, Benjamin A, Montgomery, Courtney G

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T-bet + CD11c + B cells are critical for antichromatin immunoglobulin G production in the development of lupus von Liu, Ya, Zhou, Shiyu, Qian, Jie, Wang, Yan, Yu, Xiang, Dai, Dai, Dai, Min, Wu, Lingling, Liao, Zhuojun, Xue, Zhixin, Wang, Jiehua, Hou, Goujun, Ma, Jianyang, Harley, John B, Tang, Yuanjia, Shen, Nan

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Identification of Four Novel Loci in Asthma in European American and African American Populations von Almoguera, Berta, Vazquez, Lyam, Mentch, Frank, Connolly, John, Pacheco, Jennifer A, Sundaresan, Agnes S, Peissig, Peggy L, Linneman, James G, McCarty, Catherine A, Crosslin, David, Carrell, David S, Lingren, Todd, Namjou-Khales, Bahram, Harley, John B, Larson, Eric, Jarvik, Gail P, Brilliant, Murray, Williams, Marc S, Kullo, Iftikhar J, Hysinger, Erik B, Sleiman, Patrick M A, Hakonarson, Hakon

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A High Prevalence of Anti-EBNA1 Heteroantibodies in Systemic Lupus Erythematosus (SLE) Supports Anti-EBNA1 as an Origin for SLE Autoantibodies von Laurynenka, Viktoryia, Ding, Lili, Kaufman, Kenneth M, James, Judith A, Harley, John B

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Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks von Pelikan, Richard C., Kelly, Jennifer A., Fu, Yao, Lareau, Caleb A., Tessneer, Kandice L., Wiley, Graham B., Wiley, Mandi M., Glenn, Stuart B., Harley, John B., Guthridge, Joel M., James, Judith A., Aryee, Martin J., Montgomery, Courtney, Gaffney, Patrick M.

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Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery von Zhou, Tian, Zhu, Xinyi, Ye, Zhizhong, Wang, Yong-Fei, Yao, Chao, Xu, Ning, Zhou, Mi, Ma, Jianyang, Qin, Yuting, Shen, Yiwei, Tang, Yuanjia, Yin, Zhihua, Xu, Hong, Zhang, Yutong, Zang, Xiaoli, Ding, Huihua, Yang, Wanling, Guo, Ya, Harley, John B., Namjou, Bahram, Kaufman, Kenneth M., Kottyan, Leah C., Weirauch, Matthew T., Hou, Guojun, Shen, Nan

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