Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity von Mobbs, Jesse I, Belousoff, Matthew J, Harikumar, Kaleeckal G, Piper, Sarah J, Xu, Xiaomeng, Furness, Sebastian G B, Venugopal, Hari, Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Thal, David M, Miller, Laurence J, Sexton, Patrick M

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Crystal structure of the Frizzled 4 receptor in a ligand-free state von Yang, Shifan, Wu, Yiran, Xu, Ting-Hai, de Waal, Parker W., He, Yuanzheng, Pu, Mengchen, Chen, Yuxiang, DeBruine, Zachary J., Zhang, Bingjie, Zaidi, Saheem A., Popov, Petr, Guo, Yu, Han, Gye Won, Lu, Yang, Suino-Powell, Kelly, Dong, Shaowei, Harikumar, Kaleeckal G., Miller, Laurence J., Katritch, Vsevolod, Xu, H. Eric, Shui, Wenqing, Stevens, Raymond C., Melcher, Karsten, Zhao, Suwen, Xu, Fei

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Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization von DeBruine, Zachary J, Ke, Jiyuan, Harikumar, Kaleeckal G, Gu, Xin, Borowsky, Peter, Williams, Bart O, Xu, Wenqing, Miller, Laurence J, Xu, H Eric, Melcher, Karsten

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Impact of secretin receptor homo-dimerization on natural ligand binding von Harikumar, Kaleeckal G., Piper, Sarah J., Christopoulos, Arthur, Wootten, Denise, Sexton, Patrick M., Miller, Laurence J.

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Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex von Ke, Jiyuan, Harikumar, Kaleeckal G, Erice, Clara, Chen, Chen, Gu, Xin, Wang, Liren, Parker, Naomi, Cheng, Zhihong, Xu, Wenqing, Williams, Bart O, Melcher, Karsten, Miller, Laurence J, Xu, H Eric

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Structure and dynamics of the active Gs-coupled human secretin receptor von Dong, Maoqing, Deganutti, Giuseppe, Piper, Sarah J., Liang, Yi-Lynn, Khoshouei, Maryam, Belousoff, Matthew J., Harikumar, Kaleeckal G., Reynolds, Christopher A., Glukhova, Alisa, Furness, Sebastian G. B., Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Sexton, Patrick M., Miller, Laurence J.

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Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling von Harikumar, Kaleeckal G, Zhao, Peishen, Cary, Brian P, Xu, Xiaomeng, Desai, Aditya J, Dong, Maoqing, Mobbs, Jesse I, Toufaily, Chirine, Furness, Sebastian G B, Christopoulos, Arthur, Belousoff, Matthew J, Wootten, Denise, Sexton, Patrick M, Miller, Laurence J

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Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor von Ward, Richard J, Pediani, John D, Harikumar, Kaleeckal G, Miller, Laurence J, Milligan, Graeme

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Environment-Sensitive Fluorescence of 7-Nitrobenz-2-oxa-1,3-diazol-4-yl (NBD)-Labeled Ligands for Serotonin Receptors von Sarkar, Parijat, Harikumar, Kaleeckal G., Rawat, Satinder S., Das, Sanjib, Chakraborty, Tushar K., Chattopadhyay, Amitabha

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Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics von Miller, Laurence J, Harikumar, Kaleeckal G, Wootten, Denise, Sexton, Patrick M

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Mechanism of Action and Structure-Activity Relationships of Tetracyclic Small Molecules Acting as Universal Positive Allosteric Modulators of the Cholecystokinin Receptor von Dengler, Daniela G, Harikumar, Kaleeckal G, Yen, Alice, Sergienko, Eduard A, Miller, Laurence J

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Transmembrane Segment IV Contributes a Functionally Important Interface for Oligomerization of the Class II G Protein-coupled Secretin Receptor von Harikumar, Kaleeckal G., Pinon, Delia I., Miller, Laurence J.

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Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery von Harikumar, Kaleeckal G, Wootten, Denise, Pinon, Delia I, Koole, Cassandra, Ball, Alicja M, Furness, Sebastian G. B, Graham, Bim, Dong, Maoqing, Christopoulos, Arthur, Miller, Laurence J, Sexton, Patrick M

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Screening for positive allosteric modulators of cholecystokinin type 1 receptor potentially useful for management of obesity von Dengler, Daniela G., Sun, Qing, Harikumar, Kaleeckal G., Miller, Laurence J., Sergienko, Eduard A.

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Differential sensitivity of types 1 and 2 cholecystokinin receptors to membrane cholesterol von Potter, Ross M., Harikumar, Kaleeckal G., Wu, S.Vincent, Miller, Laurence J.

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Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol von Harikumar, Kaleeckal G, Coudrat, Thomas, Desai, Aditya J, Dong, Maoqing, Dengler, Daniela G, Furness, Sebastian G B, Christopoulos, Arthur, Wootten, Denise, Sergienko, Eduard A, Sexton, Patrick M, Miller, Laurence J

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Structure-activity relationships of thiadiazole agonists of the human secretin receptor von Ardecky, Robert, Dengler, Daniela G., Harikumar, Kaleeckal G., Abelman, Mathew M., Zou, Jiwen, Kramer, Bryan A., Ganji, Santhi Reddy, Olson, Steve, Ly, Alina, Puvvula, Nikhil, Ma, Chen-Ting, Ramachandra, Raghuveer, Sergienko, Eduard A., Miller, Laurence J.

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Dimeric Arrangement of the Parathyroid Hormone Receptor and a Structural Mechanism for Ligand-induced Dissociation von Pioszak, Augen A., Harikumar, Kaleeckal G., Parker, Naomi R., Miller, Laurence J., Xu, H.Eric

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Single-molecule FRET imaging of GPCR dimers in living cells von Asher, Wesley B., Geggier, Peter, Holsey, Michael D., Gilmore, Grant T., Pati, Avik K., Meszaros, Jozsef, Terry, Daniel S., Mathiasen, Signe, Kaliszewski, Megan J., McCauley, Mitchell D., Govindaraju, Alekhya, Zhou, Zhou, Harikumar, Kaleeckal G., Jaqaman, Khuloud, Miller, Laurence J., Smith, Adam W., Blanchard, Scott C., Javitch, Jonathan A.

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Signaling Modification by GPCR Heteromer and Its Implication on X-Linked Nephrogenic Diabetes Insipidus von Ng, Hans K H, Harikumar, Kaleeckal G, Miller, Laurence J, Chow, Billy K C

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