Growth differentiation factor 15 as a potential therapeutic for treating obesity von Hale, Clarence, Véniant, Murielle M.

Volltext

FGF21 acts as a negative regulator of bile acid synthesis von Chen, Michelle M, Hale, Clarence, Stanislaus, Shanaka, Xu, Jing, Véniant, Murielle M

Volltext

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice von Xu, Jing, Lloyd, David J, Hale, Clarence, Stanislaus, Shanaka, Chen, Michelle, Sivits, Glenn, Vonderfecht, Steven, Hecht, Randy, Li, Yue-Sheng, Lindberg, Richard A, Chen, Jin-Long, Jung, Dae Young, Zhang, Zhiyou, Ko, Hwi-Jin, Kim, Jason K, Véniant, Murielle M

Volltext

Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance von Hale, Clarence, Chen, Michelle M, Stanislaus, Shanaka, Chinookoswong, Narumol, Hager, Todd, Wang, Minghan, Véniant, Murielle M, Xu, Jing

Volltext

FGF21 promotes metabolic homeostasis via white adipose and leptin in mice von Véniant, Murielle M, Hale, Clarence, Helmering, Joan, Chen, Michelle M, Stanislaus, Shanaka, Busby, Jim, Vonderfecht, Steven, Xu, Jing, Lloyd, David J

Volltext

The evolving systemic biomarker milieu in obese ZSF1 rat model of human cardiometabolic syndrome: Characterization of the model and cardioprotective effect of GDF15 von Stolina, Marina, Luo, Xin, Dwyer, Denise, Han, Chun-Ya, Chen, Rhonda, Zhang, Ying, Xiong, YuMei, Chen, Yinhong, Yin, Jun, Shkumatov, Artem, Ason, Brandon, Hale, Clarence, Veniant, Murielle M.

Volltext

GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys von Lu, Shu-Chen, Chen, Michelle, Atangan, Larissa, Killion, Elizabeth A., Komorowski, Renee, Cheng, Yuan, Netirojjanakul, Chawita, Falsey, James R., Stolina, Marina, Dwyer, Denise, Hale, Clarence, Stanislaus, Shanaka, Hager, Todd, Thomas, Veena A., Harrold, John M., Lloyd, David J., Véniant, Murielle M.

Volltext

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept von Ashton, Kate S., Andrews, Kristin L., Bryan, Marion C., Chen, Jie, Chen, Kui, Chen, Michelle, Chmait, Samer, Croghan, Michael, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Jordan, Steve R., Kurzeja, Robert J. M., Michelsen, Klaus, Pennington, Lewis D., Poon, Steve F., Sivits, Glenn, Van, Gwyneth, Vonderfecht, Steve L., Wahl, Robert C., Zhang, Jiandong, Lloyd, David J., Hale, Clarence, St. Jean, David J.

Volltext

A volumetric method for quantifying atherosclerosis in mice by using microCT: comparison to en face von Lloyd, David J, Helmering, Joan, Kaufman, Stephen A, Turk, James, Silva, Matt, Vasquez, Sergio, Weinstein, David, Johnston, Brad, Hale, Clarence, Véniant, Murielle M

Volltext

Abstract 15927: Polyunsaturated Fatty Acid Levels and Their Relationship With Peak Exercise Measures in HFpEF von Prasad, Cheshta, Campain, Joseph, Helmering, Joan, Hale, Clarence, Chen, Michelle, Veniant-Ellison, Murielle, Malhotra, Rajeev, Lewis, Gregory

Volltext

Synthesis of novel melanocortin 4 receptor agonists and antagonists containing a succinamide core von Xi, Ning, Hale, Clarence, Kelly, Michael G., Norman, Mark H., Stec, Markian, Xu, Shimin, Baumgartner, James W., Fotsch, Christopher

Volltext

Structure−Activity Relationship of (1-Aryl-2-piperazinylethyl)piperazines:  Antagonists for the AGRP/Melanocortin Receptor Binding von Arasasingham, Premilla N, Fotsch, Christopher, Ouyang, Xiaohu, Norman, Mark H, Kelly, Michael G, Stark, Kevin L, Karbon, Bill, Hale, Clarence, Baumgartner, James W, Zambrano, Martha, Cheetham, Janet, Tamayo, Nuria A

Volltext

Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH2 von FOTSCH, Christopher, SMITH, Duncan M, TAMAYO, Nuria A, NING XI, BAUMGARTNER, James W, ADAMS, Jeffrey A, CHEETHAM, Janet, CROGHAN, Michael, DOHERTY, Elizabeth M, HALE, Clarence, JAROSINSKI, Mark A, KELLY, Michael G, NORMAN, Mark H

Volltext

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors von Lloyd, David J., St Jean, David J., Kurzeja, Robert J. M., Wahl, Robert C., Michelsen, Klaus, Cupples, Rod, Chen, Michelle, Wu, John, Sivits, Glenn, Helmering, Joan, Komorowski, Renée, Ashton, Kate S., Pennington, Lewis D., Fotsch, Christopher, Vazir, Mukta, Chen, Kui, Chmait, Samer, Zhang, Jiandong, Liu, Longbin, Norman, Mark H., Andrews, Kristin L., Bartberger, Michael D., Van, Gwyneth, Galbreath, Elizabeth J., Vonderfecht, Steven L., Wang, Minghan, Jordan, Steven R., Véniant, Murielle M., Hale, Clarence

Volltext

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 3. Structure–Activity Relationships within the Aryl Carbinol Region of the N‑Arylsulfonamid... von Nishimura, Nobuko, Norman, Mark H, Liu, Longbin, Yang, Kevin C, Ashton, Kate S, Bartberger, Michael D, Chmait, Samer, Chen, Jie, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Jordan, Steven R, Kunz, Roxanne K, Pennington, Lewis D, Poon, Steve F, Siegmund, Aaron, Sivits, Glenn, Lloyd, David J, Hale, Clarence, St. Jean, David J

Volltext

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σ... von Pennington, Lewis D, Bartberger, Michael D, Croghan, Michael D, Andrews, Kristin L, Ashton, Kate S, Bourbeau, Matthew P, Chen, Jie, Chmait, Samer, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Hong, Fang-Tsao, Hungate, Randall W, Jordan, Steven R, Kong, Ke, Liu, Longbin, Michelsen, Klaus, Moyer, Carolyn, Nishimura, Nobuko, Norman, Mark H, Reichelt, Andreas, Siegmund, Aaron C, Sivits, Glenn, Tadesse, Seifu, Tegley, Christopher M, Van, Gwyneth, Yang, Kevin C, Yao, Guomin, Zhang, Jiandong, Lloyd, David J, Hale, Clarence, St. Jean, David J

Volltext

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis von Tamayo, Nuria A, Norman, Mark H, Bartberger, Michael D, Hong, Fang-Tsao, Bo, Yunxin, Liu, Longbin, Nishimura, Nobuko, Yang, Kevin C, Tadesse, Seifu, Fotsch, Christopher, Chen, Jie, Chmait, Samer, Cupples, Rod, Hale, Clarence, Jordan, Steven R, Lloyd, David J, Sivits, Glenn, Van, Gwyneth, St. Jean, David J

Volltext

Abstract 128: Recombinant Lecithin Cholesterol Acyltransferase Generates Mature High Density Lipoprotein with Increased Capacity to Efflux Cholesterol via ABCG1 in Cynomolgus Monke... von Peach, Matthew, Chen, Michelle M, Cai, Feng, Peng, Joanna Z, Tang, Chongren, Hale, Clarence, Everds, Nancy, Fitzpatrick, V. D, Shaywitz, Adam J, Zhou, Mingyue, Xu, Ren

Volltext

Discovery of a Potent, Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-iso... von Véniant, Murielle M, Hale, Clarence, Hungate, Randall W, Gahm, Kyung, Emery, Maurice G, Jona, Janan, Joseph, Smriti, Adams, Jeffrey, Hague, Andrew, Moniz, George, Zhang, Jiandong, Bartberger, Michael D, Li, Vivian, Syed, Rashid, Jordan, Steven, Komorowski, Renée, Chen, Michelle M, Cupples, Rod, Kim, Ki Won, St. Jean, David J, Johansson, Lars, Henriksson, Martin A, Williams, Meredith, Vallgårda, Jerk, Fotsch, Christopher, Wang, Minghan

Volltext

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 2. Leveraging Structure-Based Drug Design to Identify Analogues with Improved Pharmacokinet... von St. Jean, David J., Ashton, Kate S., Bartberger, Michael D., Chen, Jie, Chmait, Samer, Cupples, Rod, Galbreath, Elizabeth, Helmering, Joan, Hong, Fang-Tsao, Jordan, Steven R., Liu, Longbin, Kunz, Roxanne K., Michelsen, Klaus, Nishimura, Nobuko, Pennington, Lewis D., Poon, Steve F., Reid, Darren, Sivits, Glenn, Stec, Markian M., Tadesse, Seifu, Tamayo, Nuria, Van, Gwyneth, Yang, Kevin C., Zhang, Jiandong, Norman, Mark H., Fotsch, Christopher, Lloyd, David J., Hale, Clarence

Volltext