Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms von Lundberg, Pontus, Karow, Axel, Nienhold, Ronny, Looser, Renate, Hao-Shen, Hui, Nissen, Ina, Girsberger, Sabine, Lehmann, Thomas, Passweg, Jakob, Stern, Martin, Beisel, Christian, Kralovics, Robert, Skoda, Radek C.

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Impact of Clonal Architecture on Clinical Course and Prognosis in Patients With Myeloproliferative Neoplasms von Luque Paz, Damien, Bader, Michael S., Nienhold, Ronny, Rai, Shivam, Almeida Fonseca, Tiago, Stetka, Jan, Hao‐Shen, Hui, Mild‐Schneider, Gabriele, Passweg, Jakob R., Skoda, Radek C.

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Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm von Rai, Shivam, Grockowiak, Elodie, Hansen, Nils, Luque Paz, Damien, Stoll, Cedric B., Hao-Shen, Hui, Mild-Schneider, Gabriele, Dirnhofer, Stefan, Farady, Christopher J., Méndez-Ferrer, Simón, Skoda, Radek C.

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Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo von Tiedt, Ralph, Schomber, Tibor, Hao-Shen, Hui, Skoda, Radek C.

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JAK2-V617F and interferon-α induce megakaryocyte-biased stem cells characterized by decreased long-term functionality von Rao, Tata Nageswara, Hansen, Nils, Stetka, Jan, Luque Paz, Damien, Kalmer, Milena, Hilfiker, Julian, Endele, Max, Ahmed, Nouraiz, Kubovcakova, Lucia, Rybarikova, Margareta, Hao-Shen, Hui, Geier, Florian, Beisel, Christian, Dirnhofer, Stefan, Schroeder, Timm, Brümmendorf, Tim H., Wolf, Dominik, Koschmieder, Steffen, Skoda, Radek C.

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Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms von Schaub, Franz X., Looser, Renate, Li, Sai, Hao-Shen, Hui, Lehmann, Thomas, Tichelli, Andre, Skoda, Radek C.

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Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F von Lundberg, Pontus, Takizawa, Hitoshi, Kubovcakova, Lucia, Guo, Guoji, Hao-Shen, Hui, Dirnhofer, Stephan, Orkin, Stuart H, Manz, Markus G, Skoda, Radek C

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Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice von Tiedt, Ralph, Hao-Shen, Hui, Sobas, Marta A., Looser, Renate, Dirnhofer, Stephan, Schwaller, Jürg, Skoda, Radek C.

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Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPN von Grisouard, Jean, Shimizu, Takafumi, Duek, Adrian, Kubovcakova, Lucia, Hao-Shen, Hui, Dirnhofer, Stephan, Skoda, Radek C.

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The allele burden of JAK2 mutations remains stable over several years in patients with myeloproliferative disorders von Theocharides, Alexandre, Passweg, Jakob R, Medinger, Michael, Looser, Renate, Li, Sai, Hao-Shen, Hui, Buser, Andreas S, Gratwohl, Alois, Tichelli, Andre, Skoda, Radek C

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Selective deletion of Jak2 in adult mouse hematopoietic cells leads to lethal anemia and thrombocytopenia von Grisouard, Jean, Hao-Shen, Hui, Dirnhofer, Stephan, Wagner, Kay-Uwe, Skoda, Radek C

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Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F–driven mouse model of MPNs von Duek, Adrian, Lundberg, Pontus, Shimizu, Takafumi, Grisouard, Jean, Karow, Axel, Kubovcakova, Lucia, Hao-Shen, Hui, Dirnhofer, Stephan, Skoda, Radek C.

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Clonal analysis of deletions on chromosome 20q and JAK2-V617F in MPD suggests that del20q acts independently and is not one of the predisposing mutations for JAK2-V617F von Schaub, Franz X., Jäger, Roland, Looser, Renate, Hao-Shen, Hui, Hermouet, Sylvie, Girodon, François, Tichelli, Andre, Gisslinger, Heinz, Kralovics, Robert, Skoda, Radek C.

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Complex subclone structure that responds differentially to therapy in a patient with essential thrombocythemia and chronic myeloid leukemia von Grisouard, Jean, Ojeda-Uribe, Mario, Looser, Renate, Hao-Shen, Hui, Lundberg, Pontus, Duek, Adrian, Jeandidier, Eric, Karow, Axel, Skoda, Radek C.

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Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mp1 in platelets and terminally differentiated megakaryocytes von TIEDT, Ralph, COERS, Jörn, SKODA, Radek C, ZIEGLER, Sandra, WIESTNER, Adrian, HUI, Hao-Shen, BORNMANN, Caroline, SCHENKEL, Johannes, KARAKHANOVA, Svetlana, DE SAUVAGE, Frederic J, JACKSON, Carl W

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Transition to homozygosity does not appear to provide a clonal advantage to hematopoietic progenitors carrying mutations in TET2 von Schaub, Franz X., Lehmann, Thomas, Looser, Renate, Hao-Shen, Hui, Tichelli, Andre, Skoda, Radek C.

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Normal erythropoiesis but severe polyposis and bleeding anemia in Smad4-deficient mice von Pan, Dejing, Schomber, Tibor, Kalberer, Christian P., Terracciano, Luigi M., Hafen, Katrin, Krenger, Werner, Hao-Shen, Hui, Deng, Chuxia, Skoda, Radek C.

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Disrupting the Socs2-Mediated Negative Feedback to JAK-STAT Signaling Boosts Molecular Responses Induced By Interferon-α in a Mouse Model of Myeloproliferative Neoplasms von Usart, Marc, Stoll, Cédric B., Karjalainen, Riikka, Hao-Shen, Hui, Skoda, Radek C.

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Cellular Barcoding of JAK2-V617F Hematopoietic Stem Cells Reveals No Substantial Preferences in the Contribution of Individual Stem Cell Clones to Erythroid Versus Megakaryocytic L... von Usart, Marc, Almeida, Tiago, Roux, Julien, El Taher, Athimed, Karjalainen, Riikka, Kimmerlin, Quentin, Rai, Shivam, Hao-Shen, Hui, Skoda, Radek C.

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Zinpentraxin Alfa Reduces Myelofibrosis in a JAK2-V617F Mouse Model of Myeloproliferative Neoplasms von Rai, Shivam, Hao-Shen, Hui, Dirnhofer, Stefan, Roux, Julien, Yadav, Rajbharan, Pfeiffer, Anamarija, Vowinckel, Jakob, Arjomandi, Audrey, Higgins, Brian, Han, Lyrialle, Trunzer, Kerstin, Lundberg, Pontus, Skoda, Radek C.

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