Targeting bacterial energetics to produce new antimicrobials von Hards, Kiel, Cook, Gregory M.

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The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB von Safarian, Schara, Opel-Reading, Helen K., Wu, Di, Mehdipour, Ahmad R., Hards, Kiel, Harold, Liam K., Radloff, Melanie, Stewart, Ian, Welsch, Sonja, Hummer, Gerhard, Cook, Gregory M., Krause, Kurt L., Michel, Hartmut

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A soil actinobacterium scavenges atmospheric H2 using two membrane-associated, oxygen-dependent [NiFe] hydrogenases von Greening, Chris, Berney, Michael, Hards, Kiel, Cook, Gregory M, Conrad, Ralf

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Ionophoric effects of the antitubercular drug bedaquiline von Hards, Kiel, McMillan, Duncan G. G., Schurig-Briccio, Lici A., Gennis, Robert B., Lilld, Holger, Bald, Dirk, Cook, Gregory M.

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Rate-limiting transport of positively charged arginine residues through the Sec-machinery is integral to the mechanism of protein secretion von Allen, William J, Corey, Robin A, Watkins, Daniel W, Oliveira, A Sofia F, Hards, Kiel, Cook, Gregory M, Collinson, Ian

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Deciphering functional redundancy and energetics of malate oxidation in mycobacteria von Harold, Liam K., Jinich, Adrian, Hards, Kiel, Cordeiro, Alexandra, Keighley, Laura M., Cross, Alec, McNeil, Matthew B., Rhee, Kyu, Cook, Gregory M.

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Persistence of the dominant soil phylum Acidobacteria by trace gas scavenging von Greening, Chris, Carere, Carlo R, Rushton-Green, Rowena, Harold, Liam K, Hards, Kiel, Taylor, Matthew C, Morales, Sergio E, Stott, Matthew B, Cook, Gregory M

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Energetics of Respiration and Oxidative Phosphorylation in Mycobacteria von Cook, Gregory M, Hards, Kiel, Vilchèze, Catherine, Hartman, Travis, Berney, Michael

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Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering von Lee, Brendon M., Harold, Liam K., Almeida, Deepak V., Afriat-Jurnou, Livnat, Aung, Htin Lin, Forde, Brian M., Hards, Kiel, Pidot, Sacha J., Ahmed, F. Hafna, Mohamed, A. Elaaf, Taylor, Matthew C., West, Nicholas P., Stinear, Timothy P., Greening, Chris, Beatson, Scott A., Nuermberger, Eric L., Cook, Gregory M., Jackson, Colin J.

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Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant Mycobacterium tuberculosis von Lee, Bei Shi, Hards, Kiel, Engelhart, Curtis A, Hasenoehrl, Erik J, Kalia, Nitin P, Mackenzie, Jared S, Sviriaeva, Ekaterina, Chong, Shi Min Sherilyn, Manimekalai, Malathy Sony S, Koh, Vanessa H, Chan, John, Xu, Jiayong, Alonso, Sylvie, Miller, Marvin J, Steyn, Adrie J C, Grüber, Gerhard, Schnappinger, Dirk, Berney, Michael, Cook, Gregory M, Moraski, Garrett C, Pethe, Kevin

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M. tuberculosis relies on trace oxygen to maintain energy homeostasis and survive in hypoxic environments von Kalia, Nitin Pal, Singh, Samsher, Hards, Kiel, Cheung, Chen-Yi, Sviriaeva, Ekaterina, Banaei-Esfahani, Amir, Aebersold, Ruedi, Berney, Michael, Cook, Gregory M., Pethe, Kevin

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Atmospheric hydrogen scavenging: from enzymes to ecosystems von Greening, Chris, Constant, Philippe, Hards, Kiel, Morales, Sergio E, Oakeshott, John G, Russell, Robyn J, Taylor, Matthew C, Berney, Michael, Conrad, Ralf, Cook, Gregory M

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Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis von Saw, Wuan-Geok, Wu, Mu-Lu, Ragunathan, Priya, Biuković, Goran, Lau, Aik-Meng, Shin, Joon, Harikishore, Amaravadhi, Cheung, Chen-Yi, Hards, Kiel, Sarathy, Jickky Palmae, Bates, Roderick W., Cook, Gregory M., Dick, Thomas, Grüber, Gerhard

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Soil Candidate Phyla Radiation Bacteria Encode Components of Aerobic Metabolism and Co-occur with Nanoarchaea in the Rare Biosphere of Rhizosphere Grassland Communities von Nicolas, Alexa M., Jaffe, Alexander L., Nuccio, Erin E., Taga, Michiko E., Firestone, Mary K., Banfield, Jillian F.

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An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis von Hards, Kiel, Cheung, Chen-Yi, Waller, Natalie, Adolph, Cara, Keighley, Laura, Tee, Zhi Shean, Harold, Liam K., Menorca, Ayana, Bujaroski, Richard S., Buckley, Benjamin J., Tyndall, Joel D. A., McNeil, Matthew B., Rhee, Kyu Y., Opel-Reading, Helen K., Krause, Kurt, Preiss, Laura, Langer, Julian D., Meier, Thomas, Hasenoehrl, Erik J., Berney, Michael, Kelso, Michael J., Cook, Gregory M.

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Alkyltriphenylphosphonium turns naphthoquinoneimidazoles into potent membrane depolarizers against mycobacteria von Fridianto, Kevin Timothy, Gunawan, Gregory Adrian, Hards, Kiel, Sarathy, Jickky Palmae, Cook, Gregory M, Dick, Thomas, Go, Mei-Lin, Lam, Yulin

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Growth on Formic Acid Is Dependent on Intracellular pH Homeostasis for the Thermoacidophilic Methanotroph Methylacidiphilum sp. RTK17.1 von Carere, Carlo R., Hards, Kiel, Wigley, Kathryn, Carman, Luke, Houghton, Karen M., Cook, Gregory M., Stott, Matthew B.

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Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2 von Harbison-Price, Nichaela, Ferguson, Scott A., Heikal, Adam, Taiaroa, George, Hards, Kiel, Nakatani, Yoshio, Rennison, David, Brimble, Margaret A., El-Deeb, Ibrahim M., Bohlmann, Lisa, McDevitt, Christopher A., von Itzstein, Mark, Walker, Mark J., Cook, Gregory M.

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Essentiality of succinate dehydrogenase in Mycobacterium smegmatis and its role in the generation of the membrane potential under hypoxia von Pecsi, Ildiko, Hards, Kiel, Ekanayaka, Nandula, Berney, Michael, Hartman, Travis, Jacobs, Jr, William R, Cook, Gregory M

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Synthesis and Investigation of Phthalazinones as Antitubercular Agents von Santoso, Kristiana T., Cheung, Chen‐Yi, Hards, Kiel, Cook, Gregory M., Stocker, Bridget L., Timmer, Mattie S. M.

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