Assembly assay identifies a critical region of human fibrillin-1 required for 10-12 nm diameter microfibril biogenesis von Jensen, Sacha A., Atwa, Ondine, Handford, Penny A.

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Notch receptor–ligand binding and activation: Insights from molecular studies von Chillakuri, Chandramouli R., Sheppard, Devon, Lea, Susan M., Handford, Penny A.

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Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands von Taylor, Paul, Takeuchi, Hideyuki, Sheppard, Devon, Chillakuri, Chandramouli, Lea, Susan M., Haltiwanger, Robert S., Handford, Penny A.

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Dissecting the Fibrillin Microfibril: Structural Insights into Organization and Function von Jensen, Sacha A., Robertson, Ian B., Handford, Penny A.

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Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands von Suckling, Richard J, Korona, Boguslawa, Whiteman, Pat, Chillakuri, Chandramouli, Holt, Laurie, Handford, Penny A, Lea, Susan M

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Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern von Pfeffer, Inga, Brewitz, Lennart, Krojer, Tobias, Jensen, Sacha A., Kochan, Grazyna T., Kershaw, Nadia J., Hewitson, Kirsty S., McNeill, Luke A., Kramer, Holger, Münzel, Martin, Hopkinson, Richard J., Oppermann, Udo, Handford, Penny A., McDonough, Michael A., Schofield, Christopher J.

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Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies von Weisshuhn, Philip C., Sheppard, Devon, Taylor, Paul, Whiteman, Pat, Lea, Susan M., Handford, Penny A., Redfield, Christina

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C-terminal propeptide is required for fibrillin-1 secretion and blocks premature assembly through linkage to domains cbEGF41-43 von Jensen, Sacha A., Aspinall, Georgia, Handford, Penny A.

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A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans -activation and cis -inhibition von Jensen, Sacha, Baron, Martin, Jin, Boquan, Johnson, Steven, Redfield, Christina, Lea, Susan M, Whiteman, Pat, Cordle, Jemima, de Madrid, Beatriz Hernández, Roversi, Pietro, Shimizu, Hideyuki, Handford, Penny A, Zi Yan Tay, Joyce, Wilkin, Marian B

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NMR spectroscopic and bioinformatic analyses of the LTBP1 C-terminus reveal a highly dynamic domain organisation von Robertson, Ian B, Handford, Penny A, Redfield, Christina

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Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands von Chillakuri, Chandramouli R., Sheppard, Devon, Ilagan, Ma. Xenia G., Holt, Laurie R., Abbott, Felicity, Liang, Shaoyan, Kopan, Raphael, Handford, Penny A., Lea, Susan M.

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Structure of the Fibrillin-1 N-Terminal Domains Suggests that Heparan Sulfate Regulates the Early Stages of Microfibril Assembly von Yadin, David A., Robertson, Ian B., McNaught-Davis, Joanne, Evans, Paul, Stoddart, David, Handford, Penny A., Jensen, Sacha A., Redfield, Christina

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Somatic mutant clones colonize the human esophagus with age von Martincorena, Iñigo, Fowler, Joanna C, Wabik, Agnieszka, Lawson, Andrew R J, Abascal, Federico, Hall, Michael W J, Cagan, Alex, Murai, Kasumi, Mahbubani, Krishnaa, Stratton, Michael R, Fitzgerald, Rebecca C, Handford, Penny A, Campbell, Peter J, Saeb-Parsy, Kourosh, Jones, Philip H

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Localization of the Delta-like-1-binding Site in Human Notch-1 and Its Modulation by Calcium Affinity von Cordle, Jemima, RedfieldZ, Christina, Stacey, Martin, van der Merwe, P. Anton, Willis, Antony C., Champion, Brian R., Hambleton, Sophie, Handford, Penny A.

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Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling von Takeuchi, Hideyuki, Schneider, Michael, Williamson, Daniel B., Ito, Atsuko, Takeuchi, Megumi, Handford, Penny A., Haltiwanger, Robert S.

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Structure and Interdomain Interactions of a Hybrid Domain: A Disulphide-Rich Module of the Fibrillin/LTBP Superfamily of Matrix Proteins von Jensen, Sacha A., Iqbal, Sarah, Lowe, Edward D., Redfield, Christina, Handford, Penny A.

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Molecular Basis for Jagged-1/Serrate Ligand Recognition by the Notch Receptor von Whiteman, Pat, de Madrid, Beatriz Hernandez, Taylor, Paul, Li, Demin, Heslop, Rebecca, Viticheep, Nattnee, Tan, Joyce Zi, Shimizu, Hideyuki, Callaghan, Juliana, Masiero, Massimo, Li, Ji Liang, Banham, Alison H., Harris, Adrian L., Lea, Susan M., Redfield, Christina, Baron, Martin, Handford, Penny A.

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ELTD1 is present in extracellular vesicles derived from endothelial cells as a cleaved extracellular domain which induces in vivo angiogenesis von Sheldon, Helen, Zhang, Wei, Bridges, Esther, Ang, Koon Hwee, Lin, Salwa, Masiero, Massimo, Li, Demin, Handford, Penny A., Whiteman, Pat, Fischer, Roman, Buffa, Francesca, Vatish, Manu, Banham, Alison H., Harris, Adrian L.

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New insights into the structure, assembly and biological roles of 10-12 nm connective tissue microfibrils from fibrillin-1 studies von Jensen, Sacha A, Handford, Penny A

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CRB1 mutation spectrum in inherited retinal dystrophies von den Hollander, Anneke I., Davis, Jason, van der Velde-Visser, Saskia D., Zonneveld, Marijke N., Pierrottet, Chiara O., Koenekoop, Robert K., Kellner, Ulrich, van den Born, L. Ingeborgh, Heckenlively, John R., Hoyng, Carel B., Handford, Penny A., Roepman, Ronald, Cremers, Frans P.M.

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