Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762 von Chaidos, Aristeidis, Caputo, Valentina, Gouvedenou, Katerina, Liu, Binbin, Marigo, Ilaria, Chaudhry, Mohammed Suhail, Rotolo, Antonia, Tough, David F., Smithers, Nicholas N., Bassil, Anna K., Chapman, Trevor D., Harker, Nicola R., Barbash, Olena, Tummino, Peter, Al-Mahdi, Niam, Haynes, Andrea C., Cutler, Leanne, Le, BaoChau, Rahemtulla, Amin, Roberts, Irene, Kleijnen, Maurits, Witherington, Jason J., Parr, Nigel J., Prinjha, Rab K., Karadimitris, Anastasios

Volltext

HDAC3 Mediates the Inflammatory Response and LPS Tolerance in Human Monocytes and Macrophages von Ghiboub, Mohammed, Zhao, Jing, Li Yim, Andrew Y. F., Schilderink, Ronald, Verseijden, Caroline, van Hamersveld, Patricia H. P., Duarte, Jose M., Hakvoort, Theodorus B. M., Admiraal, Iris, Harker, Nicola R., Tough, David F., Henneman, Peter, de Winther, Menno P. J., de Jonge, Wouter J.

Volltext

In silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer von Quintela, Marcos, James, David W., Garcia, Jetzabel, Edwards, Kadie, Margarit, Lavinia, Das, Nagindra, Lutchman-Singh, Kerryn, Beynon, Amy L., Rioja, Inmaculada, Prinjha, Rab K., Harker, Nicola R., Gonzalez, Deyarina, Steven Conlan, R., Francis, Lewis W.

Volltext

The Epigenetic Reader Protein SP140 Regulates Dendritic Cell Activation, Maturation and Tolerogenic Potential von Ghiboub, Mohammed, Bell, Matthew, Sinkeviciute, Dovile, Prinjha, Rab K, de Winther, Menno P J, Harker, Nicola R, Tough, David F, de Jonge, Wouter J

Volltext

Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140 von Ghiboub, Mohammed, Koster, Jan, Craggs, Peter D, Li Yim, Andrew Y. F, Shillings, Anthony, Hutchinson, Sue, Bingham, Ryan P, Gatfield, Kelly, Hageman, Ishtu L, Yao, Gang, O'Keefe, Heather P, Coffin, Aaron, Patel, Amish, Sloan, Lisa A, Mitchell, Darren J, Hayhow, Thomas G, Lunven, Laurent, Watson, Robert J, Blunt, Christopher E, Harrison, Lee A, Bruton, Gordon, Kumar, Umesh, Hamer, Natalie, Spaull, John R, Zwijnenburg, Danny A, Welting, Olaf, Hakvoort, Theodorus B. M, te Velde, Anje A, van Limbergen, Johan, Henneman, Peter, Prinjha, Rab K, de Winther, Menno P. J, Harker, Nicola R, Tough, David F, de Jonge, Wouter J

Volltext

Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells von Quintela, Marcos, James, David W, Pociute, Agne, Powell, Lydia, Edwards, Kadie, Coombes, Zoe, Garcia, Jetzabel, Garton, Neil, Das, Nagindra, Lutchman-Singh, Kerryn, Margarit, Lavinia, Beynon, Amy L, Rioja, Inmaculada, Prinjha, Rab K, Harker, Nicola R, Gonzalez, Deyarina, Conlan, R Steven, Francis, Lewis W

Volltext

Selective Targeting of Epigenetic Readers and Histone Deacetylases in Autoimmune and Inflammatory Diseases: Recent Advances and Future Perspectives von Ghiboub, Mohammed, Elfiky, Ahmed M. I., de Winther, Menno P. J., Harker, Nicola R., Tough, David F., de Jonge, Wouter J.

Volltext

Pre-TCR signaling and CD8 gene bivalent chromatin resolution during thymocyte development von Harker, Nicola, Garefalaki, Anna, Menzel, Ursula, Ktistaki, Eleni, Naito, Taku, Georgopoulos, Katia, Kioussis, Dimitris

Volltext

The Relative Efficiency of Acquisition of MHC:Peptide Complexes and Cross-Presentation Depends on Dendritic Cell Type von Smyth, Lesley Ann, Harker, Nicola, Turnbull, Wayne, El-Doueik, Haytham, Klavinskis, Linda, Kioussis, Dimitris, Lombardi, Giovanna, Lechler, Robert

Volltext

996 – The Epigenetic Protein Sp140 Directs Inflammatory Activation of Macrophages in Crohn's Disease von Ghiboub, Mohammed, Harker, Nicola, Craggs, Peter D., Hutchinson, Sue, Shillings, Anthony, Henneman, Peter, Prinjha, Rab, Tough, David, de Jonge, Wouter

Volltext

Transgenic mice with hematopoietic and lymphoid specific expression of Cre von de Boer, Jasper, Williams, Adam, Skavdis, George, Harker, Nicola, Coles, Mark, Tolaini, Mauro, Norton, Trisha, Williams, Keith, Roderick, Kathleen, Potocnik, Alexandre J., Kioussis, Dimitris

Volltext

Mo1137 HDAC3 MEDIATES THE INFLAMMATORY RESPONSE AND LPS TOLERANCE IN HUMAN MONOCYTES AND MACROPHAGES von Ghiboub, Mohammed, Zhao, Jing, Yim, Andrew Y. Li, Schilderink, Ronald, Verseijden, Caroline, van Hamersveld, Patricia, Duarte, Jose M., Hakvoort, Theodorus, Admiraal, Iris, Harker, Nicola, Tough, David, Henneman, Peter, de Winther, Menno, de Jonge, Wouter

Volltext

Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems von Patel, Amisha, Harker, Nicola, Moreira-Santos, Lara, Ferreira, Manuela, Alden, Kieran, Timmis, Jon, Foster, Katie, Garefalaki, Anna, Pachnis, Panayotis, Andrews, Paul, Enomoto, Hideki, Milbrandt, Jeffrey, Pachnis, Vassilis, Coles, Mark C, Kioussis, Dimitris, Veiga-Fernandes, Henrique

Volltext

Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation von Gilan, Omer, Rioja, Inmaculada, Knezevic, Kathy, Bell, Matthew J., Yeung, Miriam M., Harker, Nicola R., Lam, Enid Y. N., Chung, Chun-wa, Bamborough, Paul, Petretich, Massimo, Urh, Marjeta, Atkinson, Stephen J., Bassil, Anna K., Roberts, Emma J., Vassiliadis, Dane, Burr, Marian L., Preston, Alex G. S., Wellaway, Christopher, Werner, Thilo, Gray, James R., Michon, Anne-Marie, Gobbetti, Thomas, Kumar, Vinod, Soden, Peter E., Haynes, Andrea, Vappiani, Johanna, Tough, David F., Taylor, Simon, Dawson, Sarah-Jane, Bantscheff, Marcus, Lindon, Matthew, Drewes, Gerard, Demont, Emmanuel H., Daniels, Danette L., Grandi, Paola, Prinjha, Rab K., Dawson, Mark A.

Volltext

Selective targeting of BD1 and BD2 of the BET proteins in cancer and immuno-inflammation von Gilan, Omer, Rioja, Inmaculada, Knezevic, Kathy, Bell, Matthew J, Yeung, Miriam M., Harker, Nicola R, Lam, Enid Y.N., Chung, Chun-wa, Bamborough, Paul, Petretich, Massimo, Urh, Marjeta, Atkinson, Stephen J, Bassil, Anna K, Roberts, Emma J, Vassiliadis, Dane, Burr, Marian L., Preston, Alex G.S, Wellaway, Christopher, Werner, Thilo, Gray, James R, Michon, Anne-Marie, Gobbetti, Thomas, Kumar, Vinod, Soden, Peter E, Haynes, Andrea, Vappiani, Johanna, Tough, David F, Taylor, Simon, Dawson, Sarah-Jane, Bantscheff, Marcus, Lindon, Matthew, Drewes, Gerard, Demont, Emmanuel H, Daniels, Danette L., Grandi, Paola, Prinjha, Rab K, Dawson, Mark A.

Volltext

Interactions with Multiple Peptide Ligands Determine the Fate of Developing Thymocytes von Williams, Owen, Tarazona, Raquel, Wack, Andreas, Harker, Nicola, Roderick, Kathleen, Kioussis, Dimitris

Volltext

The CD8α Gene Locus Is Regulated by the Ikaros Family of Proteins von Harker, Nicola, Naito, Taku, Cortes, Marta, Hostert, Arnd, Hirschberg, Sandra, Tolaini, Mauro, Roderick, Kathleen, Georgopoulos, Katia, Kioussis, Dimitris

Volltext

Position effect variegation and imprinting of transgenes in lymphocytes von Williams, Adam, Harker, Nicola, Ktistaki, Eleni, Veiga-Fernandes, Henrique, Roderick, Kathleen, Tolaini, Mauro, Norton, Trisha, Williams, Keith, Kioussis, Dimitris

Volltext

Potent Anti-Myeloma Activity Of The Novel Bromodomain Inhibitors I-BET151 and I-BET762 von Chaidos, Aristeidis, Caputo, Valentina, Marigo, Ilaria, Liu, Binbin, Chaudhry, Suhail, Goudevenou, Katerina, Rotolo, Antonia, Tough, David F, Smithers, Nicholas N, Bassil, Anna K, Chapman, Trevor D, Harker, Nicola R, Barbash, Olena, Tummino, Peter, Al-Mahdi, Niam, Haynes, Andrea C, Cutler, Leanne, Le, BaoChau, Rahemtulla, Amin, Roberts, Irene, Kleijnen, Maurits, Witherington, Jason, Parr, Nigel J, Prinjha, Rab K, Karadimitris, Anastasios

Volltext

Th Cells and Th2 Responses Can Develop in the Absence of MHC Class II-CD4 Interactions von Wack, Andreas, Corbella, Paola, Harker, Nicola, Roderick, Kathleen, Norton, Trisha, Williams, Keith, Williams, Owen, Kioussis, Dimitris

Volltext