Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer von Hao, Huai-Xiang, Jiang, Xiaomo, Cong, Feng

Volltext

Infigratinib Mediates Vascular Normalization, Impairs Metastasis, and Improves Chemotherapy in Hepatocellular Carcinoma von Huynh, Hung, Lee, Liek Yeow, Goh, Kah Yong, Ong, Richard, Hao, Huai‐Xiang, Huang, Alan, Wang, Youzhen, Graus Porta, Diana, Chow, Pierce, Chung, Alexander

Volltext

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases von Chen, Ying-Nan P., LaMarche, Matthew J., Chan, Ho Man, Fekkes, Peter, Garcia-Fortanet, Jorge, Acker, Michael G., Antonakos, Brandon, Chen, Christine Hiu-Tung, Chen, Zhouliang, Cooke, Vesselina G., Dobson, Jason R., Deng, Zhan, Fei, Feng, Firestone, Brant, Fodor, Michelle, Fridrich, Cary, Gao, Hui, Grunenfelder, Denise, Hao, Huai-Xiang, Jacob, Jaison, Ho, Samuel, Hsiao, Kathy, Kang, Zhao B., Karki, Rajesh, Kato, Mitsunori, Larrow, Jay, La Bonte, Laura R., Lenoir, Francois, Liu, Gang, Liu, Shumei, Majumdar, Dyuti, Meyer, Matthew J., Palermo, Mark, Perez, Lawrence, Pu, Minying, Price, Edmund, Quinn, Christopher, Shakya, Subarna, Shultz, Michael D., Slisz, Joanna, Venkatesan, Kavitha, Wang, Ping, Warmuth, Markus, Williams, Sarah, Yang, Guizhi, Yuan, Jing, Zhang, Ji-Hu, Zhu, Ping, Ramsey, Timothy, Keen, Nicholas J., Sellers, William R., Stams, Travis, Fortin, Pascal D.

Volltext

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma von Jiang, Xiaomo, Hao, Huai-Xiang, Growney, Joseph D., Woolfenden, Steve, Bottiglio, Cindy, Ng, Nicholas, Lu, Bo, Hsieh, Mindy H., Bagdasarian, Linda, Meyer, Ronald, Smith, Timothy R., Avello, Monika, Charlat, Olga, Xie, Yang, Porter, Jeffery A., Pan, Shifeng, Liu, Jun, McLaughlin, Margaret E., Cong, Feng

Volltext

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma von Hao, Huai-Xiang, Khalimonchuk, Oleh, Schraders, Margit, Dephoure, Noah, Bayley, Jean-Pierre, Kunst, Henricus, Devilee, Peter, Cremers, Cor W.R.J, Schiffman, Joshua D, Bentz, Brandon G, Gygi, Steven P, Winge, Dennis R, Kremer, Hannie, Rutter, Jared

Volltext

SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms von Wang, Ye, Mohseni, Morvarid, Grauel, Angelo, Diez, Javier Estrada, Guan, Wei, Liang, Simon, Choi, Jiyoung Elizabeth, Pu, Minying, Chen, Dongshu, Laszewski, Tyler, Schwartz, Stephanie, Gu, Jane, Mansur, Leandra, Burks, Tyler, Brodeur, Lauren, Velazquez, Roberto, Kovats, Steve, Pant, Bhavesh, Buruzula, Giri, Deng, Emily, Chen, Julie T., Sari-Sarraf, Farid, Dornelas, Christina, Varadarajan, Malini, Yu, Haiyan, Liu, Chen, Lim, Joanne, Hao, Huai-Xiang, Jiang, Xiaomo, Malamas, Anthony, LaMarche, Matthew J., Geyer, Felipe Correa, McLaughlin, Margaret, Costa, Carlotta, Wagner, Joel, Ruddy, David, Jayaraman, Pushpa, Kirkpatrick, Nathaniel D., Zhang, Pu, Iartchouk, Oleg, Aardalen, Kimberly, Cremasco, Viviana, Dranoff, Glenn, Engelman, Jeffrey A., Silver, Serena, Wang, Hongyun, Hastings, William D., Goldoni, Silvia

Volltext

FGF401 and vinorelbine synergistically mediate antitumor activity and vascular normalization in FGF19-dependent hepatocellular carcinoma von Huynh, Hung, Prawira, Aldo, Le, Thi Bich Uyen, Vu, Thanh Chung, Hao, Huai-Xiang, Huang, Alan, Wang, Youzhen, Porta, Diana Graus

Volltext

Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus von Huynh, Hung, Hao, Huai-Xiang, Chan, Stephen L, Chen, David, Ong, Richard, Soo, Khee Chee, Pochanard, Panisa, Yang, David, Ruddy, David, Liu, Manway, Derti, Adnan, Balak, Marissa N, Palmer, Michael R, Wang, Yan, Lee, Benjamin H, Sellami, Dalila, Zhu, Andrew X, Schlegel, Robert, Huang, Alan

Volltext

A phase 1b study of the MET inhibitor capmatinib combined with cetuximab in patients with MET-positive colorectal cancer who had progressed following anti-EGFR monoclonal antibody... von Delord, Jean-Pierre, Argilés, Guillem, Fayette, Jerôme, Wirth, Lori, Kasper, Stefan, Siena, Salvatore, Mesia, Ricard, Berardi, Rossana, Cervantes, Andrés, Dekervel, Jeroen, Zhao, Sylvia, Sun, Yongjian, Hao, Huai-Xiang, Tiedt, Ralph, Vicente, Sergio, Myers, Andrea, Siu, Lillian L.

Volltext

Differential responses of MET activations to MET kinase inhibitor and neutralizing antibody von Kou, Jianqun, Musich, Phillip R, Staal, Ben, Kang, Liang, Qin, Yuan, Yao, Zhi Q, Zhang, Boheng, Wu, Weizhong, Tam, Angela, Huang, Alan, Hao, Huai-Xiang, Vande Woude, George F, Xie, Qian

Volltext

Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling von Liu, Chen, Lu, Hengyu, Wang, Hongyun, Loo, Alice, Zhang, Xiamei, Yang, Guizhi, Kowal, Colleen, Delach, Scott, Wang, Ye, Goldoni, Silvia, Hastings, William D, Wong, Karrie, Gao, Hui, Meyer, Matthew J, Moody, Susan E, LaMarche, Matthew J, Engelman, Jeffrey A, Williams, Juliet A, Hammerman, Peter S, Abrams, Tinya J, Mohseni, Morvarid, Caponigro, Giordano, Hao, Huai-Xiang

Volltext

Capmatinib (INC280) Is Active Against Models of Non-Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation von Baltschukat, Sabrina, Engstler, Barbara Schacher, Huang, Alan, Hao, Huai-Xiang, Tam, Angela, Wang, Hui Qin, Liang, Jinsheng, DiMare, Matthew T, Bhang, Hyo-Eun Carrie, Wang, Youzhen, Furet, Pascal, Sellers, William R, Hofmann, Francesco, Schoepfer, Joseph, Tiedt, Ralph

Volltext

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner von Hao, Huai-Xiang, Xie, Yang, Zhang, Yue, Charlat, Olga, Oster, Emma, Avello, Monika, Lei, Hong, Mickanin, Craig, Liu, Dong, Ruffner, Heinz, Mao, Xiaohong, Ma, Qicheng, Zamponi, Raffaella, Bouwmeester, Tewis, Finan, Peter M., Kirschner, Marc W., Porter, Jeffery A., Serluca, Fabrizio C., Cong, Feng

Volltext

SHP2 Inhibition Overcomes RTK-Mediated Pathway Reactivation in KRAS-Mutant Tumors Treated with MEK Inhibitors von Lu, Hengyu, Liu, Chen, Velazquez, Roberto, Wang, Hongyun, Dunkl, Lukas Manuel, Kazic-Legueux, Malika, Haberkorn, Anne, Billy, Eric, Manchado, Eusebio, Brachmann, Saskia M, Moody, Susan E, Engelman, Jeffrey A, Hammerman, Peter S, Caponigro, Giordano, Mohseni, Morvarid, Hao, Huai-Xiang

Volltext

The role of PAS kinase in regulating energy metabolism von Hao, Huai‐Xiang, Rutter, Jared

Volltext

Dual Allosteric Inhibition of SHP2 Phosphatase von Fodor, Michelle, Price, Edmund, Wang, Ping, Lu, Hengyu, Argintaru, Andreea, Chen, Zhouliang, Glick, Meir, Hao, Huai-Xiang, Kato, Mitsunori, Koenig, Robert, LaRochelle, Jonathan R, Liu, Gang, McNeill, Eric, Majumdar, Dyuti, Nishiguchi, Gisele A, Perez, Lawrence B, Paris, Gregory, Quinn, Christopher M, Ramsey, Timothy, Sendzik, Martin, Shultz, Michael David, Williams, Sarah L, Stams, Travis, Blacklow, Stephen C, Acker, Michael G, LaMarche, Matthew J

Volltext

PAS kinase is required for normal cellular energy balance von Hao, Huai-Xiang, Cardon, Caleb M, Swiatek, Wojtek, Cooksey, Robert C, Smith, Tammy L, Wilde, James, Boudina, Sihem, Abel, E. Dale, McClain, Donald A, Rutter, Jared

Volltext

Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization von An, Rong, da Silva Xavier, Gabriela, Semplici, Francesca, Vakhshouri, Saharnaz, Hao, Huai-Xiang, Rutter, Jared, Pagano, Mario A., Meggio, Flavio, Pinna, Lorenzo A., Rutter, Guy A.

Volltext

Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers von Hao, Huai-Xiang, Wang, Hongyun, Liu, Chen, Kovats, Steven, Velazquez, Roberto, Lu, Hengyu, Pant, Bhavesh, Shirley, Matthew, Meyer, Matthew J, Pu, Minying, Lim, Joanne, Fleming, Michael, Alexander, LeighAnn, Farsidjani, Ali, LaMarche, Matthew J, Moody, Susan, Silver, Serena J, Caponigro, Giordano, Stuart, Darrin D, Abrams, Tinya J, Hammerman, Peter S, Williams, Juliet, Engelman, Jeffrey A, Goldoni, Silvia, Mohseni, Morvarid

Volltext

Revealing human disease genes through analysis of the yeast mitochondrial proteome von Hao, Huai-Xiang, Rutter, Jared

Volltext