The integration of pharmacophore-based 3D QSAR modeling and virtual screening in safety profiling: A case study to identify antagonistic activities against adenosine receptor, A2A,... von Fan, Fan, Toledo Warshaviak, Dora, Hamadeh, Hisham K, Dunn, 2nd, Robert T

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A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development von Morgan, Ryan E, van Staden, Carlo J, Chen, Yuan, Kalyanaraman, Natarajan, Kalanzi, Jackson, Dunn, 2nd, Robert T, Afshari, Cynthia A, Hamadeh, Hisham K

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Perturbation of microRNAs in rat heart during chronic doxorubicin treatment von Vacchi-Suzzi, Caterina, Bauer, Yasmina, Berridge, Brian R, Bongiovanni, Sandrine, Gerrish, Kevin, Hamadeh, Hisham K, Letzkus, Martin, Lyon, Jonathan, Moggs, Jonathan, Paules, Richard S, Pognan, François, Staedtler, Frank, Vidgeon-Hart, Martin P, Grenet, Olivier, Couttet, Philippe

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Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development von Morgan, Ryan E., Trauner, Michael, van Staden, Carlo J., Lee, Paul H., Ramachandran, Bharath, Eschenberg, Michael, Afshari, Cynthia A., Qualls, Charles W., Lightfoot-Dunn, Ruth, Hamadeh, Hisham K.

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A forward selection algorithm to identify mutually exclusive alterations in cancer studies von Zhang, Zeyu, Yang, Yaning, Zhou, Yinsheng, Fang, Hongyan, Yuan, Min, Sasser, Kate, Hamadeh, Hisham, Xu, Xu Steven

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Modeling Therapeutic Antibody-Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform von Long, Thomas J, Cosgrove, Patrick A, Dunn, 2nd, Robert T, Stolz, Donna B, Hamadeh, Hisham, Afshari, Cynthia, McBride, Helen, Griffith, Linda G

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The evolution of bioinformatics in toxicology: advancing toxicogenomics von Afshari, Cynthia A, Hamadeh, Hisham K, Bushel, Pierre R

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Challenges to Using Big Data in Cancer von Sweeney, Shawn M, Hamadeh, Hisham K, Abrams, Natalie, Adam, Stacey J, Brenner, Sara, Connors, Dana E, Davis, Gerard J, Fiore, Louis, Gawel, Susan H, Grossman, Robert L, Hanlon, Sean E, Hsu, Karl, Kelloff, Gary J, Kirsch, Ilan R, Louv, Bill, McGraw, Deven, Meng, Frank, Milgram, Daniel, Miller, Robert S, Morgan, Emily, Mukundan, Lata, O'Brien, Thomas, Robbins, Paul, Rubin, Eric H, Rubinstein, Wendy S, Salmi, Liz, Schaller, Teilo, Shi, George, Sigman, Caroline C, Srivastava, Sudhir

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Efficient algorithms for covariate analysis with dynamic data using nonlinear mixed-effects model von Yuan, Min, Zhu, Zhi, Yang, Yaning, Zhao, Minghua, Sasser, Kate, Hamadeh, Hisham, Pinheiro, Jose, Xu, Xu Steven

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Genome-scale metabolic model of the rat liver predicts effects of diet restriction von Baloni, Priyanka, Sangar, Vineet, Yurkovich, James T., Robinson, Max, Taylor, Scott, Karbowski, Christine M., Hamadeh, Hisham K., He, Yudong D., Price, Nathan D.

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Case Studies for Overcoming Challenges in Using Big Data in Cancer von Sweeney, Shawn M, Hamadeh, Hisham K, Abrams, Natalie, Adam, Stacey J, Brenner, Sara, Connors, Dana E, Davis, Gerard J, Fiore, Louis D, Gawel, Susan H, Grossman, Robert L, Hanlon, Sean E, Hsu, Karl, Kelloff, Gary J, Kirsch, Ilan R, Louv, Bill, McGraw, Deven, Meng, Frank, Milgram, Daniel, Miller, Robert S, Morgan, Emily, Mukundan, Lata, O'Brien, Thomas, Robbins, Paul, Rubin, Eric H, Rubinstein, Wendy S, Salmi, Liz, Schaller, Teilo H, Shi, George, Sigman, Caroline C, Srivastava, Sudhir

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Diverse Roles of the Nuclear Orphan Receptor CAR in Regulating Hepatic Genes in Response to Phenobarbital von Ueda, Akiko, Hamadeh, Hisham K., Webb, Heather K., Yamamoto, Yukio, Sueyoshi, Tatsuya, Afshari, Cynthia A., Lehmann, Jürgen M., Negishi, Masahiko

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Common handling procedures conducted in preclinical safety studies result in minimal hepatic gene expression changes in Sprague-Dawley rats von He, Yudong D, Karbowski, Christine M, Werner, Jon, Everds, Nancy, Di Palma, Chris, Chen, Yuan, Higgins-Garn, Marnie, Tran, Sandra, Afshari, Cynthia A, Hamadeh, Hisham K

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Identification of Putative Gene-Based Markers of Renal Toxicity von Amin, Rupesh P., Vickers, Alison E., Sistare, Frank, Thompson, Karol L., Roman, Richard J., Lawton, Michael, Kramer, Jeffrey, Hamadeh, Hisham K., Collins, Jennifer, Grissom, Sherry, Bennett, Lee, Tucker, C. Jeffrey, Wild, Stacie, Kind, Clive, Oreffo, Victor, Davis, John W., Curtiss, Sandra, Naciff, Jorge M., Cunningham, Michael, Tennant, Raymond, Stevens, James, Car, Bruce, Bertram, Timothy A., Afshari, Cynthia A.

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Gene Expression Analysis Reveals Chemical-Specific Profiles von Hamadeh, Hisham K., Bushel, Pierre R., Jayadev, Supriya, Martin, Karla, DiSorbo, Olimpia, Sieber, Stella, Bennett, Lee, Tennant, Raymond, Stoll, Raymond, Barrett, J. Carl, Blanchard, Kerry, Paules, Richard S., Afshari, Cynthia A.

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Improving accuracy of GPT-3/4 results on biomedical data using a retrieval-augmented language model von Soong, David, Sridhar, Sriram, Si, Han, Wagner, Jan-Samuel, Sá, Ana Caroline Costa, Yu, Christina Y, Karagoz, Kubra, Guan, Meijian, Kumar, Sanyam, Hamadeh, Hisham, Higgs, Brandon W

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Oxidative stress and its role in skin disease von Trouba, Kevin J, Hamadeh, Hisham K, Amin, Rupesh P, Germolec, Dori R

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Prediction of Compound Signature Using High Density Gene Expression Profiling von Hamadeh, Hisham K., Bushel, Pierre R., Jayadev, Supriya, DiSorbo, Olimpia, Bennett, Lee, Li, Leping, Tennant, Raymond, Stoll, Raymond, Barrett, J. Carl, Paules, Richard S., Blanchard, Kerry, Afshari, Cynthia A.

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A systematic assessment of mitochondrial function identified novel signatures for drug-induced mitochondrial disruption in cells von Li, Nianyu, Oquendo, Elisa, Capaldi, Roderick A, Robinson, J Paul, He, Yudong D, Hamadeh, Hisham K, Afshari, Cynthia A, Lightfoot-Dunn, Ruth, Narayanan, Padma Kumar

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Assessing gene significance from cDNA microarray expression data via mixed models von Wolfinger, R D, Gibson, G, Wolfinger, E D, Bennett, L, Hamadeh, H, Bushel, P, Afshari, C, Paules, R S

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