A multicentre, randomised, double-blind, placebo-controlled, crossover study to investigate the efficacy, safety, tolerability and pharmacokinetics of repeat doses of inhaled nemir... von Khindri, Sanjeev, Cahn, Anthony, Begg, Malcolm, Montembault, Mickael, Leemereise, Claudia, Cui, Yi, Hogg, Annabel, Wajdner, Hannah, Yang, Shuying, Roberston, Jon, Hamblin, J Nicole, Ludwig-Sengpiel, Andrea, Kornmann, Oliver, Hessel, Edith

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PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner von Stark, Anne-Katrien, Chandra, Anita, Chakraborty, Krishnendu, Alam, Rafeah, Carbonaro, Valentina, Clark, Jonathan, Sriskantharajah, Srividya, Bradley, Glyn, Richter, Alex G., Banham-Hall, Edward, Clatworthy, Menna R., Nejentsev, Sergey, Hamblin, J. Nicole, Hessel, Edith M., Condliffe, Alison M., Okkenhaug, Klaus

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Pyrazolopyridines as potent PDE4B inhibitors: 5-Heterocycle SAR von Mitchell, Charlotte J., Ballantine, Stuart P., Coe, Diane M., Cook, Caroline M., Delves, Christopher J., Dowle, Mike D., Edlin, Chris D., Hamblin, J. Nicole, Holman, Stuart, Johnson, Martin R., Jones, Paul S., Keeling, Sue E., Kranz, Michael, Lindvall, Mika, Lucas, Fiona S., Neu, Margarete, Solanke, Yemisi E., Somers, Don O., Trivedi, Naimisha A., Wiseman, Joanne O.

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Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3‑Kinase δ for the Treatment of Respiratory Disease von Down, Kenneth, Amour, Augustin, Baldwin, Ian R, Cooper, Anthony W. J, Deakin, Angela M, Felton, Leigh M, Guntrip, Stephen B, Hardy, Charlotte, Harrison, Zoë A, Jones, Katherine L, Jones, Paul, Keeling, Suzanne E, Le, Joelle, Livia, Stefano, Lucas, Fiona, Lunniss, Christopher J, Parr, Nigel J, Robinson, Ed, Rowland, Paul, Smith, Sarah, Thomas, Daniel A, Vitulli, Giovanni, Washio, Yoshiaki, Hamblin, J. Nicole

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Safety, Tolerability, and Pharmacokinetics of Single and Repeat Doses of Nemiralisib Administered via the Ellipta Dry Powder Inhaler to Healthy Subjects von Wilson, Robert, Jarvis, Emily, Montembault, Mickael, Hamblin, J. Nicole, Hessel, Edith M., Cahn, Anthony

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Factor Xa Inhibitors:  S1 Binding Interactions of a Series of N-{(3S)-1-[(1S)-1-Methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides von Chan, Chuen, Borthwick, Alan D, Brown, David, Burns-Kurtis, Cynthia L, Campbell, Matthew, Chaudry, Laiq, Chung, Chun-wa, Convery, Máire A, Hamblin, J. Nicole, Johnstone, Lisa, Kelly, Henry A, Kleanthous, Savvas, Patikis, Angela, Patel, Champa, Pateman, Anthony J, Senger, Stefan, Shah, Gita P, Toomey, John R, Watson, Nigel S, Weston, Helen E, Whitworth, Caroline, Young, Robert J, Zhou, Ping

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Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase δ Inhibitor von Begg, Malcolm, Edwards, Chris D, Hamblin, J Nicole, Pefani, Eleni, Wilson, Robert, Gilbert, Jane, Vitulli, Giovanni, Mallett, David, Morrell, Josie, Hingle, Martin I, Uddin, Sorif, Ehtesham, Filzah, Marotti, Miriam, Harrell, Andrew, Newman, Carla F, Fernando, Disala, Clark, Jonathan, Cahn, Anthony, Hessel, Edith M

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Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma von Smil, David, Wong, Jong Fu, Williams, Eleanor P, Adamson, Roslin J, Howarth, Alison, McLeod, David A, Mamai, Ahmed, Kim, Soyoung, Wilson, Brian J, Kiyota, Taira, Aman, Ahmed, Owen, Julie, Poda, Gennady, Horiuchi, Kurumi Y, Kuznetsova, Ekaterina, Ma, Haiching, Hamblin, J. Nicole, Cramp, Sue, Roberts, Owen G, Edwards, Aled M, Uehling, David, Al-awar, Rima, Bullock, Alex N, O’Meara, Jeff A, Isaac, Methvin B

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Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target von Henley, Zoë A, Amour, Augustin, Barton, Nick, Bantscheff, Marcus, Bergamini, Giovanna, Bertrand, Sophie M, Convery, Máire, Down, Kenneth, Dümpelfeld, Birgit, Edwards, Chris D, Grandi, Paola, Gore, Paul M, Keeling, Steve, Livia, Stefano, Mallett, David, Maxwell, Aoife, Price, Mark, Rau, Christina, Reinhard, Friedrich B. M, Rowedder, James, Rowland, Paul, Taylor, Jonathan A, Thomas, Daniel A, Hessel, Edith M, Hamblin, J. Nicole

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Developing inhaled drugs for respiratory diseases: A medicinal chemistry perspective von Pasqua, Elisa, Hamblin, Nicole, Edwards, Christine, Baker-Glenn, Charles, Hurley, Chris

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Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode von Down, Kenneth, Amour, Augustin, Anderson, Niall A, Barton, Nick, Campos, Sebastien, Cannons, Edward P, Clissold, Cole, Convery, Maire A, Coward, John J, Doyle, Kevin, Duempelfeld, Birgit, Edwards, Christopher D, Goldsmith, Michael D, Krause, Jana, Mallett, David N, McGonagle, Grant A, Patel, Vipulkumar K, Rowedder, James, Rowland, Paul, Sharpe, Andrew, Sriskantharajah, Srividya, Thomas, Daniel A, Thomson, Douglas W, Uddin, Sorif, Hamblin, J. Nicole, Hessel, Edith M

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Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3‑Kinase δ through a Deconstruction and Regrowth Approach von Barton, Nick, Convery, Máire, Cooper, Anthony W. J, Down, Kenneth, Hamblin, J. Nicole, Inglis, Graham, Peace, Simon, Rowedder, James, Rowland, Paul, Taylor, Jonathan A, Wellaway, Natalie

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An Inhaled PI3K delta Inhibitor Improves Recovery in Acutely Exacerbating COPD Patients: A Randomized Trial von Cahn, Anthony, Hamblin, J. Nicole, Robertson, Jon, Begg, Malcolm, Jarvis, Emily, Wilson, Robert, Dear, Gordon, Leemereise, Claudia, Cui, Yi, Mizuma, Maki, Montembault, Mickael, Van Holsbeke, Cedric, Vos, Wim, De Backer, Wilfried, De Backer, Jan, Hessel, Edith M.

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Exploring PI3K delta Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials von Begg, Malcolm, Hamblin, J. Nicole, Jarvis, Emily, Bradley, Glyn, Mark, Stephen, Michalovich, David, Lennon, Mark, Wajdner, Hannah E., Amour, Augustin, Wilson, Robert, Saunders, Ken, Tanaka, Rikako, Arai, Saki, Tang, Teresa, Van Holsbeke, Cedric, De Backer, Jan, Vos, Wim, Titlestad, Ingrid L., FitzGerald, J. Mark, Killian, Kieran, Bourbeau, Jean, Poirier, Claude, Maltais, Francois, Cahn, Anthony, Hessel, Edith M.

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Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors von Watson, Nigel S., Brown, David, Campbell, Matthew, Chan, Chuen, Chaudry, Laiq, Convery, Máire A., Fenwick, Rebecca, Hamblin, J. Nicole, Haslam, Claudine, Kelly, Henry A., King, N. Paul, Kurtis, Cynthia L., Leach, Andrew R., Manchee, Gary R., Mason, Andrew M., Mitchell, Charlotte, Patel, Champa, Patel, Vipulkumar K., Senger, Stefan, Shah, Gita P., Weston, Helen E., Whitworth, Caroline, Young, Robert J.

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Abstract 4457: Open science medicinal chemistry: Towards a treatment for DIPG von Cramp, Sue, Hamblin, Nicole, O'Meara, Jeff, Edwards, Aled, Roberts, Owen, Bullock, Alex, Brennan, Paul

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Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors von Hamblin, J. Nicole, Angell, Tony D.R., Ballantine, Stuart P., Cook, Caroline M., Cooper, Anthony W.J., Dawson, John, Delves, Christopher J., Jones, Paul S., Lindvall, Mika, Lucas, Fiona S., Mitchell, Charlotte J., Neu, Margarete Y., Ranshaw, Lisa E., Solanke, Yemisi E., Somers, Don O., Wiseman, Joanne O.

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Targeting phosphoinositide 3-kinase δ for the treatment of respiratory diseases von Sriskantharajah, Srividya, Hamblin, Nicole, Worsley, Sally, Calver, Andrew R., Hessel, Edith M., Amour, Augustin

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Dimeric Zanamivir Conjugates with Various Linking Groups Are Potent, Long-Lasting Inhibitors of Influenza Neuraminidase Including H5N1 Avian Influenza von Macdonald, Simon J. F, Cameron, Rachel, Demaine, Derek A, Fenton, Rob J, Foster, Graham, Gower, David, Hamblin, J. Nicole, Hamilton, Stephanie, Hart, Graham J, Hill, Alan P, Inglis, Graham G. A, Jin, Betty, Jones, Haydn T, McConnell, Darryl B, McKimm-Breschkin, Jennifer, Mills, Gail, Nguyen, Van, Owens, Ian J, Parry, Nigel, Shanahan, Stephen E, Smith, Donna, Watson, Keith G, Wu, Wen-Yang, Tucker, Simon P

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Potent and Long-Acting Dimeric Inhibitors of Influenza Virus Neuraminidase Are Effective at a Once-Weekly Dosing Regimen von MACDONALD, Simon J. F, WATSON, Keith G, INGLIS, Graham G. A, JIN, Betty, JONES, Haydn T, MCCONNELL, Darryl B, MASON, Andy M, NGUYEN, Van, OWENS, Ian J, PARRY, Nigel, REECE, Phillip A, SHANAHAN, Stephen E, CAMERON, Rachel, SMITH, Donna, WU, Wen-Yang, TUCKER, Simon P, CHALMERS, David K, DEMAINE, Derek A, FENTON, Rob J, GOWER, David, HAMBLIN, J. Nicole, HAMILTON, Stephanie, HART, Graham J

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