TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis von Cignarella, Francesca, Filipello, Fabia, Bollman, Bryan, Cantoni, Claudia, Locca, Alberto, Mikesell, Robert, Manis, Melissa, Ibrahim, Adiljan, Deng, Li, Benitez, Bruno A., Cruchaga, Carlos, Licastro, Danilo, Mihindukulasuriya, Kathie, Harari, Oscar, Buckland, Michael, Holtzman, David M., Rosenthal, Arnon, Schwabe, Tina, Tassi, Ilaria, Piccio, Laura

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Coding variants in TREM2 increase risk for Alzheimer's disease von Jin, Sheng Chih, Benitez, Bruno A, Karch, Celeste M, Cooper, Breanna, Skorupa, Tara, Carrell, David, Norton, Joanne B, Hsu, Simon, Harari, Oscar, Cai, Yefei, Bertelsen, Sarah, Goate, Alison M, Cruchaga, Carlos

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Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders von Yang, Chengran, Farias, Fabiana H. G., Ibanez, Laura, Suhy, Adam, Sadler, Brooke, Fernandez, Maria Victoria, Wang, Fengxian, Bradley, Joseph L., Eiffert, Brett, Bahena, Jorge A., Budde, John P., Li, Zeran, Dube, Umber, Sung, Yun Ju, Mihindukulasuriya, Kathie A., Morris, John C., Fagan, Anne M., Perrin, Richard J., Benitez, Bruno A., Rhinn, Herve, Harari, Oscar, Cruchaga, Carlos

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A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease von Huang, Kuan-lin, Marcora, Edoardo, Pimenova, Anna A, Di Narzo, Antonio F, Kapoor, Manav, Jin, Sheng Chih, Harari, Oscar, Bertelsen, Sarah, Fairfax, Benjamin P, Czajkowski, Jake, Chouraki, Vincent, Grenier-Boley, Benjamin, Bellenguez, Céline, Deming, Yuetiva, McKenzie, Andrew, Raj, Towfique, Renton, Alan E, Budde, John, Smith, Albert, Fitzpatrick, Annette, Bis, Joshua C, DeStefano, Anita, Adams, Hieab H H, Ikram, M Arfan, van der Lee, Sven, Del-Aguila, Jorge L, Fernandez, Maria Victoria, Ibañez, Laura, Sims, Rebecca, Escott-Price, Valentina, Mayeux, Richard, Haines, Jonathan L, Farrer, Lindsay A, Pericak-Vance, Margaret A, Lambert, Jean Charles, van Duijn, Cornelia, Launer, Lenore, Seshadri, Sudha, Williams, Julie, Amouyel, Philippe, Schellenberg, Gerard D, Zhang, Bin, Borecki, Ingrid, Kauwe, John S K, Cruchaga, Carlos, Hao, Ke, Goate, Alison M

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A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain von Del-Aguila, Jorge L, Li, Zeran, Dube, Umber, Mihindukulasuriya, Kathie A, Budde, John P, Fernandez, Maria Victoria, Ibanez, Laura, Bradley, Joseph, Wang, Fengxian, Bergmann, Kristy, Davenport, Richard, Morris, John C, Holtzman, David M, Perrin, Richard J, Benitez, Bruno A, Dougherty, Joseph, Cruchaga, Carlos, Harari, Oscar

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Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes von Yang, Chengran, Fagan, Anne M, Perrin, Richard J, Rhinn, Herve, Harari, Oscar, Cruchaga, Carlos

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Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers von Brase, Logan, You, Shih-Feng, D’Oliveira Albanus, Ricardo, Del-Aguila, Jorge L., Dai, Yaoyi, Novotny, Brenna C., Soriano-Tarraga, Carolina, Dykstra, Taitea, Fernandez, Maria Victoria, Budde, John P., Bergmann, Kristy, Morris, John C., Bateman, Randall J., Perrin, Richard J., McDade, Eric, Xiong, Chengjie, Goate, Alison M., Farlow, Martin, Sutherland, Greg T., Kipnis, Jonathan, Karch, Celeste M., Benitez, Bruno A., Harari, Oscar

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TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers von Del-Aguila, Jorge L, Benitez, Bruno A, Li, Zeran, Dube, Umber, Mihindukulasuriya, Kathie A, Budde, John P, Farias, Fabiana H G, Fernández, Maria Victoria, Ibanez, Laura, Jiang, Shan, Perrin, Richard J, Cairns, Nigel J, Morris, John C, Harari, Oscar, Cruchaga, Carlos

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Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer's disease von Eteleeb, Abdallah M, Novotny, Brenna C, Tarraga, Carolina Soriano, Sohn, Christopher, Dhungel, Eliza, Brase, Logan, Nallapu, Aasritha, Buss, Jared, Farias, Fabiana, Bergmann, Kristy, Bradley, Joseph, Norton, Joanne, Gentsch, Jen, Wang, Fengxian, Davis, Albert A, Morris, John C, Karch, Celeste M, Perrin, Richard J, Benitez, Bruno A, Harari, Oscar

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Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation von Kauwe, John S K, Bailey, Matthew H, Ridge, Perry G, Perry, Rachel, Wadsworth, Mark E, Hoyt, Kaitlyn L, Staley, Lyndsay A, Karch, Celeste M, Harari, Oscar, Cruchaga, Carlos, Ainscough, Benjamin J, Bales, Kelly, Pickering, Eve H, Bertelsen, Sarah, Fagan, Anne M, Holtzman, David M, Morris, John C, Goate, Alison M

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Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration von Mahali, Sidhartha, Martinez, Rita, King, Melvin, Verbeck, Anthony, Harari, Oscar, Benitez, Bruno A., Horie, Kanta, Sato, Chihiro, Temple, Sally, Karch, Celeste M.

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Weakly activated core neuroinflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer's disease von Li, Fuhai, Eteleeb, Abdallah M, Buchser, William, Sohn, Christopher, Wang, Guoqiao, Xiong, Chengjie, Payne, Philip R, McDade, Eric, Karch, Celeste M, Harari, Oscar, Cruchaga, Carlos

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Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels von Ibanez, Laura, Dube, Umber, Saef, Benjamin, Budde, John, Black, Kathleen, Medvedeva, Alexandra, Del-Aguila, Jorge L, Davis, Albert A, Perlmutter, Joel S, Harari, Oscar, Benitez, Bruno A, Cruchaga, Carlos

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Phosphorylated Tau-Aβ42 Ratio as a Continuous Trait for Biomarker Discovery for Early-Stage Alzheimer’s Disease in Multiplex Immunoassay Panels of Cerebrospinal Fluid von Harari, Oscar, Cruchaga, Carlos, Kauwe, John S.K, Ainscough, Benjamin J, Bales, Kelly, Pickering, Eve H, Bertelsen, Sarah, Fagan, Anne M, Holtzman, David M, Morris, John C, Goate, Alison M

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Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains von Bigley, Tarin M, Xiong, Monica, Ali, Muhammad, Chen, Yun, Wang, Chao, Serrano, Javier Remolina, Eteleeb, Abdallah, Harari, Oscar, Yang, Liping, Patel, Swapneel J, Cruchaga, Carlos, Yokoyama, Wayne M, Holtzman, David M

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Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease von Fernández, Maria Victoria, Kim, Jong Hun, Budde, John P, Black, Kathleen, Medvedeva, Alexandra, Saef, Ben, Deming, Yuetiva, Del-Aguila, Jorge, Ibañez, Laura, Dube, Umber, Harari, Oscar, Norton, Joanne, Chasse, Rachel, Morris, John C, Goate, Alison, Cruchaga, Carlos

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The impact of multi-omics in medicine von Wang, Linghua, Qu, Jing, Harari, Oscar, Boddey, Justin A., Wang, Zhang, Linna-Kuosmanen, Suvi

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Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure von Li, Zeran, Del-Aguila, Jorge L, Dube, Umber, Budde, John, Martinez, Rita, Black, Kathleen, Xiao, Qingli, Cairns, Nigel J, Dougherty, Joseph D, Lee, Jin-Moo, Morris, John C, Bateman, Randall J, Karch, Celeste M, Cruchaga, Carlos, Harari, Oscar

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Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience von Ridge, Perry G, Karch, Celeste M, Hsu, Simon, Arano, Ivan, Teerlink, Craig C, Ebbert, Mark T W, Gonzalez Murcia, Josue D, Farnham, James M, Damato, Anna R, Allen, Mariet, Wang, Xue, Harari, Oscar, Fernandez, Victoria M, Guerreiro, Rita, Bras, Jose, Hardy, John, Munger, Ronald, Norton, Maria, Sassi, Celeste, Singleton, Andrew, Younkin, Steven G, Dickson, Dennis W, Golde, Todd E, Price, Nathan D, Ertekin-Taner, Nilüfer, Cruchaga, Carlos, Goate, Alison M, Corcoran, Christopher, Tschanz, JoAnn, Cannon-Albright, Lisa A, Kauwe, John S K

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A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks von Kapoor, Manav, Wang, Jen-Chyong, Wetherill, Leah, Le, Nhung, Bertelsen, Sarah, Hinrichs, Anthony L., Budde, John, Agrawal, Arpana, Bucholz, Kathleen, Dick, Danielle, Harari, Oscar, Hesselbrock, Victor, Kramer, John, Nurnberger, John I., Rice, John, Saccone, Nancy, Schuckit, Marc, Tischfield, Jay, Porjesz, Bernice, Edenberg, Howard J., Bierut, Laura, Foroud, Tatiana, Goate, Alison

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