Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis von van der Wel, Tom, Hilhorst, Riet, den Dulk, Hans, van den Hooven, Tim, Prins, Nienke M., Wijnakker, Joost A. P. M., Florea, Bogdan I., Lenselink, Eelke B., van Westen, Gerard J. P., Ruijtenbeek, Rob, Overkleeft, Herman S., Kaptein, Allard, Barf, Tjeerd, van der Stelt, Mario

Volltext

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474 von van Esbroeck, Annelot C. M., Janssen, Antonius P. A., Cognetta, Armand B., Ogasawara, Daisuke, Shpak, Guy, van der Kroeg, Mark, Kantae, Vasudev, Baggelaar, Marc P., de Vrij, Femke M. S., Deng, Hui, Allarà, Marco, Fezza, Filomena, Lin, Zhanmin, van der Wel, Tom, Soethoudt, Marjolein, Mock, Elliot D., den Dulk, Hans, Baak, Ilse L., Florea, Bogdan I., Hendriks, Giel, De Petrocellis, Luciano, Overkleeft, Herman S., Hankemeier, Thomas, De Zeeuw, Chris I., Di Marzo, Vincenzo, Maccarrone, Mauro, Cravatt, Benjamin F., Kushner, Steven A., van der Stelt, Mario

Volltext

Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition von Ogasawara, Daisuke, Deng, Hui, Viader, Andreu, Baggelaar, Marc P., Breman, Arjen, den Dulk, Hans, van den Nieuwendijk, Adrianus M. C. H., Soethoudt, Marjolein, van der Wel, Tom, Zhou, Juan, Overkleeft, Herman S., Sanchez-Alavez, Manuel, Mori, Simone, Nguyen, William, Conti, Bruno, Liu, Xiaojie, Chen, Yao, Liu, Qing-song, Cravatt, Benjamin F., van der Stelt, Mario

Volltext

Chemical Proteomics Reveals Off-Targets of the Anandamide Reuptake Inhibitor WOBE437 von Gagestein, Berend, Stevens, Anna F., Fazio, Domenico, Florea, Bogdan I., van der Wel, Tom, Bakker, Alexander T., Fezza, Filomena, Dulk, Hans den, Overkleeft, Herman S., Maccarrone, Mauro, van der Stelt, Mario

Volltext

Cytotoxic activity and cellular processing in human ovarian carcinoma cell lines of a new platinum(II) compound containing a fluorescent substituted propylene diamine ligand von Marqués-Gallego, Patricia, den Dulk, Hans, Brouwer, Jaap, Tanase, Stefania, Mutikainen, Ilpo, Turpeinen, Urho, Reedijk, Jan

Volltext

Folic Acid-Modified Mesoporous Silica Nanoparticles for Cellular and Nuclear Targeted Drug Delivery von Porta, Fabiola, Lamers, Gerda E. M., Morrhayim, Jess, Chatzopoulou, Antonia, Schaaf, Marcel, den Dulk, Hans, Backendorf, Claude, Zink, Jeffrey I., Kros, Alexander

Volltext

Development of an Activity-Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase-α in Brain von Baggelaar, Marc P., Janssen, Freek J., van Esbroeck, Annelot C. M., den Dulk, Hans, Allarà, Marco, Hoogendoorn, Sascha, McGuire, Ross, Florea, Bogdan I., Meeuwenoord, Nico, van den Elst, Hans, van der Marel, Gijsbert A., Brouwer, Jaap, Di Marzo, Vincenzo, Overkleeft, Herman S., van der Stelt, Mario

Volltext

The Square-Planar Cytotoxic [CuII(pyrimol)Cl] Complex Acts as an Efficient DNA Cleaver without Reductant von Maheswari, Palanisamy Uma, Roy, Sudeshna, den Dulk, Hans, Barends, Sharief, van Wezel, Gilles, Kozlevčar, Bojan, Gamez, Patrick, Reedijk, Jan

Volltext

Structure, Cytotoxicity, and DNA-Cleavage Properties of the Complex [CuII(pbt)Br2] von Maheswari, Palanisamy Uma, Ster, Martijn van der, Smulders, Simon, Barends, Sharief, Wezel, Gilles P. van, Massera, Chiara, Roy, Sudeshna, Dulk, Hans den, Gamez, Patrick, Reedijk, Jan

Volltext

A natural substrate-based fluorescence assay for inhibitor screening on diacylglycerol lipase α von van der Wel, Tom, Janssen, Freek J., Baggelaar, Marc P., Deng, Hui, den Dulk, Hans, Overkleeft, Herman S., van der Stelt, Mario

Volltext

Synthesis, characterization, in vitro antitumor activity, DNA-binding properties and electronic structure (DFT) of the new complex cis-(Cl,Cl)[RuIICl2(NO+)(terpy)]Cl von Karidi, Konstantina, Garoufis, Achilleas, Tsipis, Athanassios, Hadjiliadis, Nick, den Dulk, Hans, Reedijk, Jan

Volltext

Identification of α,β-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells von van Esbroeck, Annelot C M, Kantae, Vasudev, Di, Xinyu, van der Wel, Tom, den Dulk, Hans, Stevens, Anna F, Singh, Simar, Bakker, Alexander T, Florea, Bogdan I, Stella, Nephi, Overkleeft, Herman S, Hankemeier, Thomas, van der Stelt, Mario

Volltext

ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction von Baggelaar, Marc P, den Dulk, Hans, Florea, Bogdan I, Fazio, Domenico, Perruzza, Davide, Bernabò, Nicola, Raspa, Marcello, Janssen, Antonius P. A, Scavizzi, Ferdinando, Barboni, Barbara, Overkleeft, Hermen S, Maccarrone, Mauro, van der Stelt, Mario

Volltext

Random Mutagenesis of the Human Adenosine A2B Receptor Followed by Growth Selection in Yeast. Identification of Constitutively Active and Gain of Function Mutations von Beukers, Margot W., van Oppenraaij, Joris, van der Hoorn, Patrick P.W., Blad, Clara C., Dulk, Hans den, Brouwer, Jaap, IJzerman, Adriaan P.

Volltext

DNA cleavage and antitumour activity of platinum(II) and copper(II) compounds derived from 4-methyl-2-N-(2-pyridylmethyl)aminophenol: spectroscopic, electrochemical and biological... von Roy, Sudeshna, Maheswari, Palanisamy Uma, Lutz, Martin, Spek, Anthony L, den Dulk, Hans, Barends, Sharief, van Wezel, Gilles P, Hartl, Frantisek, Reedijk, Jan

Volltext

Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells von Koenders, Sebastiaan T. A, Wijaya, Lukas S, Erkelens, Martje N, Bakker, Alexander T, van der Noord, Vera E, van Rooden, Eva J, Burggraaff, Lindsey, Putter, Pasquale C, Botter, Else, Wals, Kim, van den Elst, Hans, den Dulk, Hans, Florea, Bogdan I, van de Water, Bob, van Westen, Gerard J. P, Mebius, Reina E, Overkleeft, Herman S, Le Dévédec, Sylvia E, van der Stelt, Mario

Volltext

Cellular accumulation and DNA platination of two new platinum(II) anticancer compounds based on anthracene derivatives as carrier ligands von Marqués-Gallego, Patricia, Kalayda, Ganna V., Jaehde, Ulrich, Dulk, Hans den, Brouwer, Jaap, Reedijk, Jan

Volltext

Relevance of the leaving group for antitumor activity of new platinum(II) compounds containing anthracene derivatives as a carrier ligand von Marqués-Gallego, Patricia, Contaldi, Simone, Dulk, Hans den, Monari, Magda, Brouwer, Jaap, Jaehde, Ulrich, Kalayda, Ganna V., Reedijk, Jan

Volltext

Accurate non-invasive image-based cytotoxicity assays for cultured cells von Marqués-Gallego, Patricia, den Dulk, Hans, Backendorf, Claude, Brouwer, Jaap, Reedijk, Jan, Burke, Julian F

Volltext

Anticancer Drug Resistance Induced by Disruption of the Saccharomyces cerevisiae NPR2 Gene: a Novel Component Involved in Cisplatin- and Doxorubicin-Provoked Cell Kill von Schenk, Paul W, Brok, Mariël, Boersma, Antonius W. M, Brandsma, Jourica A, Den Dulk, Hans, Burger, Herman, Stoter, Gerrit, Brouwer, Jaap, Nooter, Kees

Volltext