Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age von Ferreira, Rita, Schneekloth, Jr, John S, Panov, Konstantin I, Hannan, Katherine M, Hannan, Ross D

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A functional genetic screen defines the AKT-induced senescence signaling network von Chan, Keefe T., Blake, Shaun, Zhu, Haoran, Kang, Jian, Trigos, Anna S., Madhamshettiwar, Piyush B., Diesch, Jeannine, Paavolainen, Lassi, Horvath, Peter, Hannan, Ross D., George, Amee J., Sanij, Elaine, Hannan, Katherine M., Simpson, Kaylene J., Pearson, Richard B.

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Regulation of rDNA transcription in response to growth factors, nutrients and energy von Kusnadi, Eric P., Hannan, Katherine M., Hicks, Rodney J., Hannan, Ross D., Pearson, Richard B., Kang, Jian

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New Roles for the Nucleolus in Health and Disease von Núñez Villacís, Lorena, Wong, Mei S., Ferguson, Laura L., Hein, Nadine, George, Amee J., Hannan, Katherine M.

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Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma von Devlin, Jennifer R, Hannan, Katherine M, Hein, Nadine, Cullinane, Carleen, Kusnadi, Eric, Ng, Pui Yee, George, Amee J, Shortt, Jake, Bywater, Megan J, Poortinga, Gretchen, Sanij, Elaine, Kang, Jian, Drygin, Denis, O'Brien, Sean, Johnstone, Ricky W, McArthur, Grant A, Hannan, Ross D, Pearson, Richard B

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Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors von Sheppard, Karen E, Cullinane, Carleen, Hannan, Katherine M, Wall, Meaghan, Chan, Joanna, Barber, Frances, Foo, Jung, Cameron, Donald, Neilsen, Amelia, Ng, Pui, Ellul, Jason, Kleinschmidt, Margarete, Kinross, Kathryn M, Bowtell, David D, Christensen, James G, Hicks, Rodney J, Johnstone, Ricky W, McArthur, Grant A, Hannan, Ross D, Phillips, Wayne A, Pearson, Richard B

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Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling von Quin, Jaclyn, Chan, Keefe T, Devlin, Jennifer R, Cameron, Donald P, Diesch, Jeannine, Cullinane, Carleen, Ahern, Jessica, Khot, Amit, Hein, Nadine, George, Amee J, Hannan, Katherine M, Poortinga, Gretchen, Sheppard, Karen E, Khanna, Kum Kum, Johnstone, Ricky W, Drygin, Denis, McArthur, Grant A, Pearson, Richard B, Sanij, Elaine, Hannan, Ross D

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Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis von Kerry, Louise E, Pegg, Elaine E, Cameron, Donald P, Budzak, James, Poortinga, Gretchen, Hannan, Katherine M, Hannan, Ross D, Rudenko, Gloria

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mTOR-Dependent Regulation of Ribosomal Gene Transcription Requires S6K1 and Is Mediated by Phosphorylation of the Carboxy-Terminal Activation Domain of the Nucleolar Transcription... von Hannan, Katherine M., Brandenburger, Yves, Jenkins, Anna, Sharkey, Kerith, Cavanaugh, Alice, Rothblum, Lawrence, Moss, Tom, Poortinga, Gretchen, McArthur, Grant A., Pearson, Richard B., Hannan, Ross D.

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UBF levels determine the number of active ribosomal RNA genes in mammals von Sanij, Elaine, Poortinga, Gretchen, Sharkey, Kerith, Hung, Sandy, Holloway, Timothy P, Quin, Jaclyn, Robb, Elysia, Wong, Lee H, Thomas, Walter G, Stefanovsky, Victor, Moss, Tom, Rothblum, Lawrence, Hannan, Katherine M, McArthur, Grant A, Pearson, Richard B, Hannan, Ross D

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The nucleolus: an emerging target for cancer therapy von Hein, Nadine, Hannan, Katherine M, George, Amee J, Sanij, Elaine, Hannan, Ross D

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Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function von Jastrzebski, Katarzyna, Hannan, Katherine M., Tchoubrieva, Elissaveta B., Hannan, Ross D., Pearson, Richard B.

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MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation von Poortinga, Gretchen, Hannan, Katherine M, Snelling, Hayley, Walkley, Carl R, Jenkins, Anna, Sharkey, Kerith, Wall, Meaghan, Brandenburger, Yves, Palatsides, Manuela, Pearson, Richard B, McArthur, Grant A, Hannan, Ross D

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High-Content Imaging Approaches to Quantitate Stress-Induced Changes in Nucleolar Morphology von He, Jin-Shu, Soo, Priscilla, Evers, Maurits, Parsons, Kate M, Hein, Nadine, Hannan, Katherine M, Hannan, Ross D, George, Amee J

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Targeting RNA Polymerase I Transcription Activity in Osteosarcoma: Pre-Clinical Molecular and Animal Treatment Studies von Kang, Chang-Won, Blackburn, Anneke C, Loh, Amos Hong Pheng, Hong, Kuick Chick, Goh, Jian Yuan, Hein, Nadine, Drygin, Denis, Parish, Chris R, Hannan, Ross D, Hannan, Katherine M, Coupland, Lucy A

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rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461 von Son, Jinbae, Hannan, Katherine M, Poortinga, Gretchen, Hein, Nadine, Cameron, Donald P, Ganley, Austen R D, Sheppard, Karen E, Pearson, Richard B, Hannan, Ross D, Sanij, Elaine

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The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy von Woods, Simone J., Hannan, Katherine M., Pearson, Richard B., Hannan, Ross D.

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A specific role for AKT3 in the genesis of ovarian cancer through modulation of G2-M phase transition von CRISTIANO, Briony E, CHAN, Joanna C, HANNAN, Katherine M, LUNDIE, Nicole A, MARMY-CONUS, Nelly J, CAMPBELL, Ian G, PHILLIPS, Wayne A, ROBBIE, Melissa, HANNAN, Ross D, PEARSON, Richard B

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CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer von Sanij, Elaine, Hannan, Katherine M., Xuan, Jiachen, Yan, Shunfei, Ahern, Jessica E., Trigos, Anna S., Brajanovski, Natalie, Son, Jinbae, Chan, Keefe T., Kondrashova, Olga, Lieschke, Elizabeth, Wakefield, Matthew J., Frank, Daniel, Ellis, Sarah, Cullinane, Carleen, Kang, Jian, Poortinga, Gretchen, Nag, Purba, Deans, Andrew J., Khanna, Kum Kum, Mileshkin, Linda, McArthur, Grant A., Soong, John, Berns, Els M. J. J., Hannan, Ross D., Scott, Clare L., Sheppard, Karen E., Pearson, Richard B.

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Too much or too little: Harnessing senescence to control oncogene-driven cancer von Hannan, Katherine M., Pearson, Richard B.

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