BRAF — a tumour-agnostic drug target with lineage-specific dependencies von Hanrahan, Aphrothiti J., Chen, Ziyu, Rosen, Neal, Solit, David B.

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Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies von Jordan, Emmet J, Kim, Hyunjae R, Arcila, Maria E, Barron, David, Chakravarty, Debyani, Gao, JianJiong, Chang, Matthew T, Ni, Andy, Kundra, Ritika, Jonsson, Philip, Jayakumaran, Gowtham, Gao, Sizhi Paul, Johnsen, Hannah C, Hanrahan, Aphrothiti J, Zehir, Ahmet, Rekhtman, Natasha, Ginsberg, Michelle S, Li, Bob T, Yu, Helena A, Paik, Paul K, Drilon, Alexander, Hellmann, Matthew D, Reales, Dalicia N, Benayed, Ryma, Rusch, Valerie W, Kris, Mark G, Chaft, Jamie E, Baselga, José, Taylor, Barry S, Schultz, Nikolaus, Rudin, Charles M, Hyman, David M, Berger, Michael F, Solit, David B, Ladanyi, Marc, Riely, Gregory J

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BRAF Mutations: The Discovery of Allele- and Lineage-Specific Differences von Hanrahan, Aphrothiti J, Solit, David B

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Prevalence and Co-Occurrence of Actionable Genomic Alterations in High-Grade Bladder Cancer von IYER, Gopa, AL-AHMADIE, Hikmat, ZABOR, Emily C, JANAKIRAMAN, Manickam, GARCIA-GROSSMAN, Ilana R, HEGUY, Adriana, VIALE, Agnes, BOCHNER, Bernard H, REUTER, Victor E, BAJORIN, Dean F, MILOWSKY, Matthew I, TAYLOR, Barry S, SCHULTZ, Nikolaus, SOLIT, David B, HANRAHAN, Aphrothiti J, OSTROVNAYA, Irina, BALAR, Arjun V, KIM, Philip H, LIN, Oscar, WEINHOLD, Nils, SANDER, Chris

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HER kinase inhibition in patients with HER2- and HER3-mutant cancers von Hyman, David M., Piha-Paul, Sarina A., Won, Helen, Rodon, Jordi, Saura, Cristina, Shapiro, Geoffrey I., Juric, Dejan, Quinn, David I., Moreno, Victor, Doger, Bernard, Mayer, Ingrid A., Boni, Valentina, Calvo, Emiliano, Loi, Sherene, Lockhart, Albert C., Erinjeri, Joseph P., Scaltriti, Maurizio, Ulaner, Gary A., Patel, Juber, Tang, Jiabin, Beer, Hannah, Selcuklu, S. Duygu, Hanrahan, Aphrothiti J., Bouvier, Nancy, Melcer, Myra, Murali, Rajmohan, Schram, Alison M., Smyth, Lillian M., Jhaveri, Komal, Li, Bob T., Drilon, Alexander, Harding, James J., Iyer, Gopa, Taylor, Barry S., Berger, Michael F., Cutler Jr, Richard E., Xu, Feng, Butturini, Anna, Eli, Lisa D., Mann, Grace, Farrell, Cynthia, Lalani, Alshad S., Bryce, Richard P., Arteaga, Carlos L., Meric-Bernstam, Funda, Baselga, José, Solit, David B.

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Genomic Characterization of Upper Tract Urothelial Carcinoma von Sfakianos, John P, Cha, Eugene K, Iyer, Gopa, Scott, Sasinya N, Zabor, Emily C, Shah, Ronak H, Ren, Qinghu, Bagrodia, Aditya, Kim, Philip H, Hakimi, A. Ari, Ostrovnaya, Irina, Ramirez, Ricardo, Hanrahan, Aphrothiti J, Desai, Neil B, Sun, Arony, Pinciroli, Patrizia, Rosenberg, Jonathan E, Dalbagni, Guido, Schultz, Nikolaus, Bajorin, Dean F, Reuter, Victor E, Berger, Michael F, Bochner, Bernard H, Al-Ahmadie, Hikmat A, Solit, David B, Coleman, Jonathan A

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Genome Sequencing Identifies a Basis for Everolimus Sensitivity von Iyer, Gopa, Hanrahan, Aphrothiti J., Milowsky, Matthew I., Al-Ahmadie, Hikmat, Scott, Sasinya N., Janakiraman, Manickam, Pirun, Mono, Sander, Chris, Socci, Nicholas D., Ostrovnaya, Irina, Viale, Agnes, Heguy, Adriana, Peng, Luke, Chan, Timothy A., Bochner, Bernard, Bajorin, Dean F., Berger, Michael F., Taylor, Barry S., Solit, David B.

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Loss of NF1 in Cutaneous Melanoma Is Associated with RAS Activation and MEK Dependence von NISSAN, Moriah H, PRATILAS, Christine A, MERGHOUB, Taha, RIBAS, Antoni, CHAPMAN, Paul B, YAEGER, Rona, TAYLOR, Barry S, SCHULTZ, Nikolaus, BERGER, Michael F, ROSEN, Neal, SOLIT, David B, JONES, Alexis M, RAMIREZ, Ricardo, WON, Helen, CAILIAN LIU, TIWARI, Shakuntala, LI KONG, HANRAHAN, Aphrothiti J, ZHAN YAO

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Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies von Solit, David B, Chan, Timothy A, Veeriah, Selvaraju, Taylor, Barry S, Meng, Shasha, Fang, Fang, Yilmaz, Emrullah, Vivanco, Igor, Janakiraman, Manickam, Schultz, Nikolaus, Hanrahan, Aphrothiti J, Pao, William, Ladanyi, Marc, Sander, Chris, Heguy, Adriana, Holland, Eric C, Paty, Philip B, Mischel, Paul S, Liau, Linda, Cloughesy, Timothy F, Mellinghoff, Ingo K

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Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer von Bielski, Craig M., Donoghue, Mark T.A., Gadiya, Mayur, Hanrahan, Aphrothiti J., Won, Helen H., Chang, Matthew T., Jonsson, Philip, Penson, Alexander V., Gorelick, Alexander, Harris, Christopher, Schram, Alison M., Syed, Aijazuddin, Zehir, Ahmet, Chapman, Paul B., Hyman, David M., Solit, David B., Shannon, Kevin, Chandarlapaty, Sarat, Berger, Michael F., Taylor, Barry S.

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Genetic predictors of MEK dependence in non-small cell lung cancer von Pratilas, Christine A, Hanrahan, Aphrothiti J, Halilovic, Ensar, Persaud, Yogindra, Soh, Junichi, Chitale, Dhananjay, Shigematsu, Hisayuki, Yamamoto, Hiromasa, Sawai, Ayana, Janakiraman, Manickam, Taylor, Barry S, Pao, William, Toyooka, Shinichi, Ladanyi, Marc, Gazdar, Adi, Rosen, Neal, Solit, David B

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Leveraging Systematic Functional Analysis to Benchmark an In Silico Framework Distinguishes Driver from Passenger MEK Mutants in Cancer von Hanrahan, Aphrothiti J., Sylvester, Brooke E., Chang, Matthew T., Elzein, Arijh, Gao, Jianjiong, Han, Weiwei, Liu, Ye, Xu, Dong, Gao, Sizhi P., Gorelick, Alexander N., Jones, Alexis M., Kiliti, Amber J., Nissan, Moriah H., Nimura, Clare A., Poteshman, Abigail N., Yao, Zhan, Gao, Yijun, Hu, Wenhuo, Wise, Hannah C., Gavrila, Elena, Shoushtari, Alexander N., Tiwari, Shakuntala, Viale, Agnes, Abdel-Wahab, Omar, Merghoub, Taha, Berger, Michael F., Rosen, Neal, Taylor, Barry S., Solit, David B.

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AKT1 E17K Inhibits Cancer Cell Migration by Abrogating beta-Catenin Signaling von Gao, Sizhi Paul, Kiliti, Amber J., Zhang, Kai, Vasani, Naresh, Mao, Ninghui, Jordan, Emmet, Wise, Hannah C., Bhattarai, Tripti Shrestha, Hu, Wenhuo, Dorso, Madeline, Rodrigues, James A., Kim, Kwanghee, Hanrahan, Aphrothiti J., Razavi, Pedram, Carver, Brett, Chandarlapaty, Sarat, Reis-Filho, Jorge S., Taylor, Barry S., Solit, David B.

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Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy von Al-Ahmadie, Hikmat, Iyer, Gopa, Hohl, Marcel, Asthana, Saurabh, Inagaki, Akiko, Schultz, Nikolaus, Hanrahan, Aphrothiti J, Scott, Sasinya N, Brannon, A Rose, McDermott, Gregory C, Pirun, Mono, Ostrovnaya, Irina, Kim, Philip, Socci, Nicholas D, Viale, Agnes, Schwartz, Gary K, Reuter, Victor, Bochner, Bernard H, Rosenberg, Jonathan E, Bajorin, Dean F, Berger, Michael F, Petrini, John H J, Solit, David B, Taylor, Barry S

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Genomic complexity and AKT dependence in serous ovarian cancer von Hanrahan, Aphrothiti J, Schultz, Nikolaus, Westfal, Maggie L, Sakr, Rita A, Giri, Dilip D, Scarperi, Stefano, Janakiraman, Manickam, Janikariman, Manickam, Olvera, Narciso, Stevens, Ellen V, She, Qing-Bai, Aghajanian, Carol, King, Tari A, Stanchina, Elisa de, Spriggs, David R, Heguy, Adriana, Taylor, Barry S, Sander, Chris, Rosen, Neal, Levine, Douglas A, Solit, David B

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RAF/MEK dependence of KRAS-mutant pancreatic ductal adenocarcinomas von Hanrahan, Aphrothiti J, Solit, David B

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Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts von Kim, Kwanghee, Hu, Wenhuo, Audenet, François, Almassi, Nima, Hanrahan, Aphrothiti J., Murray, Katie, Bagrodia, Aditya, Wong, Nathan, Clinton, Timothy N., Dason, Shawn, Mohan, Vishnu, Jebiwott, Sylvia, Nagar, Karan, Gao, Jianjiong, Penson, Alex, Hughes, Chris, Gordon, Benjamin, Chen, Ziyu, Dong, Yiyu, Watson, Philip A., Alvim, Ricardo, Elzein, Arijh, Gao, Sizhi P., Cocco, Emiliano, Santin, Alessandro D., Ostrovnaya, Irina, Hsieh, James J., Sagi, Irit, Pietzak, Eugene J., Hakimi, A. Ari, Rosenberg, Jonathan E., Iyer, Gopa, Vargas, Herbert A., Scaltriti, Maurizio, Al-Ahmadie, Hikmat, Solit, David B., Coleman, Jonathan A.

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Author Correction: HER kinase inhibition in patients with HER2- and HER3-mutant cancers von Hyman, David M., Piha-Paul, Sarina A., Won, Helen, Rodon, Jordi, Saura, Cristina, Shapiro, Geoffrey I., Juric, Dejan, Quinn, David I., Moreno, Victor, Doger, Bernard, Mayer, Ingrid A., Boni, Valentina, Calvo, Emiliano, Loi, Sherene, Lockhart, Albert C., Erinjeri, Joseph P., Scaltriti, Maurizio, Ulaner, Gary A., Patel, Juber, Tang, Jiabin, Beer, Hannah, Selcuklu, S. Duygu, Hanrahan, Aphrothiti J., Bouvier, Nancy, Melcer, Myra, Murali, Rajmohan, Schram, Alison M., Smyth, Lillian M., Jhaveri, Komal, Li, Bob T., Drilon, Alexander, Harding, James J., Iyer, Gopa, Taylor, Barry S., Berger, Michael F., Cutler, Richard E., Xu, Feng, Butturini, Anna, Eli, Lisa D., Mann, Grace, Farrell, Cynthia, Lalani, Alshad S., Bryce, Richard P., Arteaga, Carlos L., Meric-Bernstam, Funda, Baselga, José, Solit, David B.

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Lung cancer profiling: genetic and molecular predictors of MEK-dependence von Hanrahan, Aphrothiti J., Solit, David B.

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Abstract 36: Functional characterization of ERBB2 mutations and response to targeted therapies von Johnsen, Hannah, Hanrahan, Aphrothiti, Jones, Alexis, Solit, David

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